DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and CG10486

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster

Alignment Length:	542	Identity:	156/542 - (28%)
Similarity:	249/542 - (45%)	Gaps:	78/542 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DPIISQIGDFRRYQL-FFFFIVLLCKFGTGWHTLGHIFLAAPTP-------------------LS 66
            |.::..||.|.|:|: .|.|::..| |.|.:..||.||:....|                   ||
  Fly    97 DDLLPMIGQFGRFQIRLFLFMIPFC-FITAFVYLGQIFMCLTPPKYYCYVPELLHTPVELRKELS 160

  Fly    67 -----------CKTENV--------------------TDPCSDECSETEFDTSVFQSTIITEWNL 100
                       |:..|.                    |.||. :....|.:...|:|..: |:..
  Fly   161 IPKEKDGSYSRCRMYNTNYTKIHFAENPSAYINTSLPTIPCK-KGYVFEQEGRAFESATM-EFGW 223

  Fly   101 TCESKQLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGLIVCVSPYYWFYCLF 165
            .|:..:.|:.:|.|..||.:.|.:.:|.|||..||..|.::.||:.|:..|...:|..::.:.:.
  Fly   224 LCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALVGSLATSMSTDFFTFAIS 288

  Fly   166 RFLVAVATAGTMTTSFVLLMEIVGPKKREMVA----ILYQIPFNIGHASLALFAYFIREWRWFQF 226
            ||||..:.....|..::|::|.||||.|.:||    .|:..||.:....:||.|   ..||.|.
  Fly   289 RFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLSLALFYSPFTMVMPWIALSA---GNWRRFS- 349

  Fly   227 SITIFSIVFVIYIW-LVPESPRWLFTTGKLDKSIKILEKIAKCNKAPTETIRPEIEAAYGALAAR 290
            |.|...||..::.: |:|||.|||.:.|::||:::||:.:.:.||   :.:..||...:.| :..
  Fly   350 SFTSLPIVLAMFSFCLLPESARWLVSVGEIDKALEILKNVIEVNK---KQVSKEILDLFEA-SCT 410

  Fly   291 QPVKKG------TVVDLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGG-NIFISNAIAAG 348
            |..|:.      ||:.:|:...|....|.|...|:.:.:||.|..:..|.|.. |||:...||..
  Fly   411 QFYKEELDGRDFTVLSIFKRKRMARYMILMILIWMSISLVYDGHVRAASVLDSENIFLFFTIACA 475

  Fly   349 VGIPGTCLCALMTKYLGRKKTLLLSNGCSALGLILLACLSTQAEAVRVTCATIGLFGASITFPNV 413
            ..:||..|..|.....||:.........|.:..:|.|....:|. :|:: |..|.|.::|.: |:
  Fly   476 TELPGNILVILTLDRAGRRWCSFFYTSLSGVFSLLGASFQNRAN-MRMS-ALAGRFFSNICY-NI 537

  Fly   414 YL-YGGELFPTVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLGTIFLP 477
            .| :..|:.|||||:.||.....:|.:..:::|.:|.|:...|....::.|...|...|..:|||
  Fly   538 GLQWAAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVYLSKKSLSSTLIVLGALGIFGGLLALFLP 602

  Fly   478 ETRGTPLPETLEDGETFGRKKK 499
            ||....|||||.||..||:.::
  Fly   603 ETLNHELPETLSDGAQFGKNQR 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	125/414 (30%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	119/402 (30%)
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	147/521 (28%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	115/381 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	1	0.900	-	-		E33208_3B9N9
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	7	6.960