DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and Slc22a4

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_062661.1	Gene:	Slc22a4 / 30805	MGIID:	1353479	Length:	553	Species:	Mus musculus

Alignment Length:	540	Identity:	143/540 - (26%)
Similarity:	246/540 - (45%)	Gaps:	73/540 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DPIISQIGDFRRYQLFFFFIVLLCKFGTGWHTLGHIFLAA------------------------- 61
            |.:|:.:|::..:|...||::.......|::.:..:|||.
Mouse     5 DEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCLVPDTVNLSSSWRNHSIPL 69

  Fly    62 ------PTPLSCKTENVT----------DPCSD---------ECSE-TEFDTSVFQSTIITEWNL 100
                  ..|.||:...:.          :|..|         .|.: .|:|..:|.|||:|||||
Mouse    70 ETKDGRQVPQSCRRYRLATIANFSAMGLEPGQDVDLEQLEQESCLDGWEYDKDIFLSTIVTEWNL 134

  Fly   101 TCESKQLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGLIVCVSPYYWFYCLF 165
            .||......|:.|:..:|:|.||.:.|..:||:||:........:|.....:...|..:..:.:.
Mouse   135 VCEDDWKTPLTTSLFFVGVLCGSFVSGQLSDRFGRKKVLFATMAVQTGFSFVQIFSTNWEMFTVL 199

  Fly   166 RFLVAVATAGTMTTSFVLLMEIVGPKKREMVAILYQIP-FNIGHASLALFAYFIREWRWFQFSIT 229
            ..:|.:........:|:|..||:....|.:.:.|.... |.||:..|.|||||||:||....::|
Mouse   200 FAIVGMGQISNYVVAFILGTEILSKSVRIIFSTLGVCTFFAIGYMVLPLFAYFIRDWRMLLLALT 264

  Fly   230 IFSIVFVIYIWLVPESPRWLFTTGKLDKSIKILEKIAKCNK--APTETIRP-EIEAAYGALAARQ 291
            :..:..|...|.:|||||||.:..:..::.:|::|.||.|.  ||.....| |::...   :.:|
Mouse   265 LPGLFCVPLWWFIPESPRWLISQRRFAEAEQIIQKAAKMNSIVAPAGIFDPLELQELN---SLKQ 326

  Fly   292 PVKKGTVVDLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAGVGIPGTCL 356
              :|..::|||||..:...|:.....|::..:.|:..:..|..|.|:::::..::..:.:|....
Mouse   327 --QKVIILDLFRTRNIATITVMAVMLWMLTSVGYFALSLNVPNLHGDVYLNCFLSGLIEVPAYFT 389

  Fly   357 CALMTKYLGRK----KTLLLSNGCSALGLILLACLSTQAEAVRVTCATIGLFGASITFPNVYLYG 417
            ..|:.:.|.|:    ..|....|.    |:|:..:......|.:....:|.||.:..|..:|::.
Mouse   390 AWLLLRTLPRRYIIAGVLFWGGGV----LLLIQVVPEDYNFVSIGLVMLGKFGITSAFSMLYVFT 450

  Fly   418 GELFPTVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLGTIFLPETRGT 482
            .||:||:||:..||:.||..|:|||:||..|.|.||...:..::.|..::|..:.|:|.||:.|.
Mouse   451 AELYPTLVRNMAVGITSMASRVGSIIAPYFVYLGAYNRLLPYILMGSLTVLIGIITLFFPESFGV 515

  Fly   483 PLPETLED-----GETFGRK 497
            .|||.||.     |...|:|
Mouse   516 TLPENLEQMQKVRGFRCGKK 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	120/409 (29%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	114/397 (29%)
Slc22a4	NP_062661.1	2A0119	12..519	CDD:273328	134/515 (26%)
Slc22a4	NP_062661.1	MFS	123..510	CDD:119392	114/395 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.940