DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and Slc22a25

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_620263.1	Gene:	Slc22a25 / 192273	RGDID:	621104	Length:	552	Species:	Rattus norvegicus

Alignment Length:	551	Identity:	144/551 - (26%)
Similarity:	246/551 - (44%)	Gaps:	93/551 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 IISQIGDFRRYQLFFFFIVLLCKFGTGWHTLGHIFLAA-PT------------------------ 63
            :::|:|...|:|:.....:|:.......|:|...|.|. |.
  Rat     6 LLNQVGSLGRFQILQMTFILIFNIIISPHSLLENFTAVIPNHRCWVPILDNDTVSGNDNGNLSQD 70

  Fly    64 --------------PLSCK-------------------TENVTDPCSDECSETEFDTSVFQSTII 95
                          |..|:                   ||..|:||.|   ...:|.|.|.||||
  Rat    71 DLLRVSIPLDSDLRPEKCRRFVQPQWDLLHLNGTFSSVTEPDTEPCVD---GWVYDQSTFLSTII 132

  Fly    96 TEWNLTCESKQLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQL-ITGLIVCVSPYY 159
            |||:|.|||:.|.|:::.:.:.|||.|:||:|...||:||| ..|.|..:|: :|......:|.:
  Rat   133 TEWDLVCESQSLDSIAKFLFLTGILVGNILYGPLTDRFGRR-LILICASLQMAVTETCAAFAPTF 196

  Fly   160 WFYCLFRFLVAVATAGTMTTSFVLLMEIVGPKKREMVAILYQIPFNIGHASLALFAYFIREWRWF 224
            ..||..|||..::.:..:|.|.:|::|...||.:.:...|......||...||..|:.:|.|...
  Rat   197 LIYCSLRFLAGISFSTVLTNSALLIIEWTRPKFQALATGLLLCAGAIGQTVLAGLAFTVRNWHHL 261

  Fly   225 QFSITIFSIVFVIYIWLVP-----ESPRWLFTTGKLDKSIKILEKIAKCNKAPTET--------- 275
            ..::::     .|:..|||     ||.|||..|.||.|.:|.|.|:|..|.....|
  Rat   262 HLAMSV-----PIFFLLVPTRWLSESARWLIMTNKLQKGLKELIKVAHINGMKNSTDVLTIEVVR 321

  Fly   276 --IRPEIEAAYGALAARQPVKKGTVVDLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGN 338
              ::.|:||:.         .|.::.||||||.:|.:...::....||.:...|.......|..|
  Rat   322 TIMKEELEASQ---------TKSSLWDLFRTPNLRKRICLLSLVRFVVWLSVIGLLINFQHLRIN 377

  Fly   339 IFISNAIAAGVGIPGTCLCALMTKYLGRKKTLLLSNGCSALGLILLACLSTQAEAVRVTCATIGL 403
            :|:...:...:.||...:...:..:|||:.:.|.......:.::.:..:..:.:.:|:..||.|.
  Rat   378 VFLLQCLLGIITIPANLVGIFLVNHLGRRISQLFIISLFGISILAIIFVPQEMQILRMVLATFGG 442

  Fly   404 FGASITFPNVYLYGGELFPTVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSIL 468
            ..:.::..:..::..||.||::|::.:|:..:.|..|:.::||.:.|..|...:..:|:|:.|.|
  Rat   443 VFSFVSVSSALVHANELLPTIIRATALGVIGIAGSTGAALSPLFMILRTYSDSLPWIIYGVLSFL 507

  Fly   469 AMLGTIFLPETRGTPLPETLEDGETFGRKKK 499
            ..|..:.||||:..|||::::|.|..||..:
  Rat   508 GGLVVLLLPETKNQPLPDSIQDVENEGRASR 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	122/418 (29%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	114/406 (28%)
Slc22a25	NP_620263.1	2A0119	11..525	CDD:273328	138/531 (26%)
		Aldolase_II	39..>85	CDD:294146	3/45 (7%)
		MFS	125..506	CDD:119392	111/395 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D464838at2759
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020