DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and Slc22a1

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_036829.1	Gene:	Slc22a1 / 24904	RGDID:	3224	Length:	556	Species:	Rattus norvegicus

Alignment Length:	543	Identity:	160/543 - (29%)
Similarity:	257/543 - (47%)	Gaps:	73/543 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 TGDPIISQIGDFRRYQLFFFFIVLLCKFGTGWHTLGHIFLAAPTPLSCKTENVTD---PC----- 76
            |.|.::.|:|:|..:|...|.::.|.........:|.:||.......|:...|.:   .|
  Rat     3 TVDDVLEQVGEFGWFQKQAFLLLCLISASLAPIYVGIVFLGFTPGHYCQNPGVAELSQRCGWSQA 67

  Fly    77 ------------SDECS--------ETEFDTSVFQ------------------------------ 91
                        |||.|        |.:::.|...
  Rat    68 EELNYTVPGLGPSDEASFLSQCMRYEVDWNQSTLDCVDPLSSLVANRSQLPLGPCEHGWVYDTPG 132

  Fly    92 STIITEWNLTCESKQLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGLIVCVS 156
            |:|:||:||.|.......|.||.|.||...||::.|..|||:||:...|....:..::|::..|:
  Rat   133 SSIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLVTSVSGVLTAVA 197

  Fly   157 PYYWFYCLFRFLVAVATAGTMTTSFVLLMEIVGPKKREMVAILYQIPFNIGHASLALFAYFIREW 221
            |.|....|||.|..:.:.|:..:.:.|:.|.||...|...|||||:.|.:|...||..||.|.:|
  Rat   198 PDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTAILYQMAFTVGLVGLAGVAYAIPDW 262

  Fly   222 RWFQFSITIFSIVFVIYIWLVPESPRWLFTTGKLDKSIKILEKIAKCN-KAPTETIRP---EIEA 282
            ||.|.::::.:.:|::|.|.||||||||.:..:..::::|:|:||:.| |.|...::.   |.:|
  Rat   263 RWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTRAVRIMEQIAQKNGKVPPADLKMLCLEEDA 327

  Fly   283 AYGALAARQPVKKGTVVDLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAA 347
            :    ..|.|    :..||||||.:|..|:.:...|....::|.|...:|.|.|.|:::....::
  Rat   328 S----EKRSP----SFADLFRTPNLRKHTVILMYLWFSCAVLYQGLIMHVGATGANLYLDFFYSS 384

  Fly   348 GVGIPGTCLCALMTKYLGRKKTLLLSNGCSALGLILLACLSTQAEAVRVTCATIGLFGASITFPN 412
            .|..|...:..:....:||...:..||..:....:|:..:..:...:.||.|.:|..||:|....
  Rat   385 LVEFPAAFIILVTIDRIGRIYPIAASNLVTGAACLLMIFIPHELHWLNVTLACLGRMGATIVLQM 449

  Fly   413 VYLYGGELFPTVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVA-PLI-FGIFSILAMLGTIF 475
            |.|...||:||.:|:.|:.:||.:..:|.|..|.:| .....:|.| ||| ||:..:.|...|:.
  Rat   450 VCLVNAELYPTFIRNLGMMVCSALCDLGGIFTPFMV-FRLMEVWQALPLILFGVLGLTAGAMTLL 513

  Fly   476 LPETRGTPLPETLEDGETFGRKK 498
            ||||:|..||||:|:.|..||:|
  Rat   514 LPETKGVALPETIEEAENLGRRK 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	134/437 (31%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	127/425 (30%)
Slc22a1	NP_036829.1	2A0119	12..525	CDD:273328	150/521 (29%)
Slc22a1	NP_036829.1	MFS	125..515	CDD:119392	126/398 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920