DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and CG7458

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_649374.1	Gene:	CG7458 / 40441	FlyBaseID:	FBgn0037144	Length:	572	Species:	Drosophila melanogaster

Alignment Length:	543	Identity:	145/543 - (26%)
Similarity:	246/543 - (45%)	Gaps:	80/543 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DPIISQIGDFRRYQLFFFFIVLLC--KFGTGWHTLGHIFLAAPTPLSCKTENVTDPCS------- 77
            |.|:.:||.|.|||:..:  ||||  .....:.::.::|.|:.....|.......|.|
  Fly    39 DAILVRIGQFGRYQIINY--VLLCVPMLFNAFFSISYVFTASTVVHRCTVPQCDSPSSVYEEDWL 101

  Fly    78 -----------DEC------------------------------SET---EFDTSVFQSTIITEW 98
                       |:|                              |||   :|.....:.||.||:
  Fly   102 GFTIPKKNSAWDDCHRYAANISDAISGYTDPSGQYCLKEYFTITSETCGRDFKFRDEEKTISTEF 166

  Fly    99 NLTCESKQLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGLIVCVSPYYWFYC 163
            .:.||.:...|:..:|..:|...|..|.|.||||||||........:..:.|:|..:|..|..:.
  Fly   167 GIYCEDEWKLSMVGTINNVGQFVGIPLGGYFADRYGRRTMLAVAGSVSALMGVIRSLSSNYSMFL 231

  Fly   164 LFRFLVAVATAGTMTTSFVLLMEIVGPKKREMVAILYQIPFNIGHASLALFAYFIREWRWFQFSI 228
            :|.||.....:....|:|:|.:|:||||:|...|.:..|.:.:|.|.|...|..::.|||....:
  Fly   232 VFEFLDMAVGSTLFPTAFLLAIELVGPKRRVAAATIITIFYALGEAFLGFLASQVQHWRWLLRVL 296

  Fly   229 TIFSIVFVIYIWLVPESPRWLFTTGKLDKSIKILEKIAKCNKAPTETIRPEIEAAYGALAARQPV 293
            ...:::.::::|::|||.|||.:.|..:|:..:|.:.|:.|:.|.    ||.:......:.||.:
  Fly   297 YAPAVLQILFLWILPESVRWLLSQGAEEKASNVLRRAARINQRPL----PEEQLNDLLTSNRQKL 357

  Fly   294 KKGTVVDLFRTPYMRIKTIF---MAN---NWLVVCMVYYGTAQYVSALGGNIFISNAIAAGVGIP 352
            .:   .:..:.|.||....|   :||   .|....::..|.:.....||||.:.:..:...:.||
  Fly   358 SQ---ANESQYPIMRAVVFFSLRIANCCLCWFTHTLIALGLSLNSVNLGGNKYTNFMLNGFIQIP 419

  Fly   353 GTCLCALMTKYLGRKKTLLLSNGCSALGLILLACLSTQAE------AVRVTCATIGLFGASITFP 411
            |..|..::...:||:.:|     |::: |:...|:...|.      |..:....||....:.:|.
  Fly   420 GLLLPLVIMDRVGRRHSL-----CASM-LLCAICMGASAAVPADNYAGSLALFLIGKLAITCSFQ 478

  Fly   412 NVYLYGGELFPTVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLGTIFL 476
            .:|.:..|:|||.||::.:.||||||||||::||....||.|.::...::|..|::::...|:..
  Fly   479 ILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQTPLLAKYYIYAPQILFATFALISGFLTLAF 543

  Fly   477 PETRGTPLPETLEDGETFGRKKK 499
            |||....||.|:|:.....:.|:
  Fly   544 PETADKVLPTTIEEARDLNQAKR 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	120/413 (29%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	114/401 (28%)
CG7458	NP_649374.1	2A0119	46..554	CDD:273328	139/522 (27%)
CG7458	NP_649374.1	MFS	161..544	CDD:119392	114/395 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.070