DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and Slc22a6

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_032792.2	Gene:	Slc22a6 / 18399	MGIID:	892001	Length:	545	Species:	Mus musculus

Alignment Length:	521	Identity:	151/521 - (28%)
Similarity:	246/521 - (47%)	Gaps:	46/521 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 IISQIGDFRRYQLFFFFIVLLCKFGTGWH-TLGHIFLAAPT------------------------ 63
            ::.|:|...|:||....:|:........| ||.:...|.|.
Mouse     6 LLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIPAHHCRPPANANLSKDGGLEAWLPLD 70

  Fly    64 ----PLSC--------KTE----NVTDPCSDECSETEFDTSVFQSTIITEWNLTCESKQLASLSQ 112
                |.||        .||    .||:||.|   ...:|.|.|.|||:|||||.|..:....|:|
Mouse    71 KQGRPESCLRFPFPHNGTEANGTGVTEPCLD---GWVYDNSTFPSTIVTEWNLVCSHRAFRQLAQ 132

  Fly   113 SIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGLIVCVSPYYWFYCLFRFLVAVATAGTM 177
            |:.|:|:|.|:::||..|||.|||...:.......::|.....:|.|..||:||.|..::.|...
Mouse   133 SLFMVGVLLGAMMFGYLADRLGRRKVLILNYLQTAVSGTCAAYAPNYTVYCIFRLLSGMSLASIA 197

  Fly   178 TTSFVLLMEIVGPKKREMVAILYQIPFNIGHASLALFAYFIREWRWFQFSITIFSIVFVIYIWLV 242
            .....|.||.:....|..|..|....:::|...||..||.:..||..|.::::...|..||.|..
Mouse   198 INCMTLNMEWMPIHTRAYVGTLIGYVYSLGQFLLAGIAYAVPHWRHLQLAVSVPFFVAFIYSWFF 262

  Fly   243 PESPRWLFTTGKLDKSIKILEKIAKCNKAPTETIRPEIEAAYGALAARQPVKKG--TVVDLFRTP 305
            .||.||..::|:||.:::.|:::|:.|....|..:..||....:|.....:.||  :.::|.|.|
Mouse   263 IESARWYSSSGRLDLTLRALQRVARINGKQEEGAKLSIEVLQTSLQKELTLNKGQASAMELLRCP 327

  Fly   306 YMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAGVGIPGTCLCALMTKYLGRKKTL 370
            .:|...:.::..|......|||....:...|.::::...|...|.:|...:|.|:...:||:...
Mouse   328 TLRRLFLCLSMLWFATSFAYYGLVMDLQGFGVSMYLIQVIFGAVDLPAKFVCFLVINSMGRRPAQ 392

  Fly   371 LLSNGCSALGLILLACLSTQAEAVRVTCATIGLFGASITFPNVYLYGGELFPTVVRSSGVGLCSM 435
            |.|...:.:.:::...:......:|.:.|.:|....:.:|..::||.|||:||::|.:|:|:.|.
Mouse   393 LASLLLAGICILVNGIIPRGHTIIRTSLAVLGKGCLASSFNCIFLYTGELYPTMIRQTGLGMGST 457

  Fly   436 VGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLGTIFLPETRGTPLPETLEDGETFGRKKKD 500
            :.|:||||:|||...|.:...:...|||...:.|...|..||||.|.|||:|::|.::..|.|:.
Mouse   458 MARVGSIVSPLISMTAEFYPSIPLFIFGAVPVAASAVTALLPETLGQPLPDTVQDLKSRSRGKQK 522

  Fly   501 Q 501
            |
Mouse   523 Q 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	125/403 (31%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	116/391 (30%)
Slc22a6	NP_032792.2	2A0119	11..509	CDD:273328	145/500 (29%)
		MFS	129..499	CDD:119392	105/369 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..545		3/9 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.050