DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and Slc22a13

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_598741.2	Gene:	Slc22a13 / 102570	MGIID:	2143107	Length:	551	Species:	Mus musculus

Alignment Length:	515	Identity:	152/515 - (29%)
Similarity:	248/515 - (48%)	Gaps:	52/515 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 IISQIGDFRRYQLFFFFIVLLCKFGTGWHTLGHIFL----------------------------- 59
            :::::|||.|:|:....::.:..|...:...|.:|:
Mouse     7 VMAEVGDFGRFQVRLTILMGIPNFLAAFFIFGQVFMVLDEAHHCSVSWVKNHTFNLSAAEQLAIS 71

  Fly    60 ----AAPTPLSC-------KTENVTDPCSDECSETEFDTSVFQ------STIITEWNLTCESKQL 107
                .|..|.||       .:.::.|..|...:||:...|.:.      .::..|::|.|:.|.|
Mouse    72 IPNDTAGRPESCLMFRPPPDSASLEDILSHRFNETQACDSGWDYPENRPQSLKKEFDLVCDRKNL 136

  Fly   108 ASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGLIVCVSPYYWFYCLFRFLVAVA 172
            ...|||:.|.|:|.|:::||...|..||||:.|....:..||.:.......:..|...||::|.|
Mouse   137 KKTSQSVFMAGLLVGALVFGPVCDWIGRRPSLLMQVLLSGITSMATAFVSSFELYLALRFVLATA 201

  Fly   173 TAGTMTTSFVLLMEIVGPKKREMVAILYQIPFNIGHASLALFAYFIREWRWFQFSITIFSIVFVI 237
            .||.:.::.||:.|.|||..|....:|.|....:|...||..||.:|.||..|.:.|...::...
Mouse   202 NAGFLLSTNVLISEWVGPSWRTQAVVLAQSNVALGQMVLAGLAYGVRNWRLLQITGTAPVLLLFF 266

  Fly   238 YIWLVPESPRWLFTTGKLDKSIKILEKIAKCNKAPTETIRPEIEAAYGALAARQPVKKGTVVDLF 302
            |.|::|||||||.:.|:.:::.::::|.|..|..|   :.||:   ...|...:....|..:|||
Mouse   267 YFWVLPESPRWLLSQGRTEEAKQLVQKAALVNGRP---LSPEL---LNQLVPEKTGPSGNALDLF 325

  Fly   303 RTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAGVGIPGTCLCALMTKYLGRK 367
            |.|::|..|:.:...|.|..:|||..:..|...|.:|:::..|...|.:||..|..||.:.||||
Mouse   326 RHPHLRKVTLILIAVWFVDSLVYYSLSFQVGDFGLDIYVTQLIFGAVEMPGRFLSVLMMEKLGRK 390

  Fly   368 KTLLLSNGCSALGLILLACLSTQAEAVRVTCATIGLFGASITFPNVYLYGGELFPTVVRSSGVGL 432
            .:.|.:...:.:..|::..:......|....|.:|.|.::..|...|:|..|||||::|.:|:||
Mouse   391 WSQLCTLTLAGIMYIIIIFIPGDLPTVVTVLAVVGKFASAAAFTISYVYTAELFPTIIRQTGMGL 455

  Fly   433 CSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLGTIFLPETRGTPLPETLEDGE 492
            .|:..|:|.|:.||::.|..|...:..:|||...|.|.|....||||||..|.:||:|.|
Mouse   456 VSIFSRVGGIITPLVMLLEQYHQAIPMVIFGSLPIGAGLLCALLPETRGQTLKDTLQDLE 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	132/407 (32%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	125/395 (32%)
Slc22a13	NP_598741.2	2A0119	12..510	CDD:273328	148/503 (29%)
Slc22a13	NP_598741.2	MFS	139..500	CDD:119392	119/366 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.910