DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and Slc22a26

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	XP_017173677.1	Gene:	Slc22a26 / 236149	MGIID:	2385316	Length:	553	Species:	Mus musculus

Alignment Length:	552	Identity:	150/552 - (27%)
Similarity:	260/552 - (47%)	Gaps:	87/552 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 IISQIGDFRRYQLFFFFIVLLCKFGTGWH---------TLGH----------------------- 56
            :::.:|...|:|:.....:|:|...|..|         .|||
Mouse     6 LLNLVGSHGRFQILQMAFLLICNVITMPHVILENFTAANLGHRCWVHIIDNDTNSNNNSGILSQD 70

  Fly    57 --IFLAAP-----TPLSCKT---------------ENVTDPCSDECSE-TEFDTSVFQSTIITEW 98
              :.::.|     .|..|:.               .|:|:|.::.|.: ..:|...|.||.:|||
Mouse    71 DLLRISIPLDSNLRPEKCRRFVQPQWHLLQFNGSFSNMTEPDTEPCMDGWVYDQRTFLSTTVTEW 135

  Fly    99 NLTCESKQLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQL-ITGLIVCVSPYYWFY 162
            ||.|.|::|.|:::.|.::|:|.|..:.|..:|::||:..| .|..:|: |||....::|.::.|
Mouse   136 NLVCGSQELNSVAKFIFLIGVLAGHFVGGHLSDKFGRKLLF-RCALLQMAITGTCTALAPTFFIY 199

  Fly   163 CLFRFLVAVATAGTMTTSFVLLMEIVGPKKREMVAILYQIPFNIGHASLALFAYFIREWRWFQFS 227
            ||.|||..:......|.|.:|::|...||.:.:|..|.....:.|...||..|:..:.|...|.:
Mouse   200 CLLRFLTGLCIIPINTNSVLLMLEWTSPKTQALVTTLSMSSHHFGGLILAGLAFAFQNWHHLQLA 264

  Fly   228 ITIFSIVFVIYI----WLVPESPRWLFTTGKLDKSIKILEKIAKCN--KAPTETIRPEIEAAYGA 286
            |::  .:||:.|    ||. ||.|||..|.|..|:::.|.|:|..|  |...:.:..|:......
Mouse   265 ISV--PIFVLLIPTSRWLT-ESARWLIVTNKPQKALQELRKVASKNGIKNSEDVLTMEVVRTIMK 326

  Fly   287 LAARQPVKKGTVVDLFRTPYMRIKTIFMANNWLVVCMVYY-------GTAQYVSALGGNIFISNA 344
            .....|..|.::.|||..|.:|       ....::|::.:       |....:..|.||:|::.:
Mouse   327 DEIAIPRTKPSLRDLFHMPNLR-------KRLCLLCLLRFLQISPTVGINMNLQHLKGNVFLTQS 384

  Fly   345 IAAGVGIPGTCLCALMTKYLGRKKTLLLSNGCSALGLILLACLSTQAEAVRVTCATIGLFGAS-- 407
            :.:...||.|.|...:..|:||:.:.||.  |...|:.||:.:|...|...:....|.|.|.|
Mouse   385 LTSAFSIPATALGGFLLNYIGRRISQLLP--CLLFGIFLLSIVSVPQEMQTLLVVLITLAGGSSA 447

  Fly   408 ITFPNVYLYGGELFPTVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLG 472
            :.:.:..||..||.|||:|::.:|:..:.|.:|:.::|||:.|..|...:..:|:|:.|||..|.
Mouse   448 MIYNSNVLYSSELMPTVIRATALGVIGICGGVGAALSPLIMILTLYSASLPWIIYGVLSILGGLL 512

  Fly   473 TIFLPETRGTPLPETLED---GETFGRKKKDQ 501
            .:.||||:..|||::::|   |....::||::
Mouse   513 PLILPETKNQPLPDSIQDVECGWESSKQKKEE 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	129/417 (31%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	121/405 (30%)
Slc22a26	XP_017173677.1	MFS	109..506	CDD:391944	121/409 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D464838at2759
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020