DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and Y66D12A.13

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_499489.1	Gene:	Y66D12A.13 / 190497	WormBaseID:	WBGene00013439	Length:	533	Species:	Caenorhabditis elegans

Alignment Length:	534	Identity:	130/534 - (24%)
Similarity:	218/534 - (40%)	Gaps:	84/534 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 ISQIGDFRRYQL----FFFFIVLLCKFGTGWHTLGHIFLAAPTPLSCK--TENVTDP-------- 75
            :..|.:...|||    |..|::........::..|   .|||....|.  ..|.|.|
Worm     6 VDDIFELDAYQLVVLAFNEFLIFTMLSNVVFNMFG---AAAPRLPGCDDIIYNATSPFQQCEQYD 67

  Fly    76 ----CSDECSETEFDTSVFQSTIITEWNLTCESKQLASLSQSIV----------------MLGIL 120
                |.:...|.||      .::..|:...|......|...||.                |:||:
Worm    68 AHLDCEEPAMEYEF------KSVAVEFQELCSRHNEHSYMDSITQLFGVNNRVRFSTTSQMIGIM 126

  Fly   121 FGSILFGMFADRYGRRPAFLTCCFMQLITGLIVCVSPYYWFYCLFRFLVAVATAGTMTTSFVLLM 185
            .||.:.|..:|.|||:...|....|.|........|.....:.:.||.:.:...|..|...:|::
Worm   127 LGSAIAGQLSDLYGRKKITLLFLCMMLFFSTSSSFSSSIEVFIIVRFFIGICCGGLTTVGSILVV 191

  Fly   186 EIVGPKKREMVAILYQIPFNIGHASLALFAYFIREWRWFQFSITIFSIV-FVIYIWLVPESPRWL 249
            |.:....|..::.:  :.:...:...|||||...|||.........::: .:|..:|:||||::|
Worm   192 ENLPSAHRLWMSTV--VTWAPNYMLFALFAYITGEWRCLARMCNAMTVIAILICAFLLPESPKYL 254

  Fly   250 FTT--GKLD-KSIKILEKIAKCNKAPTETIRPEIE-AAYGAL----AARQPVKKGTVVDLFRTPY 306
            ...  |||. ||||.:.|..:.....|:|   ||| ..:.|:    .:|...||.:.:.|:..|.
Worm   255 IQARKGKLAVKSIKYINKFKRVRNQLTDT---EIEDVVHSAIEVDTKSRAKAKKYSFIHLYIHPK 316

  Fly   307 MRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAG-----VGIPGTCLCALMTKYLGR 366
            :.::|:..:.:...|..|.||.......|.|:|:: ||..:|     ||.....|.....:::||
Worm   317 ITVQTVVASISMFSVSYVTYGLLFNYDVLTGSIYM-NAAVSGFLRYVVGAVVAVLDHFGGEHVGR 380

  Fly   367 KKTLLLSNG---CSALGLILL----ACLSTQAEAVRVTCATIGLFGASITFPNVYLYGGELFPTV 424
            |:...::..   |...|:..:    ..|..::....:|....|..|.  .|..:.|...|:|||.
Worm   381 KRMHFITVSFIMCCMFGIFFIYFNDLVLEYKSWIRALTLLAFGTTGC--LFLQLLLITAEMFPTG 443

  Fly   425 VRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVAP---LIFGIFSIL-AMLGTIFLPETRGTPLP 485
            :|:......::.||:|::..|::.   :|.|..|.   ||.|:..:| .::..||:|||:..|||
Worm   444 IRNIASAHINVCGRLGNVFGPMVF---SYKLGFAGSGYLILGVICLLDVIVFHIFIPETKNQPLP 505

  Fly   486 ETLEDGETFGRKKK 499
            :.:.     .|||:
Worm   506 QGMP-----SRKKQ 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	110/442 (25%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	103/430 (24%)
Y66D12A.13	NP_499489.1	2A0119	36..506	CDD:273328	120/489 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48025
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.980