DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and Slc22a14

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001101663.2	Gene:	Slc22a14 / 316061	RGDID:	1306470	Length:	630	Species:	Rattus norvegicus

Alignment Length:	539	Identity:	134/539 - (24%)
Similarity:	222/539 - (41%)	Gaps:	80/539 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 IISQIGDFRRYQLFFFFIVLLCKFGTGWHTLGHIFLAAPTPLSCKTE---------------NVT 73
            ::..||:|..:|.....:..:....:.:..|.|.||.......|.|.               |:|
  Rat    54 VLGAIGEFGTFQWRLVALTFIPSILSTFFLLSHHFLLTAQRPYCNTSWILQVGPNLTEDEQLNLT 118

  Fly    74 DP---------C--------------------SDECSETEFDTSVFQSTIITEWNLTCESKQLAS 109
            .|         |                    ::.|............::..|::|.|.::....
  Rat   119 VPRAPNGSFLTCLMYIPVPWDLDSIVHFGLNYTETCKHGWIYPFAHTRSLTNEFDLVCGNEPHEE 183

  Fly   110 LSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGLIVCVSPYYWFYCLFRFLVAVATA 174
            ..|::.:.|||.||:|||..:|:.||.|..|......||.|........::.|..|||.||.|:.
  Rat   184 NGQTVFLSGILTGSLLFGFLSDKLGRYPIILLSLLGILIFGFGTAFVNSFYQYLFFRFFVAQASV 248

  Fly   175 GTMTTSFVLLMEIVGPKKREMVAILYQIPFNIGHASLALFAYFIREWR--WFQFSITIFSIVFVI 237
            |....|..|:||.:..:.|....||....|.||...|..|||.|..||  :....:.:|.:  :.
  Rat   249 GYAICSVSLVMEWLVGEHRAQAIILQHCFFTIGVILLTGFAYKINHWRLLFLLGGVPMFPL--IC 311

  Fly   238 YIWLVPESPRWLFTTGKLDKSIKILEKIAKCNK--APTETIRPEIEAAYGALAARQPVK--KGTV 298
            .||::.||||||...||::::.|:|...|:.||  .|...:. |::.         |.|  |.::
  Rat   312 NIWVLQESPRWLMVKGKVEEAKKVLCYAAEVNKKTIPLNLLN-ELQL---------PGKKAKASI 366

  Fly   299 VDLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAGVGIPGTCLCALMTKY 363
            :|.:...::....:.|...|..|..|....:..:...|.:|:....:.....:|....|.|:.:|
  Rat   367 LDFYTNQHLFKVVLAMGCVWFTVSYVSLTLSLKMKDFGLDIYFIQVVPCITAVPARLCCILLLEY 431

  Fly   364 LGRKKTLLLSNGCSALGLILLACLS-----TQAEAVRVTCATIGLFGASITFPNVYLYGGELFPT 423
            .|||.:|.|:     |.|:...|||     .:.::..:....:|.|..:.|....::|..||.||
  Rat   432 FGRKWSLNLT-----LSLVTFTCLSLLFVPEELKSTTILMLVLGEFSMAGTVSIFFIYTAELLPT 491

  Fly   424 VVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVAPLIF-GIFSILAMLGTIFLPETRGTPLPET 487
            ::||:|:|:.|:....|:|.:..|.......|   |:.| .:..|||:..:..:|||...||.::
  Rat   492 ILRSTGLGMVSIAWTAGAISSLAIFKQTKTQL---PIFFCCLCCILALCFSSLVPETGNQPLRDS 553

  Fly   488 LE----DGETFGRKKKDQA 502
            :|    |......|.||.:
  Rat   554 IEYCSRDSLEHKDKSKDSS 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	114/413 (28%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	109/401 (27%)
Slc22a14	NP_001101663.2	MFS	147..527	CDD:421695	106/399 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110