DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and CG7333

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_650814.2	Gene:	CG7333 / 42334	FlyBaseID:	FBgn0038715	Length:	541	Species:	Drosophila melanogaster

Alignment Length:	548	Identity:	136/548 - (24%)
Similarity:	232/548 - (42%)	Gaps:	89/548 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 IISQIGDFRRYQLFFFFIVLLCKFGTGWHTLG--HIF---LAAPTP-----------LSCK---- 68
            ::.:.|::.|:|     :::|..:|. .:.||  |.|   |...||           ||.:
  Fly     6 VLDKCGNYGRFQ-----VMILLLYGY-TNILGSLHYFSQTLITFTPEHWCFHADLNGLSVEGIRS 64

  Fly    69 -TENVT-DPCSD---------------ECSETEFDTSVFQSTIITEWNLTCESKQLASLSQSIVM 116
             .||:: ..|:.               :|....|:......:|.||....|:.....::.||...
  Fly    65 VYENISASSCTPLLGVVNGTGVVSTNRKCRNWIFNRESGYESITTELKWVCDKSHHPAVGQSFFF 129

  Fly   117 LGILFGSILFGMFADRYGRRPAFL--TCCFM--QLITGLIVCVSPYYWFYCLFRFLVAVATAGTM 177
            :|.:.|:|:||..:|:.||.|:.|  |.|..  ..||..:..:.   || ...||:..::|....
  Fly   130 MGSVVGTIIFGYLSDQVGRLPSLLMATLCGATGDFITSFVHTLP---WF-AFSRFMSGLSTDTMY 190

  Fly   178 TTSFVLLMEIVGPKKREM-VAILYQIPFNIGHASLALFAYFIREWRWFQFSITIFSIVFVIYIWL 241
            ...::|:.|.:.||.|.. :.|:..:.:..|..:....|.:|..||.:.:..::.::..:||.:|
  Fly   191 YLMYILVFEYLSPKSRTFGLNIILAVFYCFGLMTSPWAAIWIGNWRRYLWLASLPALGVLIYPFL 255

  Fly   242 VPESPRWLFTTGKLDKSIKILEKIAKCNKAPTETIRPEIEAAYGALAARQPVK----KGTVVDLF 302
            :.||.:||.|..|.|.::..|:|:||.|:...|....:....|......|..|    :.|.:.:|
  Fly   256 ICESAQWLLTKRKYDDAVICLKKVAKFNRRHVEESVFDEFVKYYRERELQDYKLNSHEDTFLAMF 320

  Fly   303 RTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAGVGIPGTCLCALMTKYLGRK 367
            .||.:|..|:.:....:::.:......:.:..||.:.|...:..:.|.:|......|:...:|||
  Fly   321 LTPRLRRFTLTLLVKSVIITLSCDVINRNMEGLGTSPFKLFSFTSIVYLPAGVAILLLQNKIGRK 385

  Fly   368 KTLLLSNGCSAL---GLI------LLACLSTQAEAVRVTCAT-IGLFGASITFPNVYLYGGELFP 422
                 ...|:||   |||      ::|.|.....|:.:.... :|.|||::::.....|..|:.|
  Fly   386 -----GMACTALFVGGLITTATGFMIAHLDPTENALLLAIMVGLGRFGATVSYDAEIQYAAEIIP 445

  Fly   423 TVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLGT---IFLPETRGTPL 484
            |.||...|....::|...|.:|..::.||.|   ..||.....|.|...|.   :.||||....|
  Fly   446 TSVRGQAVSNIHVIGLASSSLAFYVIYLAQY---YKPLPSIFISCLMFFGAGLCLTLPETLNKKL 507

  Fly   485 PETLEDGE------------TFGRKKKD 500
            ||||.|||            .|.||:|:
  Fly   508 PETLADGEKFALNESFLYFPCFSRKEKN 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	108/423 (26%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	101/411 (25%)
CG7333	NP_650814.2	2A0119	11..510	CDD:273328	126/516 (24%)
CG7333	NP_650814.2	MFS	126..499	CDD:119392	96/384 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	4	4.010