DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8654 and Sv2c

DIOPT Version :10

Sequence 1:NP_611451.1 Gene:CG8654 / 37275 FlyBaseID:FBgn0034479 Length:502 Species:Drosophila melanogaster
Sequence 2:NP_113781.1 Gene:Sv2c / 29643 RGDID:619718 Length:727 Species:Rattus norvegicus


Alignment Length:638 Identity:122/638 - (19%)
Similarity:198/638 - (31%) Gaps:237/638 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 IISQIGDFR-RYQLFFFFIVLLCKFGTGWHTLGHIFLAAPTPLSCKTENVTDPCSDECSETEFDT 87
            ||.:.|..| ::.|||...:.|...|.....:|.:..:|.|.|                      
  Rat   141 IIQECGHGRFQWALFFVLGMALMADGVEVFVVGFVLPSAETDL---------------------- 183

  Fly    88 SVFQSTIITEWNLTCESKQLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGLI 152
                          |.....:....|||.||::.|:..:|..||:.||:.:.|.|   ..:.|..
  Rat   184 --------------CIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLIC---MSVNGFF 231

  Fly   153 VCVSPY---YWFYCLFRFLVAVATAGTMTTSFVLLMEIVGPKKRE----------MVAILYQ--- 201
            ..:|.:   |.|:.|.|.|......|.:.|.|....|::..:||.          |:..:|.   
  Rat   232 AFLSSFVQGYGFFLLCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAM 296

  Fly   202 ----IP-----FNIGHASLALFAYFIREWRWFQFSITIFSIVFVIYIWLVPESPRWLFTTGKLDK 257
                ||     |::|.      ||....||.|.....:..:..|:.:..:|||||:|...||.|:
  Rat   297 AWAIIPHYGWSFSMGS------AYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDE 355

  Fly   258 SIKIL--------------EKIAKCNKAPT-----ETIRPEIEAAYGALAARQPVKKG------- 296
            :..||              ||:...||..|     |.|  |||:..|....|..|:..       
  Rat   356 AWMILKLIHDTNMRARGQPEKVFTVNKIKTPKQIDELI--EIESDTGTWYRRCFVRIRTELYGIW 418

  Fly   297 -TVVDLFRTPYMRIKTIFMANNWLVVCMVYYG--------------------------------- 327
             |.:..|..| :|..||.:...|..:...|||                                 
  Rat   419 LTFMRCFNYP-VRENTIKLTIVWFTLSFGYYGLSVWFPDVIKHLQSDEYALLTRNVQKDKYANFS 482

  Fly   328 ---------------------------------------------------TAQYVSALGGN--- 338
                                                               ...::..|..|   
  Rat   483 INFTMENQVHTGMEYDNGRFLGVKFKSVTFKDSVFKSCTFDDVTSVNTYFKNCTFIDTLFENTDF 547

  Fly   339 ----------------------------------IFISNAIAAGVGIPGTCLCALMTKYLGRKKT 369
                                              |:..|.:.....:||..:.||:...:||...
  Rat   548 EPYKFIDSEFQNCSFLHNKTGCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTM 612

  Fly   370 LLLSNGCSALGLILLACLSTQAEAVRVTCATIGLFGASITFPNVYLYGGELFPTVVRSSGVG--- 431
            |..|...|.:....|...::::..:.:.|...||..::....:|...  ||:||..|::|.|   
  Rat   613 LGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTV--ELYPTDRRATGFGFLN 675

  Fly   432 -LCSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLGTIF---LPETR 480
             ||.....:|:::...:|.:..    ..|::  :.|.:.:.|.:.   ||:||
  Rat   676 ALCKAAAVLGNLIFGSLVSITK----AIPIL--LASTVLVCGGLVGLRLPDTR 722

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8654NP_611451.1 MFS_SLC22 82..477 CDD:340875 105/574 (18%)
Sv2cNP_113781.1 synapt_SV2 1..727 CDD:130366 122/638 (19%)
Interaction with SYT1. /evidence=ECO:0000269|PubMed:15866046 1..57
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 22..120
(Microbial infection) C.botulinum neurotoxin type A-binding. /evidence=ECO:0000269|PubMed:16543415, ECO:0000269|PubMed:27294781 529..566 2/36 (6%)
Blue background indicates that the domain is not in the aligned region.

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