DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and CG14855

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_650390.2	Gene:	CG14855 / 41789	FlyBaseID:	FBgn0038260	Length:	556	Species:	Drosophila melanogaster

Alignment Length:	542	Identity:	125/542 - (23%)
Similarity:	215/542 - (39%)	Gaps:	94/542 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DPIISQIGDFRRYQLFFFFIVLLCKFG-------------------------------TGWHTLG 55
            :.|:::.|:..|||     .|||..:|                               ..:..:.
  Fly     4 EEILAKCGNSSRYQ-----FVLLALYGYLMVVVSMHYFSQNVISFVPDHWCYHEQLENRSFAEIE 63

  Fly    56 HIFLAAPTPLSCKTENVTDP------CSDECSETEFDTSVFQSTIITEWNLTCESKQLASLSQSI 114
            .|:.....|...:.|.:.:.      ..:.|:...:.......::.||.|..|:....|.:.||:
  Fly    64 KIYSQFEKPSCTRLEKIDEDGQNHTLSRERCNRWIYKYDFGYKSMNTELNWVCDEAYKARVGQSL 128

  Fly   115 VMLGILFGSILFGMFADRYGRRPAFLTC--C-----FMQLITGLIVCVSPYYWFYCLFRFLVAVA 172
            ..:|.:.|::.||:..||.||..|.:..  |     |..:..|.:...|       :.||:..:|
  Fly   129 FFVGSVCGTLAFGLLGDRIGRIRALILANWCGFLGDFSTIFAGSLTSFS-------ISRFISGLA 186

  Fly   173 TAGTMTTSFVLLMEIVGPKKRE--MVAILYQIPFNIGHASLALFAYFIREWRWFQFSITIFSIVF 235
            ........::|::|.|.|..|.  :..:|... :.:|.......|.::..||.|....::..::.
  Fly   187 ADANSYLMYILILEYVSPSLRNVGLNTVLGSF-YCLGLIGACWLAVWVGHWRIFLACSSVPLLLV 250

  Fly   236 VIYIWLVPESPRWLFTTGKLDKSIKILEKIAKCNKAPT-----ETIRPEIEAAYGALAARQPVKK 295
            .::.:||.||.:||.|...:|.:|:.||::||.|:...     :..|...|..|  ...:...:.
  Fly   251 TLFYFLVQESAQWLVTRNDVDGAIRRLERVAKINRRQVADKDFKDFRIYCEQHY--RKDKNQEEH 313

  Fly   296 GTVVDLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAGVGIPGTCLCALM 360
            ..::|:.:||.||.....:...::::...|...|:.|..||.:.||..::.|....|...|..|:
  Fly   314 AKLLDMLKTPRMRSTAFKLLLIFIIIVPCYNTIARNVEGLGISPFIMFSLNALTLPPSGYLQGLL 378

  Fly   361 TKYLGRKKT----------------LLLSNGCSALGLILLACLSTQAEAVRVTCATIGLFGASIT 409
            ...:|||.|                |::|.| |...::||..|:..|.           ||.||.
  Fly   379 QDRMGRKATAVGWMAITGIFAVAAGLVISQG-SNRNVLLLVGLTMAAR-----------FGVSIA 431

  Fly   410 FPNVYLYGGELFPTVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLGTI 474
            ......:..||.||.||..||.:..:.|...|.::|.|:.|..|......:|.|:..:......:
  Fly   432 DGASSQFSTELIPTSVRGRGVAVVHVAGFAASFLSPYILHLGTYYKPAPSIILGLLFLSGAYVCL 496

  Fly   475 FLPETRGTPLPETLEDGETFGR 496
            .|||||...||.:|.:||.|||
  Fly   497 LLPETRNKKLPMSLAEGEEFGR 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	106/431 (25%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	99/419 (24%)
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	116/522 (22%)
CG14855	NP_650390.2	MFS	127..499	CDD:119392	93/393 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	5	5.060