DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and CG6126

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_650528.1	Gene:	CG6126 / 41967	FlyBaseID:	FBgn0038407	Length:	555	Species:	Drosophila melanogaster

Alignment Length:	536	Identity:	156/536 - (29%)
Similarity:	256/536 - (47%)	Gaps:	61/536 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DPIISQIGDFRRYQLFFFFIVLLCKFGTGWHTLGHIFLAAPTPLSCKTENVT------------- 73
            :.::.::|:|.:||...||:.:|.....|.|.|..:.:||.....|..|.|.
  Fly     8 EDLMGKLGEFGKYQFLQFFLQVLSGLTAGMHMLSLVTVAAVPEHRCFIEGVDNSSLSVTPWNSSA 72

  Fly    74 -------------------DPCSD------ECSETEFDTSVFQSTIITEWNLTCESKQLASLSQS 113
                               ||.|.      .|....:||:.::::...:||..|:.:.:.::.|:
  Fly    73 ILAAIPLKPNGELESCLMFDPSSPGTNTTINCERYVYDTTYYKTSRTIDWNFVCDRRWMGAIVQT 137

  Fly   114 IVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGLIVCVSPYYWFYCLFRFLVA-VATAGTM 177
            :.|||:..|::..|..||:.||:..|......|||.|:.|...|.|:.:.:.|:|:. |.:||..
  Fly   138 VFMLGVFTGAVTLGGLADKVGRKTVFCWSALFQLIIGVGVAFIPEYFSFMVARYLLGIVGSAGAY 202

  Fly   178 TTSFVLLMEIVGPKKREMVAILYQIPFNIGHASLALFAYFIREWRWFQFSITIFSIVFVIYIWLV 242
            ...|||.||:|||.||.:..|.:|..|..|...:|.:...|.:.:|.|....:...:|:.:.|.:
  Fly   203 ICGFVLTMELVGPTKRTVCGITFQAVFAGGIMLVAGWGALIPDRQWLQVIYGLHGCLFLGHWWWL 267

  Fly   243 PESPRWLFTTGKLDKSIKILEKIAKCNKA--PTETIRPEIEAAYGALAARQPVKKGTVVDLFRTP 305
            .||||||:..|:..:::.|:.|..:.|.:  |.:. ...::.|....||.:....| :.||||||
  Fly   268 DESPRWLWMQGRAAEAVDIVAKGLRINGSGIPVDK-EYYVQKAKQQAAAEEKSSAG-LSDLFRTP 330

  Fly   306 YMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAGVGIPGTCLCALMTKYLGRK--- 367
            .:|:||:.:...|....:||||.:.....|.||.::...|...|..|.......:...|||:
  Fly   331 NLRMKTLNVCLCWFANSLVYYGLSLSAGKLYGNPYLILFIMGLVEFPSYITIVFVLDRLGRRSIT 395

  Fly   368 KTLLLSNGCSALGLILLACLSTQAEAVRVTCATIGLFGASITFPNVYLYGGELFPTVVRSSGVGL 432
            .||:|..|...:....:|..||.:.|| |....:.:.|   :|..:|.|..||||||||:|.:||
  Fly   396 STLMLGGGLCCIVAAYIAQGSTTSTAV-VMAGKLLIAG---SFAVIYNYSAELFPTVVRNSAMGL 456

  Fly   433 CSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLGTIFLPETRGTPLPETLEDGETF--- 494
            .||..|:...:.|||..|.::...:..::||:.::::....:|||||...|:||::||||.|
  Fly   457 GSMCARLSGALTPLITLLDSFDPKIPAVLFGVVALISGFWVMFLPETMNQPMPESIEDGENFGKG 521

  Fly   495 --------GRKKKDQA 502
                    ||||:..:
  Fly   522 DTWFSQCAGRKKRQNS 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	127/407 (31%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	120/395 (30%)
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	145/500 (29%)
CG6126	NP_650528.1	MFS	130..501	CDD:119392	116/376 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	225	1.000	Domainoid score	I682
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I1021
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D13331at6656
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm8406
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
	9	9.100