DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and SLC22A25

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	XP_016873173.1	Gene:	SLC22A25 / 387601	HGNCID:	32935	Length:	577	Species:	Homo sapiens

Alignment Length:	469	Identity:	122/469 - (26%)
Similarity:	215/469 - (45%)	Gaps:	55/469 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 TENVTDPCSDECSETEFDTSVFQSTIITEWNLTCESKQLASLSQSIVMLGILFGSILFGMFADR- 132
            :|..|:||.|   ...:|.|.|.|||:|:|:|.|||:.|.|:::.:.|.|::.|..|:|..:||
Human   109 SEPDTEPCVD---GWVYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRK 170

  Fly   133 -----------------------------YGRRPAFLTCCFMQL-ITGLIVCVSPYYWFYCLFRF 167
                                         :||: ..|...::|| |.|.....:|....||..||
Human   171 PLSSPNHVSTDCDEGLEVPIAIHQHHVFWFGRK-FVLRWSYLQLAIVGTCAAFAPTILVYCSLRF 234

  Fly   168 LVAVATAGTMTTSFVLLMEIVGPKKREMVAILYQIPFNIGHASLALFAYFIREWRWFQFSITIFS 232
            |...||...:..:.:|::|.:..:...|...|.....:|||.:|...|:.||:....|..::...
Human   235 LAGAATFSIIVNTVLLIVEWITHQFCAMALTLTLCAASIGHITLGSLAFVIRDQCILQLVMSAPC 299

  Fly   233 IVFVIYIWLVPESPRWLFTTGKLDKSIKILEKIAKCN-----------KAPTETIRPEIEAAYGA 286
            .||.::...:.||.|||....|.::.:|.|.|.|..|           :....|::.|:|||.
Human   300 FVFFLFSRWLAESARWLIINNKPEEGLKELRKAAHRNGMKNAEDILTMEVLKSTMKQELEAAQ-- 362

  Fly   287 LAARQPVKKGTVVDLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAGVGI 351
                   ||.::.:|.|.|.:..:..|::.......:.::|...::..||.|:|:...:...|.:
Human   363 -------KKHSLCELLRIPNICKRICFLSFVRFASTIPFWGLTLHLQHLGNNVFLLQTLFGAVTL 420

  Fly   352 PGTCLCALMTKYLGRKKTLLLSNGCSALGLILLACLSTQAEAVRVTCATIGLFGASITFPNVYLY 416
            ...|:......::.|:.:.:|.....|..|:.:..:..:.:.:||..||:|:..||:........
Human   421 LANCVAPWALNHMSRRLSQMLLMFLLATCLLAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQ 485

  Fly   417 GGELFPTVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLGTIFLPETRG 481
            ..||.|:::|....|:......||..:|.|::.|:.|...:..:|:|:|:||:.|..:.|||||.
Human   486 ENELIPSIIRGRATGITGNFANIGGALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRN 550

  Fly   482 TPLPETLEDGETFG 495
            .||.::::|.|..|
Human   551 QPLLDSIQDVENEG 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	114/443 (26%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	106/431 (25%)
SLC22A25	XP_016873173.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D464838at2759
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.020