DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and slc22a13a

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	XP_021322911.1	Gene:	slc22a13a / 100007819	ZFINID:	ZDB-GENE-070912-473	Length:	537	Species:	Danio rerio

Alignment Length:	525	Identity:	145/525 - (27%)
Similarity:	244/525 - (46%)	Gaps:	63/525 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 IISQIGDFRRYQLFFFFIVLLCKFGTGWHTLGHIFLAAPTPLSCKTE---------------NVT 73
            |:..||||..:|....|.:........:.....:|..|.|...|.|:               |:|
Zfish     7 ILEAIGDFGLFQKLLLFALCFPNLILPFQLSSLVFNHADTNHHCNTDWILKADPNLTKEEQLNLT 71

  Fly    74 ---------DPC--------------------SDECSE--TEFDTSVFQSTIITEWNLTCESKQL 107
                     :||                    :..|::  ...|| ::::||:|:::|.||:..:
Zfish    72 LPRLSDGSFNPCQMYKPVDWNLSAIQEYGLNQTTTCTDGWVHNDT-IYEATIVTDFDLVCENVNI 135

  Fly   108 ASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGLIVCVSPYYWFYCLFRFLVAVA 172
            ...:|::...|:|.|:||||.|::.:||:.|......:.||..::..:||.::.|.:.:|:..|.
Zfish   136 FRGAQTVFFAGVLVGAILFGPFSESFGRKRATQIPMVLMLIFTVVTGLSPNFYVYLVSQFINGVG 200

  Fly   173 TAGTMTTSFVLLMEIVGPKKREMVAILYQIPFNIGHASLALFAYFIREWRWFQFSITIFSIVFVI 237
            ..|....|.:|..|.:|..:|...|.|.|:...:|........||:|:||..||.:.....:.||
Zfish   201 LGGFRINSIILASEWIGVAQRSYAACLSQVLAALGQVMFLAVVYFVRDWRLDQFIMAGPIGIVVI 265

  Fly   238 YIWLVPESPRWLFTTGKLDKSIKILEKIAKCNK-APTETIRPEIEAAYGALAARQPVKKGTVVDL 301
            |||.:|||.|||...|:...:.|:::|.|..|| |..|::..|:       ...:||:||.:..|
Zfish   266 YIWFLPESARWLLDRGRTKDAKKLIQKAAAVNKRAVPESLVEEV-------LKEKPVEKGGIKIL 323

  Fly   302 FRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAGVGIPGTCLCALMTKYLGR 366
            |.:..:|...:.:...|..:.:.||..:..|...|.:||::..|.....||...||....:.:||
Zfish   324 FGSRVLRKYFLAITFAWCALNLAYYSLSLNVGKFGLDIFLTQLIFGLSEIPVHFLCMWSLEVVGR 388

  Fly   367 KKTLLLS---NGCSALGLILLACLSTQAEAVRVTCATIGLFGASITFPNVYLYGGELFPTVVRSS 428
            |.:|::|   .||..|..:.:...|:.|.||..||... |..|:.:..|||..  |||||.:|.:
Zfish   389 KPSLIVSLVLGGCLCLLTVAVPQNSSIAIAVLATCGRF-LMNAAGSVCNVYFQ--ELFPTSIRQT 450

  Fly   429 GVGLCSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLGTIFLPETRGTPLPETLEDGET 493
            ..||.|...|.||:::|::..|..:...:..::....::.:.:....|||||.|.||.:.|:.|
Zfish   451 ATGLGSTAARAGSMLSPVVNMLEIFHFSIPMVVISSLALASGVTAFLLPETRRTELPASTEEAE- 514

  Fly   494 FGRKK 498
             |::|
Zfish   515 -GKRK 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	124/405 (31%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	115/393 (29%)
slc22a13a	XP_021322911.1	Sugar_tr	12..507	CDD:331684	137/505 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.020