DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and C46C2.2

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_501604.2	Gene:	C46C2.2 / 177744	WormBaseID:	WBGene00008110	Length:	520	Species:	Caenorhabditis elegans

Alignment Length:	473	Identity:	108/473 - (22%)
Similarity:	189/473 - (39%)	Gaps:	86/473 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 NVTDPCSDECSETEFDTSVFQSTIITEWNLTCESKQLASLSQSIVMLGILFGSILFGMFADRYGR 135
            |:|.....:| .||...|.:.|..: |:.:.|...........:..:|:|.|:|:.|..||:.||
Worm    73 NLTGTALSDC-HTEKSHSYYSSAAM-EFEIYCRPGWKDFRPAFVQYVGVLIGNIILGYVADQIGR 135

  Fly   136 RPAFLTCCFMQL----ITGLIVCVSPYYWFYCLFRFLVAVATAGTMTTSFVLLMEIVGPKKREMV 196
            :..|:....:.:    ::.....::.:|    :||.|..:..||||...:....|:|.|.:|
Worm   136 KKTFILSMLIGIPSLSLSATFNSIAAFY----IFRALTGIGIAGTMIVGWAYFSELVSPHQR--- 193

  Fly   197 AILYQIPFNI--------GHASLALFAYFIREWRWFQFSITIFSIV-FVIYIWLVPESPRWLFTT 252
                   |.:        ....|.|.|.|..|||.......:.|:: ..|..:::|||..||...
Worm   194 -------FKLRTFSNWANARIMLTLVALFTGEWRLSSHVSAVISLITLAIVYFILPESHIWLRKK 251

  Fly   253 GKLDKSIKILEKIAKCNKAPTETIRPEIEAAYGALAARQPVKKGTVVDLFRTPYMRIKTIFMANN 317
            |:.:::....::||.........:.|..:||...    :|.|...:..:|..|.:|...:.:...
Worm   252 GRYEEAEVSRKRIADLAGIEFVPMPPPEKAADNV----EPEKAVNICTVFADPQLRKNILILWLM 312

  Fly   318 WLVVCMVYYGTAQYVSALGGNI--------FISNAIAAGVGIPGTCLCALMTKYL---GRKKTLL 371
            |.|..|    ||......||::        |:|..:.:.|.|    :......||   ||:..||
Worm   313 WFVTGM----TAYLTDLCGGDMTKNFWVGQFLSGILLSVVRI----IMGFADGYLPWMGRRFVLL 369

  Fly   372 LSNGCSALGLILLACLSTQAEAVRVTCATIG---------LFGASITFPNV-----YLYGGELFP 422
            .|   .:|.::...|:        :.....|         ::.||..|.::     ||...||.|
Worm   370 CS---QSLAIVFFGCV--------IAFLFAGEKGQWYYTAVYLASFVFTSIVWEPCYLCASELMP 423

  Fly   423 TVVRSSGVGLCSMVGRIGSIVAPLIVDLAAY---GLWVAPLIFGIFSILAMLGTIFLPETRGTPL 484
            |.||::....||:|||..:|.|.::..|...   |:.:..:..|:.:::|  ...||.||:..
Worm   424 TDVRATSTASCSIVGRFANIGASMLSGLKTVYEPGVHMISISLGLTNVVA--AYFFLQETKNC-- 484

  Fly   485 PETLEDGETFGRKKKDQA 502
              :|:...|...|..::|
Worm   485 --SLDKAGTSAAKPAEKA 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	99/442 (22%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	96/430 (22%)
C46C2.2	NP_501604.2	2A0119	58..486	CDD:273328	104/457 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48025
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920