DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and Y57G11C.23

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_502801.2	Gene:	Y57G11C.23 / 190377	WormBaseID:	WBGene00013318	Length:	529	Species:	Caenorhabditis elegans

Alignment Length:	507	Identity:	138/507 - (27%)
Similarity:	210/507 - (41%)	Gaps:	101/507 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 IGDFRRYQLFFFFIVLLCKFGTGWHTLGHIFLAAPTPLSCKTEN-----VTDPC---------SD 78
            ||....||:..||.|.:         |..|||.......| ||:     :.:.|         ||
Worm    12 IGLMILYQMTLFFSVQM---------LFVIFLEYMPKTHC-TEDRYCYKLKNKCMSDFDRHSDSD 66

  Fly    79 EC--SETEFDTSV-------FQSTIITEWNLTCESKQLASLSQSIVMLGILFGSILFGMFADRYG 134
            .|  :.|.||..|       |.|... |:...|...:..|.|.| ..||.|.|:::.|..:|..|
Worm    67 VCPFASTNFDQCVVAANKTDFYSAQY-EYQQDCTGLKYFSSSTS-TFLGTLVGNLILGYLSDTIG 129

  Fly   135 RRPAFLTCCFMQLITG-----LIVCVSPYYWFYCLFRFLVAVATAGTMTTSFVLLMEIVGPKKRE 194
            |||.::    ..::.|     |...::....|| :|||||..|.|||:|..:....|:|.|.:|.
Worm   130 RRPVYI----FSILLGVPSVILSAALNDVMSFY-IFRFLVGFAIAGTLTVGWTYASEMVIPSRRF 189

  Fly   195 MVAILYQIPFNIGHASLAL--FAYFIREWRWFQFSITIFSIVFVIYIWLVPESPRWLFTTGKLDK 257
            .   |...| |..:|.:..  .::...|||...:.....|...:..||.:||||.:|....|..:
Worm   190 R---LRTFP-NWANARMMQVGVSWLAGEWRLASYLCAALSATVLPMIWYLPESPVFLEQKKKYKR 250

  Fly   258 SIKILEKIAK-CNKAPTETIRPEIEAAYGALAARQPVKKGTVVDLFRTPYMRIKTIFMANNWLVV 321
            :.:..||||. |          ::|....|....|.:||.|.:.|.::|.:|       .|:||:
Worm   251 AERSREKIAGIC----------QLEYEPKAREEMQDLKKITPIKLLKSPVLR-------TNFLVL 298

  Fly   322 CMV--YYGTAQYVSALGGNIFISNAIAAGVGIPGTCLCALM--------------TKYLGRKKTL 370
            |.:  |.|.:.|::.|.......|...      |..||.|:              ..:|||:...
Worm   299 CWMWFYVGMSVYITDLNSGDMAENFYV------GQFLCGLVLTVSKIMIGILEPKIPWLGRRCLF 357

  Fly   371 LLSNGCSALGLI-LLACLSTQAE-AVRVTCATIGLF-GASITFPNVYLYGGELFPTVVRSSGVGL 432
            :.|...:.|..| :|..|.|:.: :...|.|.|..: |.|:.....||...||.||.||:....|
Worm   358 ISSQIIAILAYITILTALWTRNKVSWWYTVAYILAYAGQSLCLETCYLSLAELMPTDVRTISGAL 422

  Fly   433 CSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLGTI----FLPETR 480
            .:::.:||:|:|.....:.   .|..||:|.|.:|:...|.|    :|||::
Worm   423 MNILMKIGTILASTTKPIK---FWYEPLLFIINTIICTGGLIIVWKYLPESK 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	119/434 (27%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	114/427 (27%)
Y57G11C.23	NP_502801.2	2A0119	<107..473	CDD:273328	111/401 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.870