Protein Alignment CG8654 and Slc22a3

DIOPT Version :10

• Sequence 1: NP_611451.1
• Gene: CG8654 / 37275
• FlyBaseID: FBgn0034479
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_035525.1
• Gene: Slc22a3 / 20519
• MGIID: 1333817
• Length: 551
• Species: Mus musculus
• Alignment Length: 551
• Identity: 181/551 - (32%)
• Similarity: 270/551 - (49%)
• Gaps: 77/551 - (13%)

  Fly    20 TGDPIISQIGDFRRYQLFFFFIVLLCKFGTGWHTL--GHIFLAA-PTPLSCKTE----------- 70
            |.|..:.:.|:|.|:|...|  :|||..|..:..|  |.:||.: |....|:..
Mouse     3 TFDQALRKAGEFGRFQRRVF--LLLCLTGVTFAFLFVGVVFLGSQPDYYWCRGPRATALAERCAW 65

  Fly    71 ------NVTDP--------------------CSDECSETEFD-TSVF------------------ 90
                  |:|.|                    .::..||...| .:.|
Mouse    66 SPEEEWNLTTPELHVPAERRGQGHCHRYLLEATNTSSELSCDPLTAFPNRSAPLVSCSGDWRYVE 130

  Fly    91 -QSTIITEWNLTCESKQLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGLIVC 154
             .|||:::::|.|.:..:..|:|:|:.||.|.|:...|..||||||...:|..||...|||::|.
Mouse   131 THSTIVSQFDLVCSNAWMLDLTQAILNLGFLAGAFTLGYAADRYGRLIIYLISCFGVGITGVVVA 195

  Fly   155 VSPYYWFYCLFRFLVAVATAGTMTTSFVLLMEIVGPKKREMVAILYQIPFNIGHASLALFAYFIR 219
            .:|.:..:.:||||..|...|...|.||::.||||.|:|.:|.|:.|:.|.:|...|...|||..
Mouse   196 FAPNFSVFVIFRFLQGVFGKGAWMTCFVIVTEIVGSKQRRIVGIVIQMFFTLGIIILPGIAYFTP 260

  Fly   220 EWRWFQFSITIFSIVFVIYIWLVPESPRWLFTTGKLDKSIKILEKIAKCNKAPTETIRPEIEAAY 284
            .|:..|.:|::.|.:|::|.|:||||||||.|..:.:|:::||.::||||.....:...||
Mouse   261 SWQGIQLAISLPSFLFLLYYWVVPESPRWLITRKQGEKALQILRRVAKCNGKHLSSNYSEI---- 321

  Fly   285 GALAARQPVKKGTVVDLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAGV 349
              ....:.|...:.:||.|||.||..|:.:...|....:||.|....:..:|||::|...|:..|
Mouse   322 --TVTDEEVSNPSCLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRLGLIGGNLYIDFFISGLV 384

  Fly   350 GIPGTCLCALMTKYLGRKKTLLLSNGCSALGLILLACLSTQAEAVRVTCATIGLFGASITFPNVY 414
            .:||..|..|..:.|||:.....||..:.:..::.|.|......:|.|.||:|..|.::.|..||
Mouse   385 ELPGALLILLTIERLGRRLPFAASNIVAGVSCLVTAFLPEGIPWLRTTVATLGRLGITMAFEIVY 449

  Fly   415 LYGGELFPTVVRSSGVGLCSMVGRIGSIVAP-LIVDLAAYGLWVAPLIFGIFSILAMLGTIFLPE 478
            |...||:||.:|:.||.|||.:...|.|:|| |:..|||..|.:..:||||.:.:.....:.|||
Mouse   450 LVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAIWLELPLIIFGILASVCGGLVMLLPE 514

  Fly   479 TRGTPLPETLEDGETF--------GRKKKDQ 501
            |:|..||||:||.|..        |||||.|
Mouse   515 TKGIALPETVEDVEKLGSSQLHQCGRKKKTQ 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_611451.1	MFS_SLC22	82..477	CDD:340875	142/415 (34%)
Slc22a3	NP_035525.1	2A0119	12..523	CDD:273328	168/518 (32%)
		Proline-rich sequence. /evidence=ECO:0000250|UniProtKB:O75751	284..288		3/3 (100%)