DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and Slc22a14

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001032838.1	Gene:	Slc22a14 / 382113	MGIID:	2685974	Length:	629	Species:	Mus musculus

Alignment Length:	524	Identity:	124/524 - (23%)
Similarity:	219/524 - (41%)	Gaps:	79/524 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 IISQIGDFRRYQ----LFFFFIVLLCKFGTGWHTLGHIFLAAPTPLSCKTE-------------- 70
            ::..||:|..:|    :..|...:|..|....|   |..|.|..|. |.|.
Mouse    54 VMDAIGEFGTFQWRLVVLTFIPSILSTFFIFSH---HFLLTAQRPY-CNTSWILEVGPNLTEDEQ 114

  Fly    71 -NVTDPCSDECS----------ETEFDTSV-----------------FQST--IITEWNLTCESK 105
             |:|.|.:...|          ..:.|:.:                 |..|  :|.|::|.|.::
Mouse   115 LNLTLPRAPNGSFLTCLMYIPVPWDLDSIIHFGLNYTETCKFGWIYPFAHTRSLINEFDLVCGNE 179

  Fly   106 QLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGLIVCVSPYYWFYCLFRFLVA 170
            .......::.:.|:|.||:|||..:|:.||.|..|......||.|........::.|..|||.||
Mouse   180 PNKENGLTVFLSGVLTGSLLFGFLSDKLGRYPIILLSLLGFLIFGFGTAFVSSFYQYLFFRFFVA 244

  Fly   171 VATAGTMTTSFVLLMEIVGPKKREMVAILYQIPFNIGHASLALFAYFIREWRWFQF--SITIFSI 233
            .|:.|....|..|:||.:..:.|....||......||...|...||.:..||....  .:.:|.:
Mouse   245 QASVGYAICSVSLVMEWLVGEHRAQAVILQHSFLTIGVILLTGLAYKVVHWRLLCLLGGMPMFPL 309

  Fly   234 VFVIYIWLVPESPRWLFTTGKLDKSIKILEKIAKCNK--APTETIRPEIEAAYGALAARQPVKKG 296
              :..||::.||||||...||::::.|:|...|:.||  .|...:. |::      .:.:.|.|.
Mouse   310 --ICNIWVLRESPRWLMVRGKVEEAKKVLCYAAEVNKKTIPLNLLN-ELQ------ISGKKVAKA 365

  Fly   297 TVVDLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAGVGIPGTCLCALMT 361
            :::|.....::....:.:...|..|..:.:.....::..|.:::....:.:.|.:|....|.::.
Mouse   366 SILDFCTNQHLFKVVLAIGCVWFTVSYISFTLNLKMNDFGLDVYFVQMVRSIVAVPARLCCIILL 430

  Fly   362 KYLGRKKTL-----LLSNGCSALGLILLACLSTQAEAVRVTCATIGLFGASITFPNVYLYGGELF 421
            :|.|||..|     |:::.|     :.|..|..:.::..:....:..|..:.|....::|..||.
Mouse   431 EYFGRKWALNLTLFLVTSMC-----LFLLFLPQEPKSTIILTLMLAEFSMAGTLSIFFIYTAELL 490

  Fly   422 PTVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVAPLIF-GIFSILAMLGTIFLPETRGTPLP 485
            |||:||:|:|:.|:....|:|.:..|.......|   |:.| .:..:||:..:..:|||....|.
Mouse   491 PTVLRSTGLGMVSLAWVAGAISSVAIFKQTKTQL---PIFFCCLCCVLALCFSSLVPETGSQSLR 552

  Fly   486 ETLE 489
            :::|
Mouse   553 DSIE 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	105/430 (24%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	100/418 (24%)
Slc22a14	NP_001032838.1	2A0119	59..553	CDD:273328	122/514 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.880