DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and Slc22a8

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001158106.1	Gene:	Slc22a8 / 19879	MGIID:	1336187	Length:	537	Species:	Mus musculus

Alignment Length:	535	Identity:	159/535 - (29%)
Similarity:	247/535 - (46%)	Gaps:	76/535 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 TGDPIISQIGDFRRYQLFFFFIVLLCKFGTGWHTLGHIFLAAPTPLSCK---------------- 68
            |...|:.::|....:|.....::.|...|...|.|..||.|......|:
Mouse     2 TFSEILDRVGSMGPFQYLHVTLLALPILGIANHNLLQIFTATTPDHHCRPPPNASLEPWVLPLGP 66

  Fly    69 ---------------------TENVTDPCSDECSETEFDTSVFQS---TIITEWNLTCESKQLAS 109
                                 |:..|:||        .|..::.|   ||:|||:|.|.|.:|..
Mouse    67 NGKPEKCLRFVHLPNASLPNDTQGATEPC--------LDGWIYNSTRDTIVTEWDLVCGSNKLKE 123

  Fly   110 LSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQL-ITGLIVCVSPYYWFYCLFRFLVAVAT 173
            ::||:.|.|||.|..:||..:||:||:| .||..::.| .:|.....||....|.:||||...:.
Mouse   124 MAQSVFMAGILVGGPVFGELSDRFGRKP-ILTWSYLLLAASGSSAAFSPSLTVYMIFRFLCGCSI 187

  Fly   174 AGTMTTSFVLLMEIVGPKKREMVAILYQIPFNIGHASLALFAYFIREWRWFQFSITIFSIVFVIY 238
            :|...::.:|.:|.|....|.:.:......:.||...|...||.:.:|||.|.|::....:|.:.
Mouse   188 SGISLSTIILNVEWVPTSTRAISSTTIGYCYTIGQFILPGLAYAVPQWRWLQLSVSAAFFIFSLL 252

  Fly   239 IWLVPESPRWLFTTGKLDKSIKILEKIAKCNKAPTE-----------TIRPEIEAAYGALAARQP 292
            .|.||||.|||..:||..|::|.|:::|..|....|           .::.:|.:|        .
Mouse   253 SWWVPESIRWLVLSGKFSKALKTLQRVATFNGKKEEGEKLTVEELKFNLQKDITSA--------K 309

  Fly   293 VKKGTVVDLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAGVGIPGTCLC 357
            ||.| :.||||...:|..|..::..|......||..|..|...|.||:|...|..||.||...:.
Mouse   310 VKYG-LSDLFRVSILRRVTFCLSLAWFATGFAYYSLAMGVEEFGVNIYILQIIFGGVDIPAKFIT 373

  Fly   358 ALMTKYLGRKKT---LLLSNGCSALGLILLACLSTQAEAVRVTCATIGLFGASITFPNVYLYGGE 419
            .|...||||:.|   ||:..|.:.|.||.   :|::.:.:|...|..|....|.:|..::||..|
Mouse   374 ILSISYLGRRITQGFLLILAGVAILALIF---VSSEMQLLRTALAVFGKGCLSGSFSCLFLYTSE 435

  Fly   420 LFPTVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLGTIFLPETRGTPL 484
            |:|||:|.:|:|:.::..|:||::|||:........::..:|||..::|......||.||...||
Mouse   436 LYPTVLRQTGMGISNIWARVGSMIAPLVKITGELQPFIPNVIFGTMTLLGGSAAFFLLETLNRPL 500

  Fly   485 PETLEDGETFGRKKK 499
            |||:||.:.:.::.|
Mouse   501 PETIEDIQDWYQQTK 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	138/419 (33%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	131/407 (32%)
Slc22a8	NP_001158106.1	2A0119	11..503	CDD:273328	152/512 (30%)
Slc22a8	NP_001158106.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..537		1/3 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.050