DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and CG42269

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	161/546 - (29%)
Similarity:	252/546 - (46%)	Gaps:	84/546 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 PVTKTGDPIISQIGDFRRYQLFFFFIVLLCKFGTGWHTLGHIFLA-------------------A 61
            |.:...|.|:..||:|.|||...|..::...|...:.....|||.                   |
  Fly    67 PPSMDFDDILPLIGEFGRYQKLLFICMIPFSFFVAFVYFSQIFLTLIPEQHWCHVPELDGLDVEA 131

  Fly    62 PTPLSCKTEN----------------------VTDP------CSDECSETEFDTSVFQSTIITEW 98
            ...||....|                      :.||      |....|..  .|.:..:|:.||.
  Fly   132 RLALSIPMTNGEYNNCYMYDVNYTDILAQGKVMADPKWPQVKCRHGWSYN--FTEIPYATVATEQ 194

  Fly    99 NLTCESKQLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGLIVCVSPYYWFYC 163
            |..|:...|.:.:|||..||.:.|.:|||..|||:||.||.:....|.|:.|:.......:|.:.
  Fly   195 NWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTNMMGLLAGVGTAFVSNFWEFA 259

  Fly   164 LFRFLVAVATAGTMTTSFVLLMEIVGPKKREMVAILYQIPFNIGHAS-LALFAYFIREWRWFQFS 227
            :.||.|..|.....|..::|::|.||||.|..||.:....|..|.|. |...|||:.:|:....
  Fly   260 IMRFFVGFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAIFFTGAACLLPWIAYFLADWKLLAI- 323

  Fly   228 ITIFSIVFVIYI-WLVPESPRWLFTTGKLDKSIKILEKIAKCN--KAPTETIR---------PEI 280
            :|...::..|:. ::||||.|||.:.||:||::.||:|:.|.|  :.|.:|.:         .|.
  Fly   324 VTSAPLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQVPPQTYQIFTDSCKRMQEQ 388

  Fly   281 EAAYGALAARQPVKKGTVVDLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAI 345
            ||..|         |.:|:|||::|.:|..|:.:...|:.:.:|:.|..:.|.:||.:||.:..:
  Fly   389 EAQNG---------KYSVLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVRNVGSLGLDIFFTFTL 444

  Fly   346 AAGVGIPGTCLCALMTKYLGRK----KTLLLSNGCSALGLILLACLSTQAEAVRVTCATIGLFGA 406
            |....:|...|..::....||:    .:::||...|.|..::...:.:.|.|:      :|.|..
  Fly   445 ACFTELPADTLLTVILDRFGRRWLACSSMVLSGVFSLLATVVPVGIYSAALAI------MGRFFV 503

  Fly   407 SITFPNVYL-YGGELFPTVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSILAM 470
            :|:: |:.| :..|:.|||||:..|....::|.:.||:||.:|.||.....:..:|.||..|:..
  Fly   504 NISY-NIGLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVYLANISQALPLIILGILGIIGG 567

  Fly   471 LGTIFLPETRGTPLPETLEDGETFGR 496
            |..:.||||....||:||.|||.|||
  Fly   568 LLALLLPETLNHVLPQTLSDGEEFGR 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	131/419 (31%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	125/407 (31%)
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	138/490 (28%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	110/355 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	1	0.900	-	-		E33208_3B9N9
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	7	6.960