DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and Slc22a5

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_062142.1	Gene:	Slc22a5 / 29726	RGDID:	3702	Length:	557	Species:	Rattus norvegicus

Alignment Length:	532	Identity:	151/532 - (28%)
Similarity:	253/532 - (47%)	Gaps:	78/532 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DPIISQIGDFRRYQLFFFFIVLLCKFGTGWHTLGHIFLAA------------------------- 61
            |.:.:.:|::..:|...||::.......|::.:..:|||.
  Rat     5 DEVTAFLGEWGPFQRLIFFLLSASIIPNGFNGMSIVFLAGTPEHRCLVPHTVNLSSAWRNHSIPL 69

  Fly    62 ------PTPLSCKTENVT----------DPCSD---------ECSE-TEFDTSVFQSTIITEWNL 100
                  ..|.||:...:.          :|..|         .|.: .|::..||.|||:|||:|
  Rat    70 ETKDGRQVPQSCRRYRLATIANFSALGLEPGRDVDLEQLEQENCLDGWEYNKDVFLSTIVTEWDL 134

  Fly   101 TCESKQLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGLIVCVSPYYWFYCLF 165
            .|:....|.|:.|:..:|:|.||.:.|..:||:||:........||.....:...|..:..:.:.
  Rat   135 VCKDDWKAPLTTSLFFVGVLMGSFISGQLSDRFGRKNVLFLTMGMQTGFSFLQLFSVNFEMFTVL 199

  Fly   166 RFLVAVATAGTMTTSFVLLMEIVGPKKREM-----VAILYQIPFNIGHASLALFAYFIREWRWFQ 225
            ..||.:........:|||..||:....|.:     |.|.|...|.:    |.|||||||:||...
  Rat   200 FVLVGMGQISNYVAAFVLGTEILSKSIRIIFATLGVCIFYAFGFMV----LPLFAYFIRDWRMLL 260

  Fly   226 FSITIFSIVFVIYIWLVPESPRWLFTTGKLDKSIKILEKIAKCN--KAPTETIRP-EIEAAYGAL 287
            .::|:..::.....|.:|||||||.:.|::.::..|:.|.||.|  .||:....| |::    .|
  Rat   261 LALTVPGVLCGALWWFIPESPRWLISQGRVKEAEVIIRKAAKFNGIVAPSTIFDPSELQ----DL 321

  Fly   288 AARQPVKKGTVVDLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAGVGIP 352
            .:::| :...:.||.||..:||.||.....||.:.:.|:|.:.....|.|:|:::..:.|.|.:|
  Rat   322 NSKKP-QSHHIYDLVRTRNIRIITIMSIILWLTISVGYFGLSLDTPNLHGDIYVNCFLLAAVEVP 385

  Fly   353 GTCLCALMTKYLGRKKTLLLSNGCSAL---GLILLACLSTQAEAVRVTCA--TIGLFGASITFPN 412
            ...|..|:.::|.|:.::     .:||   |.:||......:|...::.|  .:|.||.:..:..
  Rat   386 AYVLAWLLLQHLPRRYSI-----SAALFLGGSVLLFIQLVPSELFYLSTALVMVGKFGITSAYSM 445

  Fly   413 VYLYGGELFPTVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLGTIFLP 477
            ||:|..||:|||||:.|||:.|...|:|||::|..|.|.||..::..::.|..:||..:.|:|.|
  Rat   446 VYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFFP 510

  Fly   478 ETRGTPLPETLE 489
            |:.|.|||:|::
  Rat   511 ESFGAPLPDTID 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	134/414 (32%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	128/402 (32%)
Slc22a5	NP_062142.1	2A0119	12..520	CDD:273328	149/521 (29%)
		MFS	123..510	CDD:119392	128/400 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..557
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.910