DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and CG14856

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_650391.1	Gene:	CG14856 / 41790	FlyBaseID:	FBgn0038261	Length:	557	Species:	Drosophila melanogaster

Alignment Length:	551	Identity:	131/551 - (23%)
Similarity:	222/551 - (40%)	Gaps:	88/551 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DPIISQIGDFRRYQLFFFFIVLLCKFGTGWH-----TLGHI-----------------FLAAPTP 64
            |.|:.:.||..|||.....:..|..|....|     .:|.:                 ..|...|
  Fly     6 DEILVKCGDSHRYQYMLLALYGLLMFIVSRHYFAQNVIGFVPDHWCYHEQLENRSYAEIAAIYAP 70

  Fly    65 L---SCKT--------ENVTDPCSDECSE--TEFDTSVFQSTIITEWNLTCESKQLASLSQSIVM 116
            .   ||..        .|.| ..|:.|:.  ..:|...........|  .|:....|.:.||:..
  Fly    71 FKRPSCTRLASINMDGSNAT-ASSEPCNRWIYHYDHGFISMNADLNW--VCDDAYKARVGQSLFF 132

  Fly   117 LGILFGSILFGMFADRYGRRPAFL--TCC-FM---------QLITGLIVCVSPYYWFYCLFRFLV 169
            :|.:.|::|||:..||.||..|.:  .|| |:         .|:|            :...||:.
  Fly   133 VGSMCGTLLFGLLGDRIGRIKAVVLANCCGFLGDSATIFAETLLT------------FSASRFVS 185

  Fly   170 AVATAGTMTTSFVLLMEIVGPKKREM-VAILYQIPFNIGHASLALFAYFIREWRWFQFSITIFSI 233
            .:|........|:|::|.|.|..|.: :.:...:.:.:|....:....::..||.|.....:..:
  Fly   186 GLAAEANSYLMFILVLEYVSPTMRSVGLNLTMCVFYGLGMICASWQGVWLGSWRSFMVWTALPQL 250

  Fly   234 VFVIYIWLVPESPRWLFTTGKLDKSIKILEKIAKCNK-----APTETIRPEIEAAYGALAARQPV 293
            :...:.:|:.||.:||.|....|.:...|.::||.|:     |..|..|...:.......::..:
  Fly   251 LVTGFYFLIQESAQWLVTRQDFDGAELRLRRVAKFNRRDVSEADYELFRQHCKTKESEARSQMSM 315

  Fly   294 -KKGTVVDLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAGVGIPGTCLC 357
             |:..::|.|:.|.:|::.|::...:.:|.:.|...::.|..|..:.|:..::.|....|.....
  Fly   316 QKQARLIDSFKLPRLRLRLIYVTVVFSIVTLCYNTMSRNVEGLSISPFVMFSLFALTLPPSGIFQ 380

  Fly   358 ALMTKYLGRKKTLLLSNGCSALGL------ILLACLSTQAEAVRVTCATIGLFGASITFPNVYLY 416
            ..:.|:.|||.|.::|  .:|.||      ||||..:..:..|.|....:..||.|:|..:....
  Fly   381 TQVQKHFGRKFTSVVS--MTATGLMTATTGILLAFWTQHSATVMVCLLLMCRFGISVTTGSTMQI 443

  Fly   417 GGELFPTVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLGTIFLPETRG 481
            ..||.||.|||||:.:..:.....|.::|.|:.|..|....:.:|..|..:::....:.|.|||.
  Fly   444 STELMPTCVRSSGLAVIHVTAAALSFISPFILHLDTYFRAASSIITCILLLVSAWICLLLSETRN 508

  Fly   482 TPLPETLEDGETFGR-----------KKKDQ 501
            ..||.||.:||.||:           ||.||
  Fly   509 KKLPLTLAEGEEFGKGERMFDFMRSFKKADQ 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	102/426 (24%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	95/414 (23%)
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	119/517 (23%)
CG14856	NP_650391.1	MFS	129..503	CDD:119392	91/387 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	3	3.010