DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8654 and Slc22a20

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001381833.1	Gene:	Slc22a20 / 293686	RGDID:	1311460	Length:	556	Species:	Rattus norvegicus

Alignment Length:	532	Identity:	168/532 - (31%)
Similarity:	261/532 - (49%)	Gaps:	58/532 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 IISQIGDFRRYQLFFFFIVLLCKFGTGWHTLGHIFLAAPTPLSCK-----TE------------- 70
            ::..:|...|:||.:..::||.......||....|.||..|..|:     ||
  Rat     6 LLDALGGVGRFQLVYTALLLLPCGLLACHTFLQNFTAAAPPHHCQHPANYTEATTNDSGAWLRAT 70

  Fly    71 ------NVTDPC---------------------SDECSE-TEFDTSVFQSTIITEWNLTCESKQL 107
                  .|.:||                     ::.|.: ..:|.|:|.|||:.||:|.||::.|
  Rat    71 IPLNQHGVPEPCQRYTEPQWALLEPNTSSHGVATEGCKDGWVYDRSIFPSTIVMEWDLVCEARTL 135

  Fly   108 ASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQL-ITGLIVCVSPYYWFYCLFRFLVAV 171
            ..|:|||.|.|:|.|:.|||..|||.||: |.|...::|| ::|.:......:..||:||||:.:
  Rat   136 RDLAQSIYMSGVLVGAALFGSLADRLGRK-APLVWSYLQLAVSGAVTAYVGSFSAYCIFRFLMGM 199

  Fly   172 ATAGTMTTSFVLLMEIVGPKKREMVAILYQIPFNIGHASLALFAYFIREWRWFQFSITIFSIVFV 236
            ..:|.:..|..|::|.:..:.|.:..||....|.:|...||..||.||.|||.||:::...:||.
  Rat   200 TFSGIILNSLSLVVEWMPTRGRTVAGILLGFSFTLGQLILAGVAYLIRPWRWLQFAVSAPFLVFF 264

  Fly   237 IYIWLVPESPRWLFTTGKLDKSIKILEKIAKCN--KAPTETIRPEIEAAYGALAARQPVKKGTVV 299
            :|.|.:|||.|||...||..::::.|.|:|..|  ||..|.:..|:.::|............:::
  Rat   265 LYSWWLPESSRWLLLHGKAQQAVQNLRKVAMMNGRKAEGERLTIEVVSSYIQNEFASVRTSNSIL 329

  Fly   300 DLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAGVGIPGTCLCALMTKYL 364
            ||||||.:|..|..:...|....:.|||.|..:...|.:|::..|:...:.||...:......|:
  Rat   330 DLFRTPGIRKVTCCLMMVWFSNSVAYYGLAMDLQKFGLSIYLVQALFGIIDIPAMLVATTTMIYV 394

  Fly   365 GRKKTLLLSNGCSALGLILLA--CLSTQAEAVRVTCATIGLFGASITFPNVYLYGGELFPTVVRS 427
            ||:.|  :|:.....||:::|  .:....:.:|...|.:|....:.:|..|||:.|||:||.:|.
  Rat   395 GRRAT--VSSFLVLAGLMVIANMFVPEDLQTLRTVQAALGKGCLASSFICVYLFTGELYPTEIRQ 457

  Fly   428 SGVGLCSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLGTI-FLPETRGTPLPET---L 488
            .|:|..|:..|:|.:.||||..|......:.|:.||..|:||.:..| ||.|||..||.||   :
  Rat   458 MGMGFASVNARLGGLAAPLITTLGEISPVLPPVSFGATSVLAGMAVICFLTETRNVPLVETIAAM 522

  Fly   489 EDGETFGRKKKD 500
            |.....|..|:|
  Rat   523 ESRVKEGHSKRD 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	143/407 (35%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	136/395 (34%)
Slc22a20	NP_001381833.1	MFS_SLC22A6_OAT1_like	103..508	CDD:341004	138/407 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920