DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and Slc22a20

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_941052.1	Gene:	Slc22a20 / 381203	MGIID:	2685809	Length:	556	Species:	Mus musculus

Alignment Length:	532	Identity:	170/532 - (31%)
Similarity:	263/532 - (49%)	Gaps:	58/532 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 IISQIGDFRRYQLFFFFIVLLCKFGTGWHTLGHIFLAAPTPLSCK--------TENVT------- 73
            ::..:|...|:||.:..::||.......||....|.||..|..|:        |.||:
Mouse     6 LLDALGGVGRFQLVYTALLLLPCGLLACHTFLQNFTAAAPPHHCQHPANYTEPTTNVSGVWLRAA 70

  Fly    74 ---------DPC---------------------SDECSE-TEFDTSVFQSTIITEWNLTCESKQL 107
                     :||                     ::.|.: ..:|.|:|.|||:.||:|.||::.|
Mouse    71 IPLNQHGDPEPCRRYVEPQWALLKPNASSHGVATEGCKDGWVYDRSIFPSTIVMEWDLVCEARTL 135

  Fly   108 ASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQL-ITGLIVCVSPYYWFYCLFRFLVAV 171
            ..|:|||.|.|:|.|:.|||..|||.||: |.|...::|| ::|........:..||:||||:.:
Mouse   136 RDLAQSIYMSGVLVGAALFGGLADRLGRK-APLVWSYLQLAVSGAATAYVGSFSAYCVFRFLMGM 199

  Fly   172 ATAGTMTTSFVLLMEIVGPKKREMVAILYQIPFNIGHASLALFAYFIREWRWFQFSITIFSIVFV 236
            ..:|.:..|..|::|.:..:.|.:..||....|.:|...||..||.||.|||.||:::...:||.
Mouse   200 TFSGIILNSLSLVVEWMPTRGRTVAGILLGFSFTLGQLILAGVAYLIRPWRWLQFAVSAPFLVFF 264

  Fly   237 IYIWLVPESPRWLFTTGKLDKSIKILEKIAKCN--KAPTETIRPEIEAAYGALAARQPVKKGTVV 299
            :|.|.:|||.|||...||..::::.|:|:|..|  ||..|.:..|:.::|............:::
Mouse   265 LYSWWLPESSRWLLLHGKAQQAVQNLQKVAMMNGRKAEGERLTTEVVSSYIQDEFASVRTSNSIL 329

  Fly   300 DLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAGVGIPGTCLCALMTKYL 364
            ||||||.:|..|..:...|....:.|||.|..:...|.:|::..|:...:.||...:......|:
Mouse   330 DLFRTPAIRRVTCCLMGVWFSNSVAYYGLAMDLQKFGLSIYLVQALFGIIDIPAMLVATTTMIYV 394

  Fly   365 GRKKTLLLSNGCSALGLILLA--CLSTQAEAVRVTCATIGLFGASITFPNVYLYGGELFPTVVRS 427
            ||:.|  :|:.....||:::|  .:....:.:|...|.:|....:.:|..|||:.|||:||.:|.
Mouse   395 GRRAT--VSSFLILAGLMVIANMFMPEDLQTLRTVQAALGKGCLASSFICVYLFTGELYPTEIRQ 457

  Fly   428 SGVGLCSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSILA-MLGTIFLPETRGTPLPET---L 488
            .|:|..|:..|:|.:|||||..|......:.|:.||..|:|| |....||.|||..||.||   :
Mouse   458 MGMGFASVNARLGGLVAPLITTLGEISPVLPPVSFGATSVLAGMAVACFLTETRNVPLVETIAAM 522

  Fly   489 EDGETFGRKKKD 500
            |.....||.|:|
Mouse   523 ERRVKQGRSKRD 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	144/407 (35%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	137/395 (35%)
Slc22a20	NP_941052.1	2A0119	11..518	CDD:273328	163/509 (32%)
		MFS	138..507	CDD:119392	125/371 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	526..556		4/9 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.050