DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and slc22a2

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	XP_002933908.1	Gene:	slc22a2 / 100487774	XenbaseID:	XB-GENE-965056	Length:	544	Species:	Xenopus tropicalis

Alignment Length:	542	Identity:	151/542 - (27%)
Similarity:	246/542 - (45%)	Gaps:	78/542 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 TGDPIISQIGDFRRYQLFFFFIVLLCKFGTGWHTL--GHIFLAAPTPLSCKTENVTDPCSDECSE 82
            |.|.::..||:|..:|...|  :|||.....:..:  |.:||.......|.:..:.:| |:||..
Frog     3 TFDELLEHIGEFDAFQKQIF--ILLCFISVVFSPIYVGIVFLGFVPDYRCVSAGIPEP-SNECEW 64

  Fly    83 T--------------------------------------------------EFDTSVFQSTIITE 97
            |                                                  .:|.:...|:::||
Frog    65 TLNYTGPNGSTDSLYMSQCYQYDVDWNSTSLNCTNSSLNITSKLPITNCKDGWDYNTTGSSLVTE 129

  Fly    98 WNLTCESKQLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGLIVCVSPYYWFY 162
            :||.|.........||.|.:|...|.::.|..|||:||:|..::...:..|.|:::..:|.|...
Frog   130 FNLVCGDSWKLDFFQSCVNIGFFIGGLISGYIADRFGRKPFLISSILITGIFGILMAFAPNYPLV 194

  Fly   163 CLFRFLVAVATAGTMTTSFVLLMEIVGPKKREMVAILYQIPFNIGHASLALFAYFIREWRWFQFS 227
            ..|||:....:.|...:.::|:.|.||.:.|..|.|:||..|.:|...|:..||.:..|||.|.:
Frog   195 VTFRFIQGFVSKGCWLSGYILVAEFVGLEHRRTVGIVYQAAFTVGLLLLSGVAYVLPHWRWLQMT 259

  Fly   228 ITIFSIVFVIYIWLVPESPRWLFTTGKLDKSIKILEKIAKCNKAPTETIRPEIEAAYGALAARQP 292
            :||....|:.|.|.||||||||.:..:..::..|:..|||.|..........:.|...|...:.|
Frog   260 VTIPYFFFLAYYWCVPESPRWLISQNRKAEAKAIIHTIAKKNGKMVPDFLESLTADEEAGEKQVP 324

  Fly   293 VKKGTVVDLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAGVGIPGTCLC 357
                :.:||.|||.:|..|:.:...|....:||.|:..::.:...||:....|:|.|..|...|.
Frog   325 ----SFLDLVRTPQIRKHTLILMYIWFTCAVVYQGSIMHMGSTAENIYFDFFISALVEFPSAILI 385

  Fly   358 ALMTKYLGRKKTLLLSNGCSALGLILLACLSTQ-----AEAVRVTCATIGLFGASITFPNVYLYG 417
            .:....:||:...|:.  |...|   :.||.|.     ...:.:|.:.:...|.::::..|.|..
Frog   386 IVTVDRVGRRYPWLVC--CIITG---ITCLITAFIPHGYSWLIITLSCVSRMGITVSYEMVCLVN 445

  Fly   418 GELFPTVVRSSGVGLCSMVGRIGSIVAPLIV-DLAAYGLW-VAPLIFGIFSILAMLGTI---FLP 477
            .||:||.:|:.|:.:||.:..:|.::.|.|| .|||  :| ..|||  :|::||.:..|   |||
Frog   446 AELYPTFIRNLGIMVCSSMCDLGGVITPFIVYRLAA--IWQELPLI--VFAVLATVSGILVYFLP 506

  Fly   478 ETRGTPLPETLEDGETFGRKKK 499
            ||:|..||||:|:.|...::.|
Frog   507 ETKGRALPETIEEAENLHKQVK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	127/411 (31%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	119/399 (30%)
slc22a2	XP_002933908.1	2A0119	12..516	CDD:273328	143/519 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010