DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and slc22a6l

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_996960.2	Gene:	slc22a6l / 404609	ZFINID:	ZDB-GENE-040426-2249	Length:	560	Species:	Danio rerio

Alignment Length:	526	Identity:	153/526 - (29%)
Similarity:	248/526 - (47%)	Gaps:	64/526 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 IISQIGDFRRYQLFFFFIVLLCKFGTGWHTLGHIFLAAPTPLSCKTE------------------ 70
            ::.|:|...|:|:....::.:.......|.|...|:||..|..|:..
Zfish     6 LLEQVGSTGRFQVLHVTLLSMPILMMASHNLLQNFVAAVPPHHCQPHANLSMSSTDAMDVLRATV 70

  Fly    71 ------------------------NVTDPCSDE-CSETE---------FDTSVFQSTIITEWNLT 101
                                    |.::...|| .:|||         ::.:...|||||||:|.
Zfish    71 PLGLNGKLERCKRYTTPQWQILSLNTSESLWDESMAETETQSCEDGWFYNMTEMSSTIITEWDLV 135

  Fly   102 CESKQLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGLIVCVSPYYWFYCLFR 166
            |:.:.|..:||:..|.|:|.|:|:||..:||:|||...|....|..|.|..|..|..:..:|:||
Zfish   136 CDYRALKQMSQTTYMGGVLVGAIVFGGLSDRFGRRVLLLISNLMMAIGGTCVAFSTSFTMFCVFR 200

  Fly   167 FLVAVATAGTMTTSFVLLMEIVGPKKREMVAILYQIPFNIGHASLALFAYFIREWRWFQFSITIF 231
            ....:|.:|.:..||.|::|.:..:.|.:|.......:..|...||..||.||:|||...::::.
Zfish   201 VCCGMALSGLVLNSFSLIVEWIPTRVRTVVGTGTGYCYTTGQLILAAVAYCIRDWRWLTLAVSLP 265

  Fly   232 SIVFVIYIWLVPESPRWLFTTGKLDKSIKILEKIAKCNKAPTETIRPEIEAAYGALAARQPVKKG 296
            ..|..:|.|...||.|||..|.|.::::|.|:.:|:.|....|..:.::|....::.......||
Zfish   266 FYVSFLYSWWFLESARWLVLTKKPEQAVKNLKTVARINGRSAEGDKIDLEMLQESMKKEMACSKG 330

  Fly   297 --TVVDLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAGVGIPGTCLCAL 359
              :.:||.||..||..||.::..|......|||.:..:...|.:|::...|...|.||...:..:
Zfish   331 SYSALDLLRTSTMRTITICLSAVWFSTSFAYYGLSMDLQKFGVSIYLIQIIFGAVDIPAKIIVTI 395

  Fly   360 MTKYLGRKKTLLLSNGCSAL---GLILLACL--STQAEAVRVTCATIGLFGASITFPNVYLYGGE 419
            ....|||:     .:.|.||   |:::|..|  .:..:.:|.:.|.||....:.:|...|||.||
Zfish   396 CMSMLGRR-----PSQCGALVLAGIMILINLLVPSDLQMLRTSLAVIGKGCLAASFNCCYLYAGE 455

  Fly   420 LFPTVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLGTIFLPETRGTPL 484
            |:|||:|.||:|..||:.|.|::|||:::.|.....|:...|:|...|::.:...|||||...||
Zfish   456 LYPTVIRQSGMGWVSMMARFGAMVAPMVLLLGDDYPWIPGFIYGGAPIVSGIFAFFLPETLSQPL 520

  Fly   485 PETLED 490
            |:|::|
Zfish   521 PDTIQD 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	134/408 (33%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	127/396 (32%)
slc22a6l	NP_996960.2	2A0119	11..523	CDD:273328	150/516 (29%)
slc22a6l	NP_996960.2	MFS	116..513	CDD:119392	127/401 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.050