DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and B0252.3

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001021888.1	Gene:	B0252.3 / 174130	WormBaseID:	WBGene00015088	Length:	484	Species:	Caenorhabditis elegans

Alignment Length:	497	Identity:	129/497 - (25%)
Similarity:	226/497 - (45%)	Gaps:	69/497 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 TGDPIISQIGDFRRYQLFFFFIVLLCKFGTGWHTLGHIFLAAPTPLSCKTENVTDPCSDECSETE 84
            :.|.:::.:....|:.|   ..:|:|  |..|..|....| .|:.:...:||
Worm    28 SADDVLNTLDKSNRHIL---TCILVC--GLAWSPLAFTGL-CPSFVVKASEN------------- 73

  Fly    85 FDTSVFQSTIITEWNLTCESKQLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLIT 149
               |.|.. :..|::||.::..||..:.:..|:|.:.|.:.....||.|||.|.|:....:..:.
Worm    74 ---SSFIG-VADEFDLTGDASWLAESTTTFYMVGNMIGGMFIPPLADHYGRLPVFVATVLLMAVG 134

  Fly   150 GLIVCVSPYYWFYCLFRFLVAVATAGTMTTSFVLLMEIVGPKKREMVAILYQIPFNIGHASLALF 214
            |:|...|.....:|:.|.:..:.........:||..|....:.|...::.:.:.:.:|...|.|.
Worm   135 GMISAFSTSIMMFCIMRMIHGIFYTAAGLAGWVLGYENTPLRLRFFTSVYFGVMWVVGACFLGLL 199

  Fly   215 AYFIREWRWFQFSITIFSIVFVIYIWL-VPESPRWLFTTGKLDKSIKILEKIAKCNKAPTETI-- 276
            ||.:.:||:..|.|::.:|...:.|:: ||||..:|.::.:.:|....||||    :.|...|
Worm   200 AYILPDWRYLMFCISVPNIFVALLIYMTVPESLHFLVSSQQNEKIEAWLEKI----RGPKGDISA 260

  Fly   277 ------RPEIEAAYGALAARQPVKKGTVVDLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSAL 335
                  |.|..:::..|.......|..:|      |:.:.|..    |:|...:|:|.|.|.:.|
Worm   261 SDIVEDRDENGSSFKTLCREMWKHKMFIV------YVLVMTYI----WIVDTFIYFGLAFYSTNL 315

  Fly   336 GGNIFISNAIAAGVGIPGTCLCAL-MTKYLGRKKTLLLSN-----GCSALGLILLACLSTQAEAV 394
            .||::::..:.:.|..|......: |.|| |||  :|:|.     |.|.||::|      .:||.
Worm   316 AGNLYLNFVLMSLVEAPAYIFSPIFMNKY-GRK--VLISGTHIIAGLSFLGIVL------SSEAW 371

  Fly   395 RVTCATIGLFGASITFPNVYLYGGELFPTVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVAP 459
            .:....:|.|..|.:|.::|::..|:|||..|:..:|.|..:.|.|.:::|.:..|.|... :||
Worm   372 HIHFWLLGKFAISCSFMSIYMFASEIFPTDGRNKCIGFCETLSRFGGMLSPYLSHLTAVHA-LAP 435

  Fly   460 LIFGIFSILAMLG---TIFLPETRGTPLPETLEDGETFGRKK 498
            .|  ..|::|:.|   |:.||||..|.||.|:  .||..|::
Worm   436 AI--TLSLIAVSGGLLTLILPETLNTKLPSTI--AETASRRQ 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	113/419 (27%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	106/407 (26%)
B0252.3	NP_001021888.1	MFS	87..454	CDD:119392	101/392 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48025
OrthoDB	1	1.010	-	-		D464838at2759
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.030