DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and Balat

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_610823.1	Gene:	Balat / 36417	FlyBaseID:	FBgn0033778	Length:	604	Species:	Drosophila melanogaster

Alignment Length:	566	Identity:	156/566 - (27%)
Similarity:	242/566 - (42%)	Gaps:	125/566 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DPIISQIGDFRRYQLFFFFIVLL-----CKFGTGWHTLGHIFLAAPTPLSCK------------- 68
            |.::.::|.|..||......|||     |.|    |....:|:||.....|:
  Fly     4 DEVLREVGSFGLYQKVIICSVLLPAALPCAF----HAYSQLFIAATPQHFCRVPELEPWTQDYVQ 64

  Fly    69 ---------------------TENVTD--------------------------------PCSDEC 80
                                 :.|.||                                ||.
  Fly    65 LVKNLSIPRNRNGAYAECSMYSRNYTDIVRYLEYRPPPDLLRQQAEDLLKLQPDTTQVVPCQ--- 126

  Fly    81 SETEFDTSVFQSTIITEWNLTCESKQLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFM 145
            ....:|.|::.||::.||||.|:...|.:|:..:..:|.|.|:.:||...|.:||||:|    :.
  Fly   127 HGWHYDKSIYSSTVVQEWNLVCDRSFLVTLALVVFGVGGLLGNYVFGYLVDLWGRRPSF----YA 187

  Fly   146 QLITGLIVC-VSPYYWFYCLF---RFLVAVATAGTMTTSFVLLMEIVGPKKREMVAILYQIPFNI 206
            .|:..:|.| .|.:.|.|..:   ||:|.:.....:.:.:||.:|:|||::|....|:..|.:::
  Fly   188 YLLLEIIACAASAFAWNYYTWLGLRFVVGLTVPAILASPYVLAIELVGPERRVFCTIVSNIAYSL 252

  Fly   207 GHASLALFAYFIREWRWFQFSIT-----IFSIVFVIYIWLVPESPRWLFTTGKLDKSIKILEKIA 266
            |...||...|.:|:||....:::     :||..||:     |||||||...||..::||||:.:|
  Fly   253 GLVVLAGVIYIVRDWRELSLAVSMPLLMLFSCFFVL-----PESPRWLMAVGKTRRAIKILKVMA 312

  Fly   267 -----KCNKAPTETIRPEIEAAYGALAARQPVKKGTVVDLFRTPYMRIKTIFMANNWLVVCMVYY 326
                 :.|:...|.::.::.....|...........::||||.|.||.||:.:...|.....||.
  Fly   313 RVNGVRVNRDFVERLQRKLVITRAAETKSSMTTHYGILDLFRGPNMRRKTLIITLIWFANTSVYV 377

  Fly   327 GTAQYVSALGGNIFISNAIAAGVGIPGTCLCALMTKYLGRKKTLLLSN-----GCSALGL----- 381
            |.:.|..||||:...:..:|..|.:|...|......|.||:..|.:|.     .|.|..|
  Fly   378 GLSYYAPALGGDEIWNFFLAGAVELPTYLLLWPGLSYFGRRWILFISMLVGGVACVATFLYPDIT 442

  Fly   382 ILLACLSTQAEAVRVTCATIGLFGASITFPNVYLYGGELFPTVVRSSGVGLCSMVGRIGSIVAPL 446
            :||.|              :|..|.|.:|..:.|...||:|||||..|:...|::..:|.||.|:
  Fly   443 LLLYC--------------VGKMGISSSFVVLPLMASELYPTVVRGLGMSFSSVISMVGPIVIPM 493

  Fly   447 IVDLAAYGLWVAPLIFGIFSILAMLGTIFLPETRGTPLPETLEDGE 492
            |..:....|.:..::.|...||....::.|||||...||:|||:||
  Fly   494 INHMGQQMLVLPLIVMGALLILGGFASLLLPETRNRNLPQTLEEGE 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	131/425 (31%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	123/413 (30%)
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	124/418 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	225	1.000	Domainoid score	I682
eggNOG	1	0.900	-	-		E33208_3B9N9
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I1021
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm8406
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
	9	8.990