DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and K05F1.6

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001342018.1	Gene:	K05F1.6 / 173977	WormBaseID:	WBGene00019408	Length:	858	Species:	Caenorhabditis elegans

Alignment Length:	586	Identity:	156/586 - (26%)
Similarity:	257/586 - (43%)	Gaps:	108/586 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 QDPKAPKPLKPVTKTGDPIISQIGDFRRYQLFFFFIVLLCKFGTGWHTLGHIFLAAPTPLSCKT- 69
            ::.|..||..|:...|  |::.||..|.:|::.:.::.|.:.......|..:::.......|..
Worm   189 KERKEGKPTDPIDFEG--ILNIIGGCRWWQIWIYVLIALQQIPHAMFNLNVVYMMYDPEFQCMVP 251

  Fly    70 -----------------------ENVT--------------DPC-----SDE------------- 79
                                   :|::              |.|     |:|
Worm   252 GFNDTNDTTISSHGPYLWGVDDIKNISFVFPNANSDGAYQRDSCYFYERSEERYRQLRRMPLETA 316

  Fly    80 -------------CSETEFDTSVFQSTIITEWNLTCESKQLASLSQSIVMLGILFGSILFGMFAD 131
                         |....|:..|...||:|::||.|:|......:.....:|.|.|.:|.|:.:|
Worm   317 MSEAWKDVAPKKKCQAYHFEKDVMVETIVTDFNLVCDSWFAKGHAHMFYSIGYLLGCVLGGIASD 381

  Fly   132 RYGRRPAFLTCCFMQLITGLIVCVSPYYWFYCLFRFLVAVATAGTMTTSFVLLMEIVGPKKREMV 196
            :.||:|..:....:..:.|:.:..:.||..:.|.|.|.|:........::.|.|||.|.|.|.||
Worm   382 KIGRKPTIIGFGILSSMLGVFLPFNDYYPMFLLIRLLSAICNEAADLAAYTLCMEITGTKYRAMV 446

  Fly   197 AILYQIPFNIGHASLALFAYFIREWRWFQFSITIFSIVFVIYIWLVPESPRWLFTTGKLDKSIKI 261
            ..:.|.|:.:|:|.|||.||..:.|:..|........:.:|:|..:|||||||....::.::.::
Worm   447 GSMLQAPWALGYALLALIAYLTKSWKTIQVIAAGLHFMSIIFICSIPESPRWLMVQNRVSEAEEV 511

  Fly   262 LEK-------------IAKCNKAPTETIRPEIEAAYGALAARQPVKK--GTV--VDLFRTPYMRI 309
            :.|             .:||...|:     ::|..  :...|:..||  |.:  :|||....:|.
Worm   512 IRKACREPPFPFNMCTTSKCGNLPS-----DLELV--SHRERKLNKKNGGKIGFLDLFTMKELRY 569

  Fly   310 KTIFMANNWLVVCMVYYGTAQYV---SALGGNIF-----ISNAIAAGVGIPGTCLCALMTKYLGR 366
            :||.:...::...:||||....:   ||.|..:|     ::|.||..:.||....|..|.: |||
Worm   570 RTISVCIVFMATALVYYGLVMALSDQSAPGRTLFTGYFHLNNGIAGAIEIPTLFACVWMMQ-LGR 633

  Fly   367 KKTLLLSNGCSALGLILLACLSTQAEAVRVTCATI--GLFGASITFPNVYLYGGELFPTVVRSSG 429
            ||.|:|:...|.| .|::|.||..:....:..|.:  |.......|..:|::..||:|||||::.
Worm   634 KKALMLTLITSGL-FIIVAMLSMVSGHYMLALAFMYFGKIAVQGAFNILYIFTSELYPTVVRNTA 697

  Fly   430 VGLCSMVGRIGSIVAPLIVDLAAYGLWVAP-LIFGIFSILAMLGTIFLPETRGTPLPETLEDGET 493
            ||:.|||.|.||.::..|..|:...|.:.| :||.:||:.|.:....||||...||||||:|...
Worm   698 VGVTSMVARFGSGLSSYIALLSNISLPIVPMIIFAVFSLFAGMLVFVLPETSEKPLPETLDDAIN 762

  Fly   494 F 494
            |
Worm   763 F 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	132/429 (31%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	124/417 (30%)
K05F1.6	NP_001342018.1	MFS_SLC22	333..746	CDD:340875	125/421 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920