DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and RLP7

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_175225.1	Gene:	RLP7 / 841206	AraportID:	AT1G47890	Length:	1019	Species:	Arabidopsis thaliana

Alignment Length:	790	Identity:	193/790 - (24%)
Similarity:	301/790 - (38%)	Gaps:	214/790 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 SPVPANPSQPSG----PANQCSWSYNGTSSVHCALRLIERQPGLDLQGAD--GSSQLTIQCSELY 119
            ||:||...:.:|    ..:|.|.|    ..:...|..:.:...|||..:|  |....    ..|.
plant   157 SPIPAEFDKLTGLERLDLSQSSLS----GQIPINLLQLTKLVSLDLSSSDFFGDESF----HYLS 213

  Fly   120 LFESTLPVAVFAR-LQTLEALRLDSCKLLQLPNNAFEGLATLKSLRLSTHNSEWGPTRTLELFPD 183
            :.:|.||  :.|| |:.|..|.:...|:.......|..:.:|:||.|:..|. :|.      ||.
plant   214 IDKSFLP--LLARNLRNLRELDMSYVKISSEIPEEFSNIRSLRSLNLNGCNL-FGE------FPS 269

  Fly   184 SLGGLKQLTDLDLGDN-NLRQLPSGFLCPVGNLQVLNLTRNRIR-TAEQMGFADMNCGAGSGSAG 246
            |:..:..|..:|||:| |||          |||.|.:...:.:: |.....|        ||:..
plant   270 SILLIPNLQSIDLGNNPNLR----------GNLPVFHENNSLLKLTILYTSF--------SGAIP 316

  Fly   247 SELQVLDASHNELRSISES---------WGISRLRRLQHLNLAYNNL------------------ 284
            ..:    :|...|.|::.|         :.:..|..|.||:|:.|||
plant   317 DSI----SSLKNLTSLTLSVSYFSGKIPFSLGNLSHLSHLSLSSNNLIGEIPSSIGNLNQLTNFY 377

  Fly   285 ---SELSGE---ALAGLASLRIVNLSNNHLE-TLPEGLFAGSK---------------------- 320
               ::|||.   .|:.|..|..::||:|... :||..:...||
plant   378 VGGNKLSGNLPATLSNLTKLNTISLSSNQFTGSLPPSISQLSKLKFFFADDNPFIGAILSPLLKI 442

  Fly   321 -ELREIHLQQNELYELP--KGLF--HRLEQLLV----------VDLSGNQLTSNHVDNTTFAGLI 370
             .|..|||..|:|.:|.  :.:|  ..||...:          :||  |..:|.....|.:...|
plant   443 PSLTRIHLSYNQLNDLVGIENIFMLPNLETFYIYHYNYTKVRPLDL--NVFSSLKQLGTLYISRI 505

  Fly   371 RLIVLNLAHNALTRIDYRTFKELYF------------LQILNLRNNSI-GHIEDNAFLPLYNLHT 422
            .:...|:..:..:.::|.:.:....            ||||:|.||.| |.:.|    .|:.:.|
plant   506 PISTTNITSDFPSNLEYLSLRSCNITDFPEFIRKGRNLQILDLSNNKIKGQVPD----WLWRMPT 566

  Fly   423 LN---LAENRL---HT--------------LDDKLFNGLYVLSKLTL------NNNLISVVEPAV 461
            ||   |:.|.|   |.              |....|.|...|...:|      |||....: |..
plant   567 LNSVDLSNNSLSGFHVSVKASPESQLTSVDLSSNAFQGPLFLPSKSLRYFSGSNNNFTGKI-PRS 630

  Fly   462 FKNCSDLKELDLSSNQLN-EVPRALQDL-AMLRTLDLGENQIRTFDNQSFKNLHQLTGLRLIDNQ 524
            ....|.|:.||||:|.|| .:|..|:.| :.|..|||..|.:.....:.|.|..:|..|.:..|:
plant   631 ICGLSSLEILDLSNNNLNGSLPWCLETLMSSLSDLDLRNNSLSGSLPEIFMNATKLRSLDVSHNR 695

  Fly   525 IGNITVGMFQDLPRLSVLNLAKNRIQSI---ERGSFDKNFELEAIRLDRN----FLADINGVFAT 582
            :.....|.......|.|||:..|||..:   |..|..|   |:.:.|..|    .|.:::||:..
plant   696 MEGKLPGSLTGCSSLEVLNVGSNRINDMFPFELNSLQK---LQVLVLHSNKFHGTLHNVDGVWFG 757

  Fly   583 LVSLLWLNLSENHLVWFDYAFIPSN--LKWL--------DIHGNYIE-------ALGNYYKL--- 627
            ...|..:::|.|..    :..:||:  :.|.        :|...||:       :||.|..|
plant   758 FPQLQIIDVSHNDF----FGILPSDYFMNWTAMSSKKDNNIEPEYIQNPSVYGSSLGYYTSLVLM 818

  Fly   628 -----QEEIRVKT----LDASHNRITEIGPMSIPNTIELLFIN---NNLIGNVQPNAFVDKANLA 680
                 .|..||.|    :|.|.|::....|.||....||..:|   |...|:: |::..:..||.
plant   819 SKGVSMEMERVLTIYTAIDLSGNQLHGKIPDSIGLLKELRILNMSSNGFTGHI-PSSLANLKNLE 882

  Fly   681 RVDLYANQLS 690
            .:|:..|.:|
plant   883 SLDISQNNIS 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	18/66 (27%)
		leucine-rich repeat	136..159	CDD:275380	4/22 (18%)
		leucine-rich repeat	160..190	CDD:275380	9/29 (31%)
		LRR_8	189..259	CDD:290566	17/71 (24%)
		leucine-rich repeat	191..214	CDD:275380	8/23 (35%)
		leucine-rich repeat	215..248	CDD:275380	6/33 (18%)
		LRR_RI	247..501	CDD:238064	87/365 (24%)
		LRR_8	247..308	CDD:290566	21/93 (23%)
		leucine-rich repeat	249..273	CDD:275380	5/32 (16%)
		leucine-rich repeat	274..297	CDD:275380	12/46 (26%)
		LRR_8	297..356	CDD:290566	21/96 (22%)
		leucine-rich repeat	298..321	CDD:275380	8/46 (17%)
		leucine-rich repeat	322..345	CDD:275380	9/26 (35%)
		LRR_8	345..406	CDD:290566	15/82 (18%)
		leucine-rich repeat	346..371	CDD:275380	5/34 (15%)
		leucine-rich repeat	372..395	CDD:275380	2/22 (9%)
		leucine-rich repeat	396..419	CDD:275380	11/23 (48%)
		LRR_8	419..478	CDD:290566	23/84 (27%)
		leucine-rich repeat	420..443	CDD:275380	10/42 (24%)
		leucine-rich repeat	444..467	CDD:275380	6/28 (21%)
		LRR_RI	466..622	CDD:238064	48/181 (27%)
		leucine-rich repeat	468..488	CDD:275380	10/20 (50%)
		LRR_8	491..549	CDD:290566	16/57 (28%)
		leucine-rich repeat	491..514	CDD:275380	7/22 (32%)
		leucine-rich repeat	515..536	CDD:275380	4/20 (20%)
		leucine-rich repeat	539..562	CDD:275380	10/25 (40%)
		leucine-rich repeat	563..585	CDD:275380	6/25 (24%)
		leucine-rich repeat	586..626	CDD:275380	12/56 (21%)
		leucine-rich repeat	627..653	CDD:275380	11/37 (30%)
		LRRCT	716..772	CDD:214507
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
RLP7	NP_175225.1	LRRNT_2	75..112	CDD:285463
		LRR_RI	<163..>285	CDD:238064	34/138 (25%)
		leucine-rich repeat	169..192	CDD:275380	4/26 (15%)
		leucine-rich repeat	193..228	CDD:275380	12/40 (30%)
		leucine-rich repeat	229..252	CDD:275380	4/22 (18%)
		leucine-rich repeat	253..276	CDD:275380	9/29 (31%)
		leucine-rich repeat	277..324	CDD:275380	17/68 (25%)
		leucine-rich repeat	325..396	CDD:275380	16/70 (23%)
		LRR_RI	<387..602	CDD:238064	47/220 (21%)
		leucine-rich repeat	397..420	CDD:275380	6/22 (27%)
		leucine-rich repeat	421..444	CDD:275380	0/22 (0%)
		leucine-rich repeat	445..469	CDD:275380	8/23 (35%)
		LRR_8	518..577	CDD:290566	17/62 (27%)
		leucine-rich repeat	520..542	CDD:275380	1/21 (5%)
		leucine-rich repeat	543..566	CDD:275380	11/26 (42%)
		LRR_RI	567..>744	CDD:238064	51/180 (28%)
		leucine-rich repeat	567..612	CDD:275380	10/44 (23%)
		LRR_8	590..647	CDD:290566	16/57 (28%)
		leucine-rich repeat	613..636	CDD:275380	5/23 (22%)
		leucine-rich repeat	637..661	CDD:275380	11/23 (48%)
		LRR_8	660..720	CDD:290566	16/59 (27%)
		leucine-rich repeat	662..685	CDD:275380	7/22 (32%)
		leucine-rich repeat	686..709	CDD:275380	4/22 (18%)
		LRR_8	708..771	CDD:290566	19/65 (29%)
		leucine-rich repeat	710..733	CDD:275380	9/22 (41%)
		leucine-rich repeat	734..760	CDD:275380	6/25 (24%)
		leucine-rich repeat	815..856	CDD:275380	11/40 (28%)
		LRR_8	855..915	CDD:290566	11/39 (28%)
		leucine-rich repeat	857..880	CDD:275380	5/23 (22%)
		leucine-rich repeat	881..904	CDD:275380	4/12 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000