DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and slc22a4

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_957143.1	Gene:	slc22a4 / 393822	ZFINID:	ZDB-GENE-040426-1517	Length:	553	Species:	Danio rerio

Alignment Length:	531	Identity:	154/531 - (29%)
Similarity:	249/531 - (46%)	Gaps:	78/531 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DPIISQIGDFRRYQLFFFFIVLLCKFGTGWHTLGHIFL-----------------------AAPT 63
            |.|.|.:|.:..:||..|..:.:.....|:..|..:|:                       |.||
Zfish     5 DDITSFLGTWGPFQLTVFLALAISILPNGFVGLYIVFVGDTPAHECLIPEQINISSVWRDAAIPT 69

  Fly    64 PL--------SCK---------------TENV--------TDPCSDECSETEFDTSVFQSTIITE 97
            .:        ||.               |.||        |:||.|..|   :....:||||:||
Zfish    70 QMQDGVLKRSSCSRYRLDTLRQLSMLNYTPNVEVNLSQIETEPCVDGWS---YSQEFYQSTIVTE 131

  Fly    98 WNLTCESKQLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGLIVCVSPYYWFY 162
            |:|.||.:....|:.||...|:|.|:.|.|..:|||||||...|...:|.||.||...||.:..:
Zfish   132 WDLVCEREYKGPLTSSIYFCGVLVGTFLSGQMSDRYGRRPVLFTMMALQTITILIQMFSPSWEVF 196

  Fly   163 CLFRFLVAVATAGTMTTSFVLLMEIVGPKKREMVAIL-YQIPFNIGHASLALFAYFIREWRWFQF 226
            ....|.|..:.......::||..||:.|..|.:...| ..:...||.....|.|||||.|||...
Zfish   197 SAIYFFVGFSGFSNYVVAYVLGSEILSPASRVLFGSLGVFMGSGIGQMFFPLAAYFIRSWRWLVL 261

  Fly   227 SITIFSIVFVIYIWLVPESPRWLFTTGKLDKSIKILEKIAKCNK--APTETI--RPEIEAAYGAL 287
            :..:..:::....|.:|||||||.:.|:..::..:|.:.|:.|:  || |.|  ..|||.
Zfish   262 TNALTGLLYFPLWWFIPESPRWLLSQGRTAEAEAVLRRAAEKNRVTAP-EVIFSSSEIEE----- 320

  Fly   288 AARQPVKKGTVVDLFRTPYMRIKTIFMAN-NWLVVCMVYYGTAQYVSALGGNIFISNAIAAGVGI 351
            ||::.::|.:::|:. :....:.||.:.: .|:|:.|.||......:.|.||.:::..::|.|.:
Zfish   321 AAKKRIQKHSILDIL-SNCNAVSTILICSLLWMVITMSYYALILNTTNLHGNPYLNFFLSAVVEV 384

  Fly   352 PGTCLCALMTKYLGRK----KTLLLSNGCSALGLILLACLSTQAEAVRVTCATIGLFGASITFPN 412
            |...:.||:.::..|:    .||||....    :.::..:.|:.:.:......:|....:..|..
Zfish   385 PAYIIAALLLRFCSRRICQASTLLLGGAL----IFIIQLIPTELQGLATALEMLGKLCVTAAFCV 445

  Fly   413 VYLYGGELFPTVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLGTIFLP 477
            ||....||||||||:..:|.|||..|||||::|.|:.|..|..::..::.|..::.:.:.::.||
Zfish   446 VYAVTSELFPTVVRNMAMGSCSMTARIGSIISPFIIYLGNYYRYIPYIVIGGLALFSGVMSLLLP 510

  Fly   478 ETRGTPLPETL 488
            |::|..||||:
Zfish   511 ESKGKVLPETI 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	129/411 (31%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	123/399 (31%)
slc22a4	NP_957143.1	2A0119	12..520	CDD:273328	149/521 (29%)
slc22a4	NP_957143.1	MFS	144..510	CDD:119392	113/376 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.040