DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and RLP9

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_001185260.1	Gene:	RLP9 / 842186	AraportID:	AT1G58190	Length:	1029	Species:	Arabidopsis thaliana

Alignment Length:	940	Identity:	214/940 - (22%)
Similarity:	354/940 - (37%)	Gaps:	232/940 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 RTLEL--------FPD-----SLGGLKQLTDLDLGDNNLRQLPSGFLCPVGNLQVLNLTRNRIR- 226
            |||.|        |.|     |||.||:|..||:|:|.:......||....:|:.|.|..|.:.
plant   101 RTLNLYDFGCTGWFDDIHGYKSLGKLKKLEILDMGNNEVNNSVLPFLNAASSLRTLILHGNNMEG 165

  Fly   227 TAEQMGFADMNCGAGSGSAGSELQVLDASHNELRSISESWGISRLRRLQHLNLAYNNLSELSGEA 291
            |.......|:          |.|::||.|.|.|.....  |::.|.:|..|:|:.|..|...|.
plant   166 TFPMKELKDL----------SNLELLDLSGNLLNGPVP--GLAVLHKLHALDLSDNTFSGSLGR- 217

  Fly   292 LAGLASLRIVNLSNNHLETLPEGLFAGSKELREIHLQQNELYELPKGLFHRLEQLLVVDLSGNQL 356
                                     .|.|.                  |.||:.|.::|:|
plant   218 -------------------------EGYKS------------------FERLKNLEILDIS---- 235

  Fly   357 TSNHVDNTTFAGLIRLIVLNLAHNALTRIDYRTFKELYF--LQILNLRNNSIGHIEDNAFL-PL- 417
             .|.|:||.      |..:|.|.:..|.|.:....|..|  .:::||||..:..:..|.|: |:
plant   236 -ENGVNNTV------LPFINTASSLKTLILHGNNMEGTFPMKELINLRNLELLDLSKNQFVGPVP 293

  Fly   418 -----YNLHTLNLAENRLHTLDDKLFNGLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQ 477
                 :||..|::::|:        |:|        .|..|..:      ||   |:|||||.|:
plant   294 DLANFHNLQGLDMSDNK--------FSG--------SNKGLCQL------KN---LRELDLSQNK 333

  Fly   478 L-NEVPRALQDLAMLRTLDLGENQIRTFDNQSFKNLHQLTGLRLIDNQI-GNITVGMFQDLPRLS 540
            . .:.|:....|..|:.||:..|..........:||..:..|.|.||:. |..::.:..:|.:|.
plant   334 FTGQFPQCFDSLTQLQVLDISSNNFNGTVPSLIRNLDSVEYLALSDNEFKGFFSLELIANLSKLK 398

  Fly   541 VLNLA--KNRIQSIERGSFDKNFELEAIRLDRNFLADINGVFATLVSLLWLNLSENHLVW-FDYA 602
            |..|:  .|.::..:..|....|:|..|.|....|.::.........|..:|||.|.|.. |.|.
plant   399 VFKLSSRSNLLRLKKLSSLQPKFQLSVIELQNCNLENVPSFIQHQKDLHVINLSNNKLTGVFPYW 463

  Fly   603 FIPS--NLKWLDIHGNYIEALGNYYKLQEEIRVKTLDASH--NRITE-IGPMSIPNTIELLFINN 662
            .:..  ||:.|.:..|.:..|.....|...:::..|.|::  .|:.| ||.: :|| |..|.::|
plant   464 LLEKYPNLRVLLLQNNSLTMLELPRLLNHTLQILDLSANNFDQRLPENIGKV-LPN-IRHLNLSN 526

  Fly   663 NLIGNVQPNAFVDKANLARVDLYANQLS---------------KLQLQQLRVAPVVAPK-----P 707
            |....:.|::|.:..::..:||..|..|               .|:|...:....:.||     .
plant   527 NGFQWILPSSFGEMKDIKFLDLSHNNFSGSLPMKFLIGCSSLHTLKLSYNKFFGQIFPKQTNFGS 591

  Fly   708 LPEFYLGGNPFECDCTMDWLQRINNLTTRQHPRVMDMANIECVMPHARGAAVRPLSGLRPQDFLC 772
            |.......|.|  ....|.|:.:.:|      .|:|::|             ..|.|:.|..|..
plant   592 LVVLIANNNLF--TGIADGLRNVQSL------GVLDLSN-------------NYLQGVIPSWFGG 635

  Fly   773 RYESHCFALCHCCDFDACDCEMTCPSNCTCYHDQIWSTNVVDCGGQQ-TTELPRR-VPMDSSVVY 835
            .:.::.|...:.       .|.|.||  |.:....:  .::|..|.: :..||.. ..||.|::|
plant   636 FFFAYLFLSNNL-------LEGTLPS--TLFSKPTF--KILDLSGNKFSGNLPSHFTGMDMSLLY 689

  Fly   836 LDGNNFP--------------VLKNHA-------FIGRKNLRALYVNGSQVAAIQNRTFASLASL 879
            |:.|.|.              .|:|:.       |:..:.:.:|.:.|:.:..........|.|:
plant   690 LNDNEFSGTIPSTLIKDVLVLDLRNNKLSGTIPHFVKNEFILSLLLRGNTLTGHIPTDLCGLRSI 754

  Fly   880 QLLHLADNKLR-----TLHGYEFEQLSALRELYLQNNQLTTIENATLAPLAALELIRIDGNRLVT 939
            ::|.||:|:|:     .|:...|.:    |..|..|......|.......|..       :||:.
plant   755 RILDLANNRLKGSIPTCLNNVSFGR----RLNYEVNGDKLPFEINDDEEFAVY-------SRLLV 808

  Fly   940 LPIWQMHATHFGTRLKSISL-GRNQWSCRCQ----FLQALTSYVADNALI------VQDAQDIYC 993
            || .|....:.|..:.::.. .::::....|    |:..|.  ::.|.|.      :.|.|.|..
plant   809 LP-RQYSPDYTGVLMFNVEFASKSRYDSYTQESFNFMFGLD--LSSNELSGDIPKELGDLQRIRA 870

  Fly   994 MAASSGTGSAALEDSSSNSGSLEKRELDFN 1023
            :..|..:.|..:..|.||...:|..:|.||
plant   871 LNLSHNSLSGLIPQSFSNLTDIESIDLSFN 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	16/37 (43%)
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380	10/26 (38%)
		LRR_8	189..259	CDD:290566	20/70 (29%)
		leucine-rich repeat	191..214	CDD:275380	7/22 (32%)
		leucine-rich repeat	215..248	CDD:275380	6/33 (18%)
		LRR_RI	247..501	CDD:238064	64/263 (24%)
		LRR_8	247..308	CDD:290566	15/60 (25%)
		leucine-rich repeat	249..273	CDD:275380	8/23 (35%)
		leucine-rich repeat	274..297	CDD:275380	6/22 (27%)
		LRR_8	297..356	CDD:290566	8/58 (14%)
		leucine-rich repeat	298..321	CDD:275380	1/22 (5%)
		leucine-rich repeat	322..345	CDD:275380	3/22 (14%)
		LRR_8	345..406	CDD:290566	18/62 (29%)
		leucine-rich repeat	346..371	CDD:275380	7/24 (29%)
		leucine-rich repeat	372..395	CDD:275380	6/22 (27%)
		leucine-rich repeat	396..419	CDD:275380	7/29 (24%)
		LRR_8	419..478	CDD:290566	17/58 (29%)
		leucine-rich repeat	420..443	CDD:275380	5/22 (23%)
		leucine-rich repeat	444..467	CDD:275380	4/22 (18%)
		LRR_RI	466..622	CDD:238064	43/162 (27%)
		leucine-rich repeat	468..488	CDD:275380	8/20 (40%)
		LRR_8	491..549	CDD:290566	16/60 (27%)
		leucine-rich repeat	491..514	CDD:275380	6/22 (27%)
		leucine-rich repeat	515..536	CDD:275380	5/21 (24%)
		leucine-rich repeat	539..562	CDD:275380	5/24 (21%)
		leucine-rich repeat	563..585	CDD:275380	4/21 (19%)
		leucine-rich repeat	586..626	CDD:275380	13/42 (31%)
		leucine-rich repeat	627..653	CDD:275380	7/28 (25%)
		LRRCT	716..772	CDD:214507	12/55 (22%)
		LRRNT	796..830	CDD:214470	7/35 (20%)
		leucine-rich repeat	812..829	CDD:275380	4/18 (22%)
		leucine-rich repeat	833..854	CDD:275380	7/41 (17%)
		LRR_8	853..913	CDD:290566	14/64 (22%)
		leucine-rich repeat	855..878	CDD:275380	3/22 (14%)
		LRR_4	878..918	CDD:289563	11/44 (25%)
		leucine-rich repeat	879..902	CDD:275380	7/27 (26%)
		leucine-rich repeat	903..926	CDD:275380	4/22 (18%)
		leucine-rich repeat	927..953	CDD:275380	6/25 (24%)
		TIR	1098..1235	CDD:214587
RLP9	NP_001185260.1	LRRNT_2	32..68	CDD:285463
		LRR_RI	<92..240	CDD:238064	48/199 (24%)
		LRR	<120..>333	CDD:227223	75/304 (25%)
		leucine-rich repeat	129..152	CDD:275380	7/22 (32%)
		leucine-rich repeat	153..177	CDD:275380	6/33 (18%)
		LRR_RI	170..383	CDD:238064	71/304 (23%)
		leucine-rich repeat	178..200	CDD:275380	8/23 (35%)
		leucine-rich repeat	201..228	CDD:275380	11/70 (16%)
		leucine-rich repeat	229..277	CDD:275380	16/58 (28%)
		leucine-rich repeat	278..300	CDD:275380	3/21 (14%)
		leucine-rich repeat	301..323	CDD:275380	7/43 (16%)
		LRR_8	322..380	CDD:290566	19/60 (32%)
		leucine-rich repeat	324..347	CDD:275380	9/22 (41%)
		leucine-rich repeat	348..371	CDD:275380	6/22 (27%)
		leucine-rich repeat	372..396	CDD:275380	6/23 (26%)
		LRR_RI	422..673	CDD:238064	61/284 (21%)
		LRR_8	422..481	CDD:290566	16/58 (28%)
		leucine-rich repeat	423..445	CDD:275380	4/21 (19%)
		leucine-rich repeat	446..470	CDD:275380	8/23 (35%)
		leucine-rich repeat	471..493	CDD:275380	5/21 (24%)
		LRR_8	493..553	CDD:290566	17/61 (28%)
		leucine-rich repeat	494..518	CDD:275380	6/24 (25%)
		leucine-rich repeat	519..542	CDD:275380	6/22 (27%)
		leucine-rich repeat	543..567	CDD:275380	4/23 (17%)
		leucine-rich repeat	568..591	CDD:275380	4/22 (18%)
		leucine-rich repeat	592..614	CDD:275380	5/23 (22%)
		leucine-rich repeat	615..637	CDD:275380	8/40 (20%)
		leucine-rich repeat	638..661	CDD:275380	6/31 (19%)
		leucine-rich repeat	662..684	CDD:275380	4/23 (17%)
		leucine-rich repeat	685..707	CDD:275380	5/21 (24%)
		leucine-rich repeat	730..753	CDD:275380	3/22 (14%)
		leucine-rich repeat	754..780	CDD:275380	7/29 (24%)
		leucine-rich repeat	781..867	CDD:275380	16/95 (17%)
		LRR_8	847..902	CDD:290566	15/56 (27%)
		leucine-rich repeat	868..891	CDD:275380	6/22 (27%)
		leucine-rich repeat	892..912	CDD:275380	4/9 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	126	1.000	Inparanoid score	I1925
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.050