DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and SLC22A

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster

Alignment Length:	563	Identity:	153/563 - (27%)
Similarity:	258/563 - (45%)	Gaps:	80/563 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PQDPK---APKPLKPVTKTGDPIISQIGDFRRYQLFFFFIVLLCKFGTGWHTLGHIFLAAPTPLS 66
            |.||.   ||........|.|.|:..:|.|.|:||..|.::.|........::.::|.||.....
  Fly     8 PADPAVEVAPPAKDSEDVTLDAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHR 72

  Fly    67 CKTE-------NVTDP---------------------------------CS--------DECSET 83
            |..|       |..:|                                 ||        :.|:..
  Fly    73 CSVEECDLPGSNYYEPHTNWSIPKNGKDLDSCNRYTNSELPQWNHSVDICSADHFTKNKEACAHN 137

  Fly    84 EFDTSVFQS---TIITEWNLTCESKQLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFM 145
            ||   ||:.   ||..::.:.|:.:...|:..:|..||..||..:.|..||||||..:......:
  Fly   138 EF---VFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGIL 199

  Fly   146 QLITGLIVCVSPYYWFYCLFRFLVAVATAGTMTTSFVLLMEIVGPKKREMVAILYQIPFNIGHAS 210
            ..:.|:|...||.|.::.:|.||..:.::...:|.||:.:|:||||:|.:...:..:.:.:|...
  Fly   200 GAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVL 264

  Fly   211 LALFAYFIREWRWFQFSITIF-SIVFVIYIWLVPESPRWLFTTGKLDKSIKILEKIAKCNKAPTE 274
            ||:.|....:|| ....||.. |::.:.|.|::|||.|||.:.||.:::..||.:.|..||...
  Fly   265 LAMSAKAFHDWR-ILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKREL- 327

  Fly   275 TIRPEIEAAYGALAARQPVKKGT-----VVDLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSA 334
               ||.......||.|..:::.:     :.:.|:....||....:.  |:|..:||||.:..|..
  Fly   328 ---PESVLDKLVLANRDKLQQSSESRFPIREAFKNFKWRIANCSLC--WIVHVLVYYGLSLNVVL 387

  Fly   335 LGGNIFISNAIAAGVGIPGTCLCALMTKYLGRKKT---LLLSNGCSALGLILLACLSTQAE--AV 394
            |.|:.:.:.|..|.|.|||..:..|:....||:.:   |:|::|...:|.|.     |.|:  .:
  Fly   388 LDGDKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIF-----TGADQPVL 447

  Fly   395 RVTCATIGLFGASITFPNVYLYGGELFPTVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVAP 459
            ::....:|....:.:|..:|.:..|::||.:|:|.:..|||:||.||::||....||.|......
  Fly   448 QLVLFLVGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPA 512

  Fly   460 LIFGIFSILAMLGTIFLPETRGTPLPETLEDGETFGRKKKDQA 502
            ::|...:|::.|.|:|.|||....||.|:::.:..|.||:.::
  Fly   513 MLFAGAAIVSGLLTLFFPETTNVVLPTTVQEADAIGVKKQSKS 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	123/415 (30%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	117/403 (29%)
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	141/519 (27%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	115/395 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.070