DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and CYR1

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_012529.3	Gene:	CYR1 / 853452	SGDID:	S000003542	Length:	2026	Species:	Saccharomyces cerevisiae

Alignment Length:	860	Identity:	199/860 - (23%)
Similarity:	331/860 - (38%)	Gaps:	225/860 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 STLPVAVFARLQTLEALRLDSCKLLQLPNNAFEGLATLKSLRLSTHNSEWGPTRTLELFPDSLGG 187
            :|.|:..:.....:|:|.:.:...:.||....|....|.|||:....:        ..||.::..
Yeast   805 TTPPIIFYQHTSEIESLDVSNNANIFLPLEFIESSIKLLSLRMVNIRA--------SKFPSNITK 861

  Fly   188 LKQLTDLDLGDNNLRQLPSGFLCPVGNLQVLNLTRNRIRTAEQMGFADMNCGAGSGSAGSELQVL 252
            ..:|..|:|..|.:|::|:..: .:.||.:|||..|.:.:. ..||.::          ..||:|
Yeast   862 AYKLVSLELQRNFIRKVPNSIM-KLSNLTILNLQCNELESL-PAGFVEL----------KNLQLL 914

  Fly   253 DASHNELRSISESWGISRLRRLQHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLETLPEGLFA 317
            |.|.|:.....|.  |:....|..::|:||.:..|. ::...|..|..:|||:|.|..:  |..:
Yeast   915 DLSSNKFMHYPEV--INYCTNLLQIDLSYNKIQSLP-QSTKYLVKLAKMNLSHNKLNFI--GDLS 974

  Fly   318 GSKELREIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNLAHNAL 382
            ...:||.::|:.|.:..: |.....|:.|.:.|   |:: ||..|.     |.:|..|.:..|.:
Yeast   975 EMTDLRTLNLRYNRISSI-KTNASNLQNLFLTD---NRI-SNFEDT-----LPKLRALEIQENPI 1029

  Fly   383 TRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLNLAENRLHTLDDKLFNGLYVLSKL 447
            |.|   :||:.|                     | .|:.:|.|.:.:|.::..:|...|..|.||
Yeast  1030 TSI---SFKDFY---------------------P-KNMTSLTLNKAQLSSIPGELLTKLSFLEKL 1069

  Fly   448 TLN-NNLISVVEPAVFKNCSDLKELDLSSNQLNEVPRALQDLAMLRTLDLGENQIRTFDNQSFKN 511
            .|| |||..:  |......:.|..|.::.|:|..:|..|..|..||||||..|.||.|.: ..:|
Yeast  1070 ELNQNNLTRL--PQEISKLTKLVFLSVARNKLEYIPPELSQLKSLRTLDLHSNNIRDFVD-GMEN 1131

  Fly   512 LHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQSIERGSFDKNFELEAIRLDRNFLADI 576
            | :||.|.:..|..||                      .|:| .||..|....: :|.:
Yeast  1132 L-ELTSLNISSNAFGN----------------------SSLE-NSFYHNMSYGS-KLSK------ 1165

  Fly   577 NGVFATLVSLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVKTLDASHN 641
                    ||::...::|.   ||.|..|               |.|.:     :.:|.|:.|:|
Yeast  1166 --------SLMFFIAADNQ---FDDAMWP---------------LFNCF-----VNLKVLNLSYN 1199

  Fly   642 RITEIGPMSIPNTIELLFINNNLIGNVQPNAFVDKANLARVDLYANQLSKL-----QLQQLRVAP 701
            ..:::..|.:.:..| |:::.|.:..:..:..:..::|..:.|.:||:..|     .|.||.|
Yeast  1200 NFSDVSHMKLESITE-LYLSGNKLTTLSGDTVLKWSSLKTLMLNSNQMLSLPAELSNLSQLSV-- 1261

  Fly   702 VVAPKPLPEFYLGGNPFECDCT---MDWLQRINNLTTRQHPRVMDMANIECVMPHARGAAVRPLS 763
                     |.:|.|..:.:.:   .||..|.|        :.:...|               .|
Yeast  1262 ---------FDVGANQLKYNISNYHYDWNWRNN--------KELKYLN---------------FS 1294

  Fly   764 GLRPQDFLCRYESHCFALCHCCDFDACDCE----------MTCPSNCTCYHDQ-----IWST--- 810
            |.|      |:|...| :.|..|.|..|..          |....|.|...|:     :.:|
Yeast  1295 GNR------RFEIKSF-ISHDIDADLSDLTVLPQLKVLGLMDVTLNTTKVPDENVNFRLRTTASI 1352

  Fly   811 ------NVVDCGGQQTTELPRRVPMDSSVVYLDGNNFPVLKNHAFIGRKNLRALYVNGSQVAAIQ 869
                  .|.|..||:.....|.|..:.    ..||:...|.  .....||..|.|  |..::.|.
Yeast  1353 INGMRYGVADTLGQRDYVSSRDVTFER----FRGNDDECLL--CLHDSKNQNADY--GHNISRIV 1409

  Fly   870 NRTFASLASLQLLHL---ADNKLRTLHGYEFEQLSALRELYLQNNQLTTIEN-ATLAPLAALEL- 929
            ...:..:...||...   .|:.::|...:.|.||:  :|:   |..|.:::| |.:|.|:..:|
Yeast  1410 RDIYDKILIRQLERYGDETDDNIKTALRFSFLQLN--KEI---NGMLNSVDNGADVANLSYADLL 1469

  Fly   930 -------IRIDGNRL 937
                   |.|.|.:|
Yeast  1470 SGACSTVIYIRGKKL 1484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	15/65 (23%)
		leucine-rich repeat	136..159	CDD:275380	5/22 (23%)
		leucine-rich repeat	160..190	CDD:275380	6/29 (21%)
		LRR_8	189..259	CDD:290566	20/69 (29%)
		leucine-rich repeat	191..214	CDD:275380	6/22 (27%)
		leucine-rich repeat	215..248	CDD:275380	7/32 (22%)
		LRR_RI	247..501	CDD:238064	72/254 (28%)
		LRR_8	247..308	CDD:290566	19/60 (32%)
		leucine-rich repeat	249..273	CDD:275380	8/23 (35%)
		leucine-rich repeat	274..297	CDD:275380	6/22 (27%)
		LRR_8	297..356	CDD:290566	16/58 (28%)
		leucine-rich repeat	298..321	CDD:275380	7/22 (32%)
		leucine-rich repeat	322..345	CDD:275380	6/22 (27%)
		LRR_8	345..406	CDD:290566	15/60 (25%)
		leucine-rich repeat	346..371	CDD:275380	7/24 (29%)
		leucine-rich repeat	372..395	CDD:275380	7/22 (32%)
		leucine-rich repeat	396..419	CDD:275380	1/22 (5%)
		LRR_8	419..478	CDD:290566	18/59 (31%)
		leucine-rich repeat	420..443	CDD:275380	5/22 (23%)
		leucine-rich repeat	444..467	CDD:275380	9/23 (39%)
		LRR_RI	466..622	CDD:238064	38/155 (25%)
		leucine-rich repeat	468..488	CDD:275380	6/19 (32%)
		LRR_8	491..549	CDD:290566	18/57 (32%)
		leucine-rich repeat	491..514	CDD:275380	12/22 (55%)
		leucine-rich repeat	515..536	CDD:275380	6/20 (30%)
		leucine-rich repeat	539..562	CDD:275380	5/22 (23%)
		leucine-rich repeat	563..585	CDD:275380	1/21 (5%)
		leucine-rich repeat	586..626	CDD:275380	8/39 (21%)
		leucine-rich repeat	627..653	CDD:275380	5/25 (20%)
		LRRCT	716..772	CDD:214507	9/58 (16%)
		LRRNT	796..830	CDD:214470	10/47 (21%)
		leucine-rich repeat	812..829	CDD:275380	6/16 (38%)
		leucine-rich repeat	833..854	CDD:275380	3/20 (15%)
		LRR_8	853..913	CDD:290566	15/62 (24%)
		leucine-rich repeat	855..878	CDD:275380	4/22 (18%)
		LRR_4	878..918	CDD:289563	10/42 (24%)
		leucine-rich repeat	879..902	CDD:275380	7/25 (28%)
		leucine-rich repeat	903..926	CDD:275380	7/23 (30%)
		leucine-rich repeat	927..953	CDD:275380	5/19 (26%)
		TIR	1098..1235	CDD:214587
CYR1	NP_012529.3	Ad_cyc_g-alpha	368..418	CDD:369912
		RA_PHLPP_like	678..776	CDD:340473
		PLN00113	792..>1273	CDD:215061	145/604 (24%)
		leucine-rich repeat	796..817	CDD:275380	2/11 (18%)
		leucine-rich repeat	818..839	CDD:275380	5/20 (25%)
		leucine-rich repeat	840..864	CDD:275380	6/31 (19%)
		leucine-rich repeat	865..887	CDD:275380	6/22 (27%)
		leucine-rich repeat	888..910	CDD:275380	7/32 (22%)
		leucine-rich repeat	911..933	CDD:275380	8/23 (35%)
		leucine-rich repeat	934..956	CDD:275380	6/22 (27%)
		leucine-rich repeat	957..978	CDD:275380	7/22 (32%)
		leucine-rich repeat	979..1018	CDD:275380	13/48 (27%)
		leucine-rich repeat	1019..1041	CDD:275380	9/46 (20%)
		leucine-rich repeat	1042..1065	CDD:275380	5/22 (23%)
		leucine-rich repeat	1066..1088	CDD:275380	9/23 (39%)
		leucine-rich repeat	1089..1111	CDD:275380	7/21 (33%)
		leucine-rich repeat	1167..1187	CDD:275380	7/37 (19%)
		leucine-rich repeat	1191..1211	CDD:275380	5/19 (26%)
		leucine-rich repeat	1236..1258	CDD:275380	6/21 (29%)
		leucine-rich repeat	1259..1287	CDD:275380	9/46 (20%)
		PP2C	1374..1617	CDD:395385	29/124 (23%)
		CYCc	1613..1825	CDD:214485
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	1	Normalized mean entropy	S3577
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.860