DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and Sv2c

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_113781.1	Gene:	Sv2c / 29643	RGDID:	619718	Length:	727	Species:	Rattus norvegicus

Alignment Length:	638	Identity:	122/638 - (19%)
Similarity:	198/638 - (31%)	Gaps:	237/638 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 IISQIGDFR-RYQLFFFFIVLLCKFGTGWHTLGHIFLAAPTPLSCKTENVTDPCSDECSETEFDT 87
            ||.:.|..| ::.|||...:.|...|.....:|.:..:|.|.|
  Rat   141 IIQECGHGRFQWALFFVLGMALMADGVEVFVVGFVLPSAETDL---------------------- 183

  Fly    88 SVFQSTIITEWNLTCESKQLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGLI 152
                          |.....:....|||.||::.|:..:|..||:.||:.:.|.|   ..:.|..
  Rat   184 --------------CIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLIC---MSVNGFF 231

  Fly   153 VCVSPY---YWFYCLFRFLVAVATAGTMTTSFVLLMEIVGPKKRE----------MVAILYQ--- 201
            ..:|.:   |.|:.|.|.|......|.:.|.|....|::..:||.          |:..:|.
  Rat   232 AFLSSFVQGYGFFLLCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAM 296

  Fly   202 ----IP-----FNIGHASLALFAYFIREWRWFQFSITIFSIVFVIYIWLVPESPRWLFTTGKLDK 257
                ||     |::|.      ||....||.|.....:..:..|:.:..:|||||:|...||.|:
  Rat   297 AWAIIPHYGWSFSMGS------AYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDE 355

  Fly   258 SIKIL--------------EKIAKCNKAPT-----ETIRPEIEAAYGALAARQPVKKG------- 296
            :..||              ||:...||..|     |.|  |||:..|....|..|:..
  Rat   356 AWMILKLIHDTNMRARGQPEKVFTVNKIKTPKQIDELI--EIESDTGTWYRRCFVRIRTELYGIW 418

  Fly   297 -TVVDLFRTPYMRIKTIFMANNWLVVCMVYYG--------------------------------- 327
             |.:..|..| :|..||.:...|..:...|||
  Rat   419 LTFMRCFNYP-VRENTIKLTIVWFTLSFGYYGLSVWFPDVIKHLQSDEYALLTRNVQKDKYANFS 482

  Fly   328 ---------------------------------------------------TAQYVSALGGN--- 338
                                                               ...::..|..|
  Rat   483 INFTMENQVHTGMEYDNGRFLGVKFKSVTFKDSVFKSCTFDDVTSVNTYFKNCTFIDTLFENTDF 547

  Fly   339 ----------------------------------IFISNAIAAGVGIPGTCLCALMTKYLGRKKT 369
                                              |:..|.:.....:||..:.||:...:||...
  Rat   548 EPYKFIDSEFQNCSFLHNKTGCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTM 612

  Fly   370 LLLSNGCSALGLILLACLSTQAEAVRVTCATIGLFGASITFPNVYLYGGELFPTVVRSSGVG--- 431
            |..|...|.:....|...::::..:.:.|...||..::....:|...  ||:||..|::|.|
  Rat   613 LGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTV--ELYPTDRRATGFGFLN 675

  Fly   432 -LCSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLGTIF---LPETR 480
             ||.....:|:::...:|.:..    ..|::  :.|.:.:.|.:.   ||:||
  Rat   676 ALCKAAAVLGNLIFGSLVSITK----AIPIL--LASTVLVCGGLVGLRLPDTR 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	109/576 (19%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	105/569 (18%)
Sv2c	NP_113781.1	synapt_SV2	1..727	CDD:130366	122/638 (19%)
		Interaction with SYT1. /evidence=ECO:0000269\|PubMed:15866046	1..57
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..120
		MFS	155..719	CDD:119392	113/619 (18%)
		Pentapeptide_3	507..561	CDD:290309	2/53 (4%)
		(Microbial infection) C.botulinum neurotoxin type A-binding. /evidence=ECO:0000269\|PubMed:16543415, ECO:0000269\|PubMed:27294781	529..566		2/36 (6%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910