DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and CG4324

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001286807.1	Gene:	CG4324 / 37830	FlyBaseID:	FBgn0034956	Length:	478	Species:	Drosophila melanogaster

Alignment Length:	471	Identity:	120/471 - (25%)
Similarity:	198/471 - (42%)	Gaps:	79/471 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 FGTGWHTLGHIFLAAPTPLSCKTENVTDPCSDECSETEFDTSVFQSTIITEWNLTCESKQLASLS 111
            ||.||.   |:.|:....|...::::....          .|:...::..|||:|  ..|.||::
  Fly    49 FGFGWF---HVKLSLLVGLCWMSDSMEMAI----------LSILGPSLFCEWNVT--KFQQASVT 98

  Fly   112 QSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGLIVCVSPYYWFYCLFRFLVAVATAGT 176
             ::|.||::..|..:...::||||:.|......:.::..::..|:|.|.:....|.||..| .|.
  Fly    99 -TVVFLGMMLSSSFWTQLSNRYGRKSALTLFGVLLVLYSILSSVAPSYAWLLTLRGLVGFA-IGC 161

  Fly   177 MTTSFVLLMEIVGPKKREMVAILYQIPFNIG---HASLALFAYFIREWR-WFQFSITIFSIVFVI 237
            :..|..|..|.:..|.:....:|....:.:|   ...|||..|....|| ....|.|...|..::
  Fly   162 VPQSVTLYAEFLPTKHKGKCVVLMDCFWALGACFEVVLALVVYPYYGWRGLLALSATPLLIFTIL 226

  Fly   238 YIWLVPESPRWLFTTGKLDKSIKILEKIAKCNKAPTETIRPEIEAAYGALAARQPVKKGTVVDLF 302
            ..|| .||.|:....|..||:||:||:||..||.         ....|.|.|..   :.:..:.|
  Fly   227 SPWL-SESARYYSYNGHNDKAIKVLEQIAHNNKR---------HMLMGRLMADD---EPSCAESF 278

  Fly   303 R---TPYMRIKTIFMANNWLVVCMVYYG-------------------------TAQYVSALGGNI 339
            |   :|.:...||.:...||.....|||                         |:.::..|.  |
  Fly   279 RSLLSPSLYRTTILLWFLWLASAFCYYGLVLVTTELLVARNKESHPNECVTFMTSDFMDLLW--I 341

  Fly   340 FISNAIAAGVGIPGTCLCALMTKYLGRKKTLLLSNGCSALGLILLACLSTQAEAVRVTCATIGLF 404
            .:|.       .||..|...:.|..|:|||::|    ..|.|:|...:....|:...|..|:.:.
  Fly   342 TLSE-------FPGILLTIKVVKLFGKKKTIVL----QYLALVLCTLVLMSVESRFSTSVTLFIA 395

  Fly   405 GASIT--FPNVYLYGGELFPTVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWV-APLIFGIFS 466
            ..:|:  |..:|:|..|::|..:||.||..||::.|:|:::.|.:..:......: |...:.|..
  Fly   396 RGTISGIFQAIYVYTPEIYPAALRSVGVSGCSVLARLGAMLTPFVAQVLMDSSRIQAMSTYAIVG 460

  Fly   467 ILAMLGTIFLP-ETRG 481
            :||.:..:||| ||.|
  Fly   461 LLASIACVFLPRETVG 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	113/433 (26%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	108/424 (25%)
CG4324	NP_001286807.1	2A0119	10..476	CDD:273328	119/469 (25%)
CG4324	NP_001286807.1	MFS	60..471	CDD:119392	109/450 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.040