DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and slc22a13

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	XP_031760340.1	Gene:	slc22a13 / 100491580	XenbaseID:	XB-GENE-959647	Length:	547	Species:	Xenopus tropicalis

Alignment Length:	530	Identity:	164/530 - (30%)
Similarity:	247/530 - (46%)	Gaps:	83/530 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 IISQIGDFRRYQLFFFFIVLLCKFGTGWHTLGHIFLAAPTPLSCKTE------------------ 70
            |:..:|:|.|:|.....::.|..|...:|....:|:..|.|..|.:.
Frog     7 ILKNVGEFGRFQKQLVVVLSLLSFLNAFHMFSQVFMEIPVPHRCDSRWILLINPNLTEAERLNYT 71

  Fly    71 ------------------------------NVTDPCSDECSETEFDTSVFQSTIITEWNLTCESK 105
                                          |.|.||.|   ..|:|||..:||::|:::|.|..:
Frog    72 IPRDGRGQYEQCLMYSPVQWDMESIEKFGLNSTGPCQD---GWEYDTSEQKSTLVTQFDLVCHRR 133

  Fly   106 QLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGLIVCVSPYYWFYCLFRFLVA 170
            :...:|||:.|.|:|.|::|||...||.||||..|....:||:.||....:|:::.|..||::|.
Frog   134 EQTGISQSVYMSGLLIGALLFGPLGDRIGRRPVILLSMLLQLVFGLSAAFAPHFYVYTAFRWVVG 198

  Fly   171 VATAGTMTTSFVLLMEIVGPKKREMVAILYQIPFNIGHASLALFAYFIREWRWFQFSITIFSIVF 235
            .:.:|.|..:.||..|.||..:|....|...:.|.:|..:||..:|.||.||..|...:..:.:.
Frog   199 TSMSGLMINNLVLGAEWVGSSRRACATITAHVCFAVGLMALAGVSYGIRNWRLLQIVSSAPTALL 263

  Fly   236 VIYIWLVPESPRWLFTTGKLDKSIKILEKIAKCNKAPTETIRPEIEAAYGALAARQPVKKGTVVD 300
            ..|||::|||.|||.|.||.:|::|:|:|.|..||...    || :..:.....:.| |.|.::|
Frog   264 FFYIWVLPESARWLLTKGKKEKAVKLLKKAAAMNKKEI----PE-DLLFQFNEEKSP-KSGNMID 322

  Fly   301 LFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAGVGIPGTCLCALMTKYLG 365
            |||...:|..|:.|...|.|..:||||.:..|.:.|.:|:::..:...|.||.........:..|
Frog   323 LFRNKTLRKLTLVMCLVWFVNSLVYYGLSLNVGSFGLDIYLTQLVFGAVEIPARIGAMFAVQLFG 387

  Fly   366 RKKTLLLSNGCSALG----LILLACLSTQAEAVRVTCATIGLFGASITFPNVYLYGGELFPTVVR 426
            ||.:.:.   |..||    ||:.|.......|:.: .|.||.|..:.:|...|:|..|:||||:|
Frog   388 RKPSQMF---CLFLGGTVCLIITAIPRNLPIAITI-LAVIGKFSIASSFSICYIYAAEVFPTVIR 448

  Fly   427 SSGVGLCSMVGRIGSIVAPLI---------VDLAAYGLWVAPLIFGIFSILAMLGTIFLPETRGT 482
            .:||||.||..|:..|.||||         :.:|.||  ..|:|.||...|       |||||..
Frog   449 QNGVGLASMAARVAGITAPLISLLDKYHAAIPMAIYG--SGPIIGGILCFL-------LPETRNK 504

  Fly   483 PLPETLEDGE 492
            .|.:..:..|
Frog   505 DLQDHTQQDE 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	145/414 (35%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	138/402 (34%)
slc22a13	XP_031760340.1	2A0119	12..509	CDD:273328	162/518 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920