DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-7 and RLP12

DIOPT Version :9

Sequence 1:NP_523797.1 Gene:Toll-7 / 37272 FlyBaseID:FBgn0034476 Length:1446 Species:Drosophila melanogaster
Sequence 2:NP_177296.2 Gene:RLP12 / 843481 AraportID:AT1G71400 Length:847 Species:Arabidopsis thaliana


Alignment Length:886 Identity:206/886 - (23%)
Similarity:335/886 - (37%) Gaps:265/886 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    51 SSLLSNVPAASP-----------------VPANPS-----QPSGPANQ----CSWSYNGTSSVHC 89
            |.|:.::.::||                 .|.|.|     |..||.|:    |.|  ||.:....
plant    20 SLLVHSLASSSPHFCRDDQRDALLEFRGEFPINASWHIMNQWRGPWNKSTDCCLW--NGVTCNDK 82

  Fly    90 ALRLIERQPGLDLQGADGSSQLTIQCSELYLFESTLPVAVFARLQTLEALRLDSCKL-------- 146
            :.::|    .||:.....::.|....|   ||          :||.|..|.|.:|.|        
plant    83 SGQVI----SLDIPNTFLNNYLKTNSS---LF----------KLQYLRHLDLTNCNLYGEIPSSL 130

  Fly   147 -----LQLPN---NAFEG-----LATLKSLR--LSTHNSEWG--PTR--------TLELF----- 181
                 |.|.|   |.|.|     :..|..||  :..:|...|  |:.        .||||     
plant   131 GNLSHLTLVNLYFNKFVGEIPASIGNLNQLRHLILANNVLTGEIPSSLGNLSRLVNLELFSNRLV 195

  Fly   182 ---PDSLGGLKQLTDLDLGDNNL-RQLPSGFLCPVGNLQVLNLTRNRIRTAEQMGFADMNCGAGS 242
               |||:|.||||.:|.|..||| .::||. |..:.||..|.||.|::            .|...
plant   196 GKIPDSIGDLKQLRNLSLASNNLIGEIPSS-LGNLSNLVHLVLTHNQL------------VGEVP 247

  Fly   243 GSAGS--ELQVLDASHNELRS----------------ISES-------WGISRLRRLQHLNLAYN 282
            .|.|:  ||:|:...:|.|..                :|.:       :.:|....|::.:::||
plant   248 ASIGNLIELRVMSFENNSLSGNIPISFANLTKLSIFVLSSNNFTSTFPFDMSIFHNLEYFDVSYN 312

  Fly   283 NLSELSGEALAGLASLRIVNLSNNHLETLPEGLFA---GSKELREIHLQQNELY-ELPKGLFHRL 343
            :.|....::|..:.||..:.|..|......|  ||   .|.:|:::.|.:|.|: .:|:.: .||
plant   313 SFSGPFPKSLLLIPSLESIYLQENQFTGPIE--FANTSSSTKLQDLILGRNRLHGPIPESI-SRL 374

  Fly   344 EQLLVVDLSGN-------------------QLTSNHVDNTTFAGLIRLIVLNLAHNALTRIDYRT 389
            ..|..:|:|.|                   .|:.|:::....|.|.||..:.|:||:.:..: .|
plant   375 LNLEELDISHNNFTGAIPPTISKLVNLLHLDLSKNNLEGEVPACLWRLNTMVLSHNSFSSFE-NT 438

  Fly   390 FKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLNLAENRLHTLDDKLFNG--LYVLSKLT---- 448
            .:|...::.|:|.:||                                |.|  .|::.||:    
plant   439 SQEEALIEELDLNSNS--------------------------------FQGPIPYMICKLSSLGF 471

  Fly   449 --LNNNLISVVEPAVFKNCS-DLKELDLSSNQLN-EVPRALQDLAMLRTLDLGENQIRTFDNQSF 509
              |:|||.|...|:..:|.| .:|||:|..|..: .:|........|.:||:..||:.....:|.
plant   472 LDLSNNLFSGSIPSCIRNFSGSIKELNLGDNNFSGTLPDIFSKATELVSLDVSHNQLEGKFPKSL 536

  Fly   510 KNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQS--IERGSFDKNFELEAIRLDRNF 572
            .|...|..:.:..|:|.:|.....:.||.|.||||..|:...  ..|.:   :...:::|     
plant   537 INCKALELVNVESNKIKDIFPSWLESLPSLHVLNLRSNKFYGPLYHRHA---SIGFQSLR----- 593

  Fly   573 LADI--NGVFATLVSLLWLNLSENHLVWFDYAFIPSNL-KWLDIHGNYIEALGNYYKLQ------ 628
            :.||  |....||....:.|       |.|...:...: :::.....|.::.  |::::      
plant   594 IIDISHNNFSGTLPPYYFSN-------WKDMTTLTEEMDQYMTEFWRYADSY--YHEMEMVNKGV 649

  Fly   629 ----EEIR--VKTLDASHNRITEIGPMSIPNTIELLFIN--NNLIGNVQPNAFVDKANLARVDLY 685
                |.||  .:.:|.|.|:|....|.|:....||..:|  .|...:|.|....:...|..:|:.
plant   650 DMSFERIRRDFRAIDFSGNKINGNIPESLGYLKELRVLNLSGNAFTSVIPRFLANLTKLETLDIS 714

  Fly   686 ANQLSKLQLQQLRVAPVVA---------PKPLPEFYLGGNPFE---CDCTMDWLQRINNLTTRQH 738
            .|:||....|.|.....::         ..|:|.    |..|:   |...:|            :
plant   715 RNKLSGQIPQDLAALSFLSYMNFSHNLLQGPVPR----GTQFQRQKCSSFLD------------N 763

  Fly   739 PRVMDMANIECVMPHARGAAVRPLSGLRPQDFLCRYESHCF 779
            |.:..:.:| |    ....|:.|.|.| |:| |...|.:.|
plant   764 PGLYGLEDI-C----RDTGALNPTSQL-PED-LSEAEENMF 797

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-7NP_523797.1 LRR_8 135..201 CDD:290566 32/106 (30%)
leucine-rich repeat 136..159 CDD:275380 11/43 (26%)
leucine-rich repeat 160..190 CDD:275380 15/49 (31%)
LRR_8 189..259 CDD:290566 24/72 (33%)
leucine-rich repeat 191..214 CDD:275380 9/23 (39%)
leucine-rich repeat 215..248 CDD:275380 8/34 (24%)
LRR_RI 247..501 CDD:238064 69/311 (22%)
LRR_8 247..308 CDD:290566 16/85 (19%)
leucine-rich repeat 249..273 CDD:275380 6/46 (13%)
leucine-rich repeat 274..297 CDD:275380 5/22 (23%)
LRR_8 297..356 CDD:290566 19/81 (23%)
leucine-rich repeat 298..321 CDD:275380 7/25 (28%)
leucine-rich repeat 322..345 CDD:275380 7/23 (30%)
LRR_8 345..406 CDD:290566 18/79 (23%)
leucine-rich repeat 346..371 CDD:275380 8/43 (19%)
leucine-rich repeat 372..395 CDD:275380 6/22 (27%)
leucine-rich repeat 396..419 CDD:275380 4/22 (18%)
LRR_8 419..478 CDD:290566 18/67 (27%)
leucine-rich repeat 420..443 CDD:275380 2/24 (8%)
leucine-rich repeat 444..467 CDD:275380 10/29 (34%)
LRR_RI 466..622 CDD:238064 37/162 (23%)
leucine-rich repeat 468..488 CDD:275380 6/20 (30%)
LRR_8 491..549 CDD:290566 19/57 (33%)
leucine-rich repeat 491..514 CDD:275380 7/22 (32%)
leucine-rich repeat 515..536 CDD:275380 4/20 (20%)
leucine-rich repeat 539..562 CDD:275380 7/24 (29%)
leucine-rich repeat 563..585 CDD:275380 6/23 (26%)
leucine-rich repeat 586..626 CDD:275380 5/40 (13%)
leucine-rich repeat 627..653 CDD:275380 9/37 (24%)
LRRCT 716..772 CDD:214507 12/58 (21%)
LRRNT 796..830 CDD:214470
leucine-rich repeat 812..829 CDD:275380
leucine-rich repeat 833..854 CDD:275380
LRR_8 853..913 CDD:290566
leucine-rich repeat 855..878 CDD:275380
LRR_4 878..918 CDD:289563
leucine-rich repeat 879..902 CDD:275380
leucine-rich repeat 903..926 CDD:275380
leucine-rich repeat 927..953 CDD:275380
TIR 1098..1235 CDD:214587
RLP12NP_177296.2 LRRNT_2 36..80 CDD:285463 11/45 (24%)
LRR_8 112..170 CDD:290566 15/57 (26%)
leucine-rich repeat 112..135 CDD:275380 5/22 (23%)
leucine-rich repeat 136..159 CDD:275380 7/22 (32%)
LRR_8 159..218 CDD:290566 20/58 (34%)
leucine-rich repeat 160..183 CDD:275380 5/22 (23%)
leucine-rich repeat 184..207 CDD:275380 9/22 (41%)
LRR_RI 198..479 CDD:238064 79/329 (24%)
LRR_8 206..266 CDD:290566 24/72 (33%)
leucine-rich repeat 208..231 CDD:275380 9/23 (39%)
leucine-rich repeat 232..255 CDD:275380 8/34 (24%)
leucine-rich repeat 256..279 CDD:275380 4/22 (18%)
leucine-rich repeat 280..352 CDD:275380 15/73 (21%)
leucine-rich repeat 304..322 CDD:275380 4/17 (24%)
LRR_8 351..411 CDD:290566 13/60 (22%)
leucine-rich repeat 353..376 CDD:275380 7/23 (30%)
LRR_RI 374..601 CDD:238064 62/267 (23%)
leucine-rich repeat 377..400 CDD:275380 4/22 (18%)
leucine-rich repeat 401..422 CDD:275380 4/20 (20%)
leucine-rich repeat 445..468 CDD:275380 9/54 (17%)
leucine-rich repeat 469..493 CDD:275380 8/23 (35%)
leucine-rich repeat 494..517 CDD:275380 6/22 (27%)
LRR_8 516..576 CDD:290566 19/59 (32%)
leucine-rich repeat 518..541 CDD:275380 7/22 (32%)
leucine-rich repeat 542..565 CDD:275380 5/22 (23%)
leucine-rich repeat 592..616 CDD:275380 8/35 (23%)
leucine-rich repeat 617..683 CDD:275380 11/67 (16%)
LRR_8 682..742 CDD:290566 13/59 (22%)
LRR_4 682..719 CDD:289563 9/36 (25%)
leucine-rich repeat 684..707 CDD:275380 5/22 (23%)
leucine-rich repeat 708..729 CDD:275380 7/20 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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