DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8654 and CG6006

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001097812.1	Gene:	CG6006 / 41962	FlyBaseID:	FBgn0063649	Length:	603	Species:	Drosophila melanogaster

Alignment Length:	543	Identity:	134/543 - (24%)
Similarity:	232/543 - (42%)	Gaps:	86/543 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ADRPQDPKAP----KPLKPVTKTGDPIISQIGDFRRYQLFFFFIVLLCKFGTGWHTLGHIFLAAP 62
            |..||.|.|.    .|.....:| |.|...:|.:.::||....::.|.:....:|....|:.||.
  Fly    60 AATPQSPAAAVSGLDPADDEDET-DVIGDLMGHYGKWQLLMTVLLSLFQVPNTFHISSSIYQAAN 123

  Fly    63 TPLSC---------------------------------KTENVTDPCSD------------ECSE 82
            ....|                                 :..|.|...||            .|.:
  Fly   124 KDFWCQRPAQLQHMPVATWRNLSGSVDNCRRWEGIDWSQVSNETTLPSDWKTPAEMDKKLVACEK 188

  Fly    83 TEFDTS-VFQSTIITEWNLTCESKQLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQ 146
            .|::|: ...:|..::|:|.||.:.|.::::...:||:..|.|:.|..:|::||:........:|
  Fly   189 WEYETNDNVGNTWTSQWDLVCEKEHLKNVAEMFFLLGVATGGIISGYLSDKFGRKTMLFISAVLQ 253

  Fly   147 LITGLIVCVSPYYWFYCLFRFLVAVATAGTMTTSFVLLMEIVGPKKREMVAILYQIPFNIGHASL 211
            .|.||.:.:...:..|...|.|:.:.:.....:..:|.:|.|..|.|.:..:....|..|.:..:
  Fly   254 TIFGLWLYICSSFELYLTLRALLGLVSVSVTYSGLILAIEYVDGKWRTIAGMYNLFPLPISYMII 318

  Fly   212 ALFAYFIREWRWFQFSITIFSIVFVIYIW-LVPESPRWLFTTGKLDKSIKILEKIAKCNKAPTET 275
            :..||..::::..|..|.|..| |:.::| :||||||||...|::|:..:|:|..||.|..
  Fly   319 SGLAYLTQDYQRLQLCIGIPGI-FLCFLWFVVPESPRWLLVKGRIDEVRRIIEAAAKFNGR---- 378

  Fly   276 IRPEIEAAYGALAARQPVKKGTVVDLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIF 340
               ::.|.|......|......|..|||:.|:|..:|.....|..:.:||||....:|:.|||::
  Fly   379 ---QLPADYQLTPPTQESSTQDVTYLFRSSYLRRISICFFCIWFTMNLVYYGIILNMSSFGGNVY 440

  Fly   341 ISNAIAAGVGIPGTCLCALMTKYLGRKKTLLLSNGCSALGLILLACLSTQAEA--VRVTCATIGL 403
            :::|:|..|.||...:...:...:|:|.....:..|:.:.....|.....|:.  :::|...:|.
  Fly   441 LNSALAGLVEIPAIAVAMYIITKVGKKWLFCATLICAGVACCCAAITEGHADLLWLKITFLMMGK 505

  Fly   404 FGASITFPNVYLYGGELFPTVVRSSGVGLCSMVGRIGSIVAP------------LIVDLAAYGLW 456
            |..|.....:.:|..||:||.:|:.|||.|::...:..|:.|            |:..|.|:.
  Fly   506 FTISAGNTIMPVYTAELYPTPIRNVGVGACNVAAGLALILTPYLSLLNKIEGHLLMTLLTAWS-- 568

  Fly   457 VAPLIFGIFSILAMLGTIFLPET 479
                |||.|.:|      |||||
  Fly   569 ----IFGGFVVL------FLPET 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	110/411 (27%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	106/405 (26%)
CG6006	NP_001097812.1	2A0119	90..581	CDD:273328	123/510 (24%)
CG6006	NP_001097812.1	MFS	222..579	CDD:119392	99/376 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D13331at6656
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	7	7.070