DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and Slc22a1

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_033228.2	Gene:	Slc22a1 / 20517	MGIID:	108111	Length:	556	Species:	Mus musculus

Alignment Length:	543	Identity:	157/543 - (28%)
Similarity:	257/543 - (47%)	Gaps:	73/543 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 TGDPIISQIGDFRRYQLFFFFIVLLCKFGTGWHTLGHIFLAAPTPLSCKTENVTD--------PC 76
            |.|.::..:|:|..:|...|.::.|.........:|.:||.......|::..|.:        |.
Mouse     3 TVDDVLEHVGEFGWFQKQAFLLLCLISASLAPIYVGIVFLGFTPDHHCRSPGVAELSQRCGWSPA 67

  Fly    77 SD------------------ECSETEFDTS-----------------------------VFQ--- 91
            .:                  :|.:.|.|.:                             |:.
Mouse    68 EELNYTVPGLGSAGEASFLSQCMKYEVDWNQSTLDCVDPLSSLAANRSHLPLSPCEHGWVYDTPG 132

  Fly    92 STIITEWNLTCESKQLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGLIVCVS 156
            |:|:||:||.|.......|.||.|.||...||::.|..|||:||:...|....:..::|::..|:
Mouse   133 SSIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLVTSLSGVLTAVA 197

  Fly   157 PYYWFYCLFRFLVAVATAGTMTTSFVLLMEIVGPKKREMVAILYQIPFNIGHASLALFAYFIREW 221
            |.|....|||.|..:.:.|:..:.:.|:.|.||...|...|||||:.|.:|...||..||.|.:|
Mouse   198 PDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTAILYQVAFTVGLVGLAGVAYAIPDW 262

  Fly   222 RWFQFSITIFSIVFVIYIWLVPESPRWLFTTGKLDKSIKILEKIAKCN-KAPTETIRP---EIEA 282
            ||.|.::::.:.:|::|.|.||||||||.:..:..::::|:|:||:.| |.|...::.   |.:|
Mouse   263 RWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTQAVRIMEQIAQKNRKVPPADLKMMCLEEDA 327

  Fly   283 AYGALAARQPVKKGTVVDLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAA 347
            :    ..|.|    :..||||||.:|..|:.:...|....::|.|...:|.|.|.|:::....::
Mouse   328 S----ERRSP----SFADLFRTPSLRKHTLILMYLWFSCAVLYQGLIMHVGATGANLYLDFFYSS 384

  Fly   348 GVGIPGTCLCALMTKYLGRKKTLLLSNGCSALGLILLACLSTQAEAVRVTCATIGLFGASITFPN 412
            .|..|...:..:....:||...:..||..:....:|:..:..:...:.||.|.:|..||:|....
Mouse   385 LVEFPAAFIILVTIDRIGRIYPIAASNLVAGAACLLMIFIPHELHWLNVTLACLGRMGATIVLQM 449

  Fly   413 VYLYGGELFPTVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVA-PLI-FGIFSILAMLGTIF 475
            |.|...||:||.:|:.|:.:||.:..:|.|..|.:| .....:|.| ||| ||:..:.|...|:.
Mouse   450 VCLVNAELYPTFIRNLGMMVCSALCDLGGIFTPFMV-FRLMEVWQALPLILFGVLGLSAGAVTLL 513

  Fly   476 LPETRGTPLPETLEDGETFGRKK 498
            ||||:|..||||:|:.|..||:|
Mouse   514 LPETKGVALPETIEEAENLGRRK 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	135/439 (31%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	127/427 (30%)
Slc22a1	NP_033228.2	2A0119	12..525	CDD:273328	148/521 (28%)
Slc22a1	NP_033228.2	MFS	125..515	CDD:119392	127/398 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920