Protein Alignment CG8654 and SLC22A12

DIOPT Version :9

• Sequence 1: NP_001246441.1
• Gene: CG8654 / 37275
• FlyBaseID: FBgn0034479
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: XP_006718493.1
• Gene: SLC22A12 / 116085
• HGNCID: 17989
• Length: 578
• Species: Homo sapiens
• Alignment Length: 465
• Identity: 153/465 - (32%)
• Similarity: 232/465 - (49%)
• Gaps: 46/465 - (9%)

  Fly    69 TENVTDPCSDECSETEFDTSVFQSTIITEWNLTCESKQLASLSQSIVMLGILFGSILFGMFADRY 133
            :|..|:||.|   ...:|.|:|.|||:.:|||.|:|..|..::|||.:.|||.|:...|..:||:
Human   109 SEADTEPCVD---GWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRF 170

  Fly   134 GRRPAFLTCCFMQL-ITGLIVCVSPYYWFYCLFRFLVAVATAGTMTTSFVL-------------- 183
            ||| ..||..::|: :.|.....:|.:..|||||||:|.|.||.|..:..|
Human   171 GRR-LVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLRRSLTWRHAGGLHA 234

  Fly   184 -----------LMEIVGPKKREMVAILYQIPFNIGHASLALFAYFIREWRWFQFSITIFSIVFVI 237
                       :||....:.|.:|..|..:.|:.||...|..||.:|:|...|..:::...:..:
Human   235 GSRAEPLGLLAVMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFL 299

  Fly   238 YIWLVPESPRWLFTTGKLDKSIKILEKIAKCN--KAPTETIRPEI-------EAAYGALAARQPV 293
            |.|.:.||.|||.|||:||..::.|.::|..|  .|..:|:.||:       |.:.|    :.|.
Human   300 YSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMG----QPPA 360

  Fly   294 KKGTVVDLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAGVGIPGTCLCA 358
            ..||   |.|.|.:|.:|......|......::|.|..:.|||.|||:.......|.||......
Human   361 SLGT---LLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGAL 422

  Fly   359 LMTKYLGRKKTLLLSNGCSALGLILLACLSTQAEAVRVTCATIGLFGASITFPNVYLYGGELFPT 423
            |:..:|||:.||..|...:.|.::....:..:..|:|...|.:||.|....|..:.:|..|||||
Human   423 LLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPT 487

  Fly   424 VVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLGTIFLPETRGTPLPETL 488
            |:|.:.|||..|..|.|:|:.||:..|..:|.|:..|::|...:|:.|..:.||||:..|||:|:
Human   488 VLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTI 552

  Fly   489 EDGETFGRKK 498
            :|.:....||
Human   553 QDVQNQAVKK 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	144/436 (33%)
		MFS	87..477	CDD:119392	136/424 (32%)
SLC22A12	XP_006718493.1	2A0119	11..551	CDD:273328	149/452 (33%)
		MFS	122..541	CDD:119392	137/426 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.96023	Normalized mean entropy	S4609
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	7.000