DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8654 and si:dkey-166k12.1

DIOPT Version :9

Sequence 1:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	XP_001341287.1	Gene:	si:dkey-166k12.1 / 100001249	ZFINID:	ZDB-GENE-120215-78	Length:	537	Species:	Danio rerio

Alignment Length:	510	Identity:	166/510 - (32%)
Similarity:	261/510 - (51%)	Gaps:	49/510 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DPIISQIGDFRRYQLFFFFIVLLCKFGTGWHTLGHIFLAAPTPLSCK-----------TENVT-- 73
            |.:::.||.|.:||...:..:.|.:...|:|.:..:|..|..|..|:           |.|::
Zfish     4 DQLLATIGGFGKYQKLLYVWICLPQIFLGFHMMASVFTGATPPHRCRGSTSGMEDWTFTSNLSHV 68

  Fly    74 -----------DPCS-----DECSETEFDT------SVFQSTIITEWNLTCESKQLASLSQSIVM 116
                       |.|:     :..:.|..:|      .|||||.:|||:|.|:.:.|:||..||.|
Zfish    69 NLSISRLAGFADACTAASGVNRSARTNCETGWVYSHEVFQSTTVTEWDLVCDKRGLSSLGSSIYM 133

  Fly   117 LGILFGSILFGMFADRYGRRPAFLTCCFMQLITGLIVCVSPYYWFYCLFRFLVAVATAGTMTTSF 181
            ||:|.|:::||..|||||||.|.|....:|.:.|:....:|.:..|...||::.:..:|.:..:|
Zfish   134 LGLLVGAVVFGAMADRYGRRFAMLVSLALQTVFGVAAAFAPNFPVYVGLRFIIGMTVSGVIINAF 198

  Fly   182 VLLMEIVGPKKREMVAILYQIPFNIGHASLALFAYFIREWRWFQFSITIFSIVFVIYIWLVPESP 246
            ||..|....::|.:..|.....|..|:..||..|:.||:||..|.:|:....:|:.|||::|.|.
Zfish   199 VLGTEWTCTQRRMLAGIFTDYFFGFGYMLLAGVAFLIRDWRKLQLAISAPGFLFIFYIWVLPHSA 263

  Fly   247 RWLFTTGKLDKSIKILEKIAKCNKAPTETIRPEIEA-AYGALAARQPVKKGTVVDLFRTPYMRIK 310
            |||....:.:::|.:|.|.|..|   ..|:.|.::. .|.:...|   .|.|||||.|||.||.:
Zfish   264 RWLLVNNRKEEAIDLLRKAASVN---GRTLPPTVQVERYESPQGR---SKYTVVDLLRTPQMRKR 322

  Fly   311 TIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAGVGIPGTCLCALM---TKYLGRKKTLLL 372
            .:.:...|.|..:||||.:..||.||.:::::..:...|.||...|..::   ::.:.....|::
Zfish   323 ALILFYIWFVNVLVYYGLSLGVSDLGADLYLTQFMFGLVEIPARTLVLVLLPCSRKIPLSVFLVV 387

  Fly   373 SNGCSALGLILLACLSTQAEAVRVTCATIGLFGASITFPNVYLYGGELFPTVVRSSGVGLCSMVG 437
            ..|...|.|.|.|    .:..||...|.:|.||.:.:|..:|:|..||||||:|.:|:|:.||..
Zfish   388 GGGACLLTLTLPA----DSAHVRTALAMVGKFGITASFAIIYVYSAELFPTVLRQTGIGVSSMFA 448

  Fly   438 RIGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLGTIFLPETRGTPLPETLEDGE 492
            |:|.::||||..|..:...|..||||...:||....:.||||...|||:::.|.|
Zfish   449 RMGGVLAPLINLLGRHTPVVPMLIFGSTPLLAAALALALPETARQPLPDSIHDTE 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8654	NP_001246441.1	SP	85..487	CDD:273317	146/411 (36%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	139/399 (35%)
si:dkey-166k12.1	XP_001341287.1	2A0119	11..497	CDD:273328	161/495 (33%)
si:dkey-166k12.1	XP_001341287.1	MFS	123..458	CDD:119392	118/344 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	8.010