DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and CG4630

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster

Alignment Length:	578	Identity:	164/578 - (28%)
Similarity:	268/578 - (46%)	Gaps:	114/578 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DPIISQIGDFRRYQLFFFFIVLL---------------------------------CKFGTGWHT 53
            |.|:.:||:|.|:|...:.::.|                                 .::|..|.:
  Fly    16 DDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDAEYGANWVS 80

  Fly    54 L---------GHIFLAAPTPLSCK--------TENVTDPCS----DECSETEFDTS-------VF 90
            :         ||.     ||.:|:        .|:.:||.|    |:|....|.|.       |:
  Fly    81 IAVPGSWSKRGHF-----TPSTCERFVANGDHLESSSDPWSAWPLDQCFAENFTTETERCNQFVY 140

  Fly    91 QS---TIITEWNLTCESK--QLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITG 150
            .|   ||:.:|.|.|...  :||.:. :|...|::.|:.|.|..||||||:..||.|.....:||
  Fly   141 GSSERTIVQQWGLQCPENLWKLAFVG-TIHFAGLVVGTALSGYLADRYGRKHIFLFCIVFMALTG 204

  Fly   151 LIVCVSPYYWFYCLFRFLVAVATAGTMTTSFVLLMEIVGPKKREMVAILYQIPFNIGHASLALFA 215
            :...:|..|..:..|..|.||.|:|....:|::.:|:|||:||||.:|:....:.:|.|.|.| :
  Fly   205 VAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNYFYAVGEALLGL-S 268

  Fly   216 YFIREWRWFQFSITIFSIVFVIYIWLVPESPRWLFTTGKLDKSIKILEKIAKCNKAPTETIRPEI 280
            .|:.:||..|.::::..::.|.|.||||||.|||....:.:::..|:.:.||.|:   ..|..|:
  Fly   269 VFLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVNR---RDISVEL 330

  Fly   281 EAAY----------------GALAARQPVKKGTVV-DLFRTPYMRIKTIFMANNWLVVCMVYYGT 328
            .|::                |.|..::..|....| ::.|:..:..:...:...|.|..:||||.
  Fly   331 MASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAILLLIWAVNAIVYYGL 395

  Fly   329 AQYVSALGGNIFISNAIAAGVGIPGTCLCALMTKYLGRK-----KTLLLSNGCSALGLILLA--- 385
            :...::|.||.:::.|:...|.|||..|..|..:..||:     ..||.|..|.|.|.:.||
  Fly   396 SLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSITCVASGFVTLAQGD 460

  Fly   386 ---CLSTQAEA---------VRVTCATIGLFGASITFPNVYLYGGELFPTVVRSSGVGLCSMVGR 438
               | .|..|:         :.||...:|..|.:.:|..:|.:..|:.|||:||.|||:.|...|
  Fly   461 WIPC-QTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSGGVGVMSTFAR 524

  Fly   439 IGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLGTIFLPETRGTPLPETLEDGETFGR 496
            .|:::||.:..||:|...:..|:||..|::|.|.::.||||....||:|:|:....|:
  Fly   525 FGAMLAPFVPLLASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTVEEAIALGK 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	140/450 (31%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	133/438 (30%)
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	158/560 (28%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	116/380 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	1	0.900	-	-		E33208_3B9N9
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I1021
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	8	7.970