DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and Slc22a19

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_659034.1	Gene:	Slc22a19 / 207151	MGIID:	2442751	Length:	551	Species:	Mus musculus

Alignment Length:	554	Identity:	160/554 - (28%)
Similarity:	255/554 - (46%)	Gaps:	97/554 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 IISQIGDFRRYQLFFFFIVLLCKFGTGWHTLGHIFLAA-PT------------------------ 63
            :|.|||...|:|:.....||:|...:..|||...|.|| |:
Mouse     6 LIIQIGSLGRFQILHMIFVLICHALSAPHTLLENFTAAIPSHRCWVPILDNDTASDNGSRILSQD 70

  Fly    64 --------------PLSCK-------------------TENVTDPCSDECSETEFDTSVFQSTII 95
                          |..|:                   ||..|:||.|   ...:|.|.|.||.:
Mouse    71 DLLRISIPLDSNLRPDKCRRYIQPQWHLLHLNGTFPTVTEPDTEPCVD---GWVYDQSTFLSTTV 132

  Fly    96 TEWNLTCESKQLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQL-ITGLIVCVSPYY 159
            |:|:|.|.|:.|.|:::.|.|.||..|.|:.|..:|::||:..| ||..::: ||...|..:|.:
Mouse   133 TQWDLVCGSQALNSVAKFIYMTGIFIGYIMGGHLSDKFGRKLIF-TCSLLKMAITETCVAFAPSF 196

  Fly   160 WFYCLFRFLVAVATAGTMTTSFVLLMEIVGPKKREMVAILYQIPFNIGHASLALFAYFIREWRWF 224
            ..||..|||..:.::...|.|.:|::|...||.:.:|..|..|...:|...|...|:..|.|...
Mouse   197 LIYCSLRFLSGIFSSTLRTNSALLILEWTSPKFQALVMALIFIASGVGQTLLGGLAFAFRNWHHL 261

  Fly   225 QFSITIFSIVFVIYI---WLVPESPRWLFTTGKLDKSIKILEKIAKCNKAP----------TETI 276
            |.::::  .:|::.|   || .||.|||....|..||:|.|:|.|..|:..          .:||
Mouse   262 QLALSV--PMFLLLIPTRWL-SESARWLIMANKPQKSLKELKKAACVNRIKNSGDALTLEVVKTI 323

  Fly   277 -RPEIEAAYGALAARQPVKKGTVVDLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIF 340
             :.|:|||.         .|.:.:||||||.:|.:...::....|..|...|....:..|..|:|
Mouse   324 MKEELEAAQ---------TKPSPLDLFRTPNLRKRICLLSFVRFVSVMSLLGLLINIQYLSNNVF 379

  Fly   341 ISNAIAAGVGIPGTCLCALMTKYLGRKKTLLLSNGCSALGLILLAC--LSTQAEAVRVTCATIG- 402
            :...:...|.||...|......|:||:.|.|:.  .|.||:.:||.  |..:.:.:||..:|:|
Mouse   380 LLQCLYGVVCIPANVLGNFSMNYMGRRMTQLIF--MSVLGISILAVVFLPQEMQILRVFLSTLGG 442

  Fly   403 -LFGASITFPNVYLYGGELFPTVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFS 466
             :..||||  :..::..||.||::|::.:|:..:.|..|..::||::.|..|...:..:|:||..
Mouse   443 AISSASIT--STLVHANELVPTIIRATALGVVGIAGSAGGALSPLLMILTTYSASLPWIIYGILP 505

  Fly   467 ILAMLGTIFLPETRGTPLPETLEDGETFGRKKKD 500
            .|..|..:.||||:..|||::::|.|...:..|:
Mouse   506 FLGGLVALLLPETKNQPLPDSIQDIENKRKSSKE 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	133/420 (32%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	125/408 (31%)
Slc22a19	NP_659034.1	Sugar_tr	11..525	CDD:331684	153/533 (29%)
Slc22a19	NP_659034.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	524..551		4/16 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D464838at2759
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020