DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and F32H5.4

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001370023.1	Gene:	F32H5.4 / 185216	WormBaseID:	WBGene00009350	Length:	528	Species:	Caenorhabditis elegans

Alignment Length:	529	Identity:	138/529 - (26%)
Similarity:	224/529 - (42%)	Gaps:	72/529 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PKAPKPLKPVTKTGDPIISQIGDFRRY-QLFFFFIVLLCKFGTGWHTLGHIFLAA-PTPLSCKTE 70
            ||..|.|....|.|           :| .|..||...:...|.| :||..::..| |..:||:..
Worm    22 PKEEKTLDNFMKLG-----------KYCWLILFFSEFMLLSGAG-NTLYMMYAGAYPKLVSCEGP 74

  Fly    71 NVTDPCSDECSETEFD---------TSVFQ-STIITEWNLTCESKQLASLSQSIVMLGILFGSIL 125
            :|.  ..|.| ::.||         ||.:. .:|..::...|........|.|:.|:|:|.||:.
Worm    75 DVF--IKDIC-KSSFDFHNPPNCTITSKYDFYSINVDYGHFCGEGAWVKTSISVQMVGVLIGSVT 136

  Fly   126 FGMFADRYGRRPAFLTCCFMQLITGLIVCVSPYYWFYCLFRFLVAVATAGTMTTSFVLLMEIVGP 190
            .|..||||||......|.||.....::...:....::.:.|.::::...|.::|..|..||.|..
Worm   137 SGAVADRYGRLKVLSVCFFMVSSLSILNTFAKDLIYFTIIRTILSIFKGGLLSTYGVYKMEHVPR 201

  Fly   191 KKREMVAILYQIPFNIGHASLALFAYFIREWRWFQFSITIFSIVFVIYIWLVPESPRWLFTTGKL 255
            :.|..:|.:  |.:...:..|:..||...:|..:|::|...|:...:....|.||||||...|::
Worm   202 QHRFWIATM--ISWAPNYMILSFVAYLCHDWITYQYAIFALSMPGAVVFLFVKESPRWLIQAGRI 264

  Fly   256 DKSIKILEKIAKCNKAPTETIRPEIEAAYGALAARQP--VKKGTVVD---LFRTPYMRIKTIFMA 315
            :::.::|:.|.:.:...::....|||........||.  :||....|   ||...||...|:.:.
Worm   265 EEARQVLKHIMEVDGNTSDHSWNEIEEMLQTEKKRQEERIKKRKNYDFRHLFWNKYMASVTMILW 329

  Fly   316 NNWLVVCMVYYGTAQYVSALGGNIFISNAIAAG---------VGIPGTCLCALMTKYLGRKKTLL 371
            ..........||....:..|.|:::| ||:..|         .|     |..|....||||...|
Worm   330 LGMFSTSFTNYGFVFNIEKLSGSLYI-NALLMGSLRWVLNIFFG-----LADLKFAKLGRKHIHL 388

  Fly   372 LSNGCSALGLILLACLST----------QAEAVRVTCATIGLFGASITFPNVYLYGG----ELFP 422
            :|.      |.:..|:.:          :..::.:..||:   .||.|...|::...    |.:|
Worm   389 ISK------LTITICVFSIFVTYYFEYEEDYSLIIRVATL---LASATASQVFITKSMVLMEFYP 444

  Fly   423 TVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLGTIFLPETRGTPLPET 487
            ||:|:|.|...|...|||:|:.|.:..|..|......::.|.....|:...:.||||:|.|||||
Worm   445 TVIRNSAVSFKSSASRIGTILGPQLFILCPYKSLPYAILTGFCLFDAIAFQLRLPETKGKPLPET 509

  Fly   488 LEDGETFGR 496
            :.:....||
Worm   510 MPERHKNGR 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	113/439 (26%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	103/418 (25%)
F32H5.4	NP_001370023.1	2A0119	<104..509	CDD:273328	109/421 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.970