DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and RLP6

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_175139.1	Gene:	RLP6 / 841101	AraportID:	AT1G45616	Length:	994	Species:	Arabidopsis thaliana

Alignment Length:	798	Identity:	196/798 - (24%)
Similarity:	293/798 - (36%)	Gaps:	221/798 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 SLSGDYSSLLSNVPAASPVPANPSQPSGPANQCSWSYNGTSSVH-CALRLIERQPGLDLQGADGS 108
            |.||..|..|..:.....:..:.|.|..|:   |.|......:| .||..:..:. ||:...|.|
plant   159 SFSGHISIKLLQLTNLVSLDLSSSFPYSPS---SLSIEKPLFLHLLALNFMNLRE-LDMSSVDIS 219

  Fly   109 SQLTIQCSELYLFES-TL---------PVAVFARLQTLEALRLD----------------SCKLL 147
            |.:.|:.|.::...| ||         |.:|.. :..||::.||                |...|
plant   220 SAIPIEFSYMWSLRSLTLKGCNLLGRFPNSVLL-IPNLESISLDHNLNLEGSLPNFLRNNSLLKL 283

  Fly   148 QLPNNAFEG-----------LATLK------------SLRLSTH--NSEWGPTRTLELFPDSLGG 187
            .:.|.:|.|           |.:||            |||..:|  |........:...|.|:..
plant   284 SIYNTSFSGTIPNSISNLKHLTSLKLQQSAFSGRIPSSLRSLSHLSNLVLSENNFVGEIPSSVSN 348

  Fly   188 LKQLTDLDLGDNNLR-QLPSGFLCPVGNLQVLNLTRNRIR-----TAEQMGFADMNCGAGSGSAG 246
            |||||..|:.||||. ..||..| .:..|:.:::..|...     |..|:...:......:...|
plant   349 LKQLTLFDVSDNNLNGNFPSSLL-NLNQLRYIDICSNHFTGFLPPTISQLSNLEFFSACDNSFTG 412

  Fly   247 ---------SELQVLDASHNELRSISESWGISRLRRLQHLNLAYNN-------------LSELSG 289
                     |.|..|..|:|:|...:....||.|..||.|.|..||             |..|..
plant   413 SIPSSLFNISSLTTLGLSYNQLNDTTNIKNISLLHNLQRLLLDNNNFKASQVDLDVFLSLKRLVS 477

  Fly   290 EALAGLASLRIVNLS-----NNHLETL----------PEGLFAGSKELREIHLQQNELY-ELPKG 338
            .||:|: .|...|::     ::|||.|          || .....:.|..|.|..|.:. ::|..
plant   478 LALSGI-PLSTTNITSDSEFSSHLEYLELSGCNIIEFPE-FIRNQRNLSSIDLSNNNIKGQVPNW 540

  Fly   339 LFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNLAHNALTRIDYRTFKELYFL------Q 397
            |: ||.:|..||||.|.|...:......:| .::::|:|:.||        |:...|:      .
plant   541 LW-RLPELSTVDLSNNSLIGFNGSLKALSG-SKIVMLDLSSNA--------FQGPLFMPPRGIQY 595

  Fly   398 ILNLRNNSIGHIEDNAFLPLYNLHTLNLAENRLHTLDDKLFNG-LYVLSKLTLNNNLISVVEPAV 461
            .|...||..|:|.. :...|.|...|:|:.|.||.|..:.... :..||.|.|.||.:....|.:
plant   596 FLGSYNNFTGYIPP-SICGLANPLILDLSNNNLHGLIPRCLEAQMSSLSVLNLRNNSLDGSLPNI 659

  Fly   462 FKNCSDLKELDLSSNQL-NEVPRALQDLAMLRTLDLGENQIRTFDNQSFKNLHQLTGLRLIDNQI 525
            |.|...|..||:|.|.| .::|.:|...:.|..|::..|.|    |.:|.
plant   660 FMNAKVLSSLDVSHNTLEGKLPASLAGCSALEILNVESNNI----NDTFP--------------- 705

  Fly   526 GNITVGMFQDLPRLSVLNLAKNRIQSIERGSFDKNFELEAIRLDRNFLADINGVF---------- 580
                 .....||:|.||.|..|            ||        |..|.:::||:
plant   706 -----FWLNSLPKLQVLVLRSN------------NF--------RGTLHNVDGVWFGFPLLRITD 745

  Fly   581 -------ATLVSLLWLN-----LSENHLVWF----DYAFIPSNL---------------KW--LD 612
                   .||.|..::|     .||..|.:.    ||.:..|.:               |:  :|
plant   746 VSHNDFVGTLPSDYFMNWTAISKSETELQYIGDPEDYGYYTSLVLMNKGVSMEMQRILTKYTVID 810

  Fly   613 IHGNYIEALGNYYKLQEEI----RVKTLDASHNRITEIGPMSIPN--TIELLFINNNLIGNVQPN 671
            ..||.|:.     |:.|.:    .:..|:.|.|..|...|.|:.|  .:|.|.|:.|.||...|.
plant   811 FAGNKIQG-----KIPESVGILKELHVLNLSSNAFTGHIPSSLANLTNLESLDISQNKIGGEIPP 870

  Fly   672 AFVDKANLARVDLYANQL 689
            .....::|..:::..|||
plant   871 ELGTLSSLEWINVSHNQL 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	27/106 (25%)
		leucine-rich repeat	136..159	CDD:275380	10/49 (20%)
		leucine-rich repeat	160..190	CDD:275380	10/43 (23%)
		LRR_8	189..259	CDD:290566	22/84 (26%)
		leucine-rich repeat	191..214	CDD:275380	10/23 (43%)
		leucine-rich repeat	215..248	CDD:275380	5/46 (11%)
		LRR_RI	247..501	CDD:238064	83/290 (29%)
		LRR_8	247..308	CDD:290566	22/78 (28%)
		leucine-rich repeat	249..273	CDD:275380	8/23 (35%)
		leucine-rich repeat	274..297	CDD:275380	11/35 (31%)
		LRR_8	297..356	CDD:290566	22/74 (30%)
		leucine-rich repeat	298..321	CDD:275380	8/37 (22%)
		leucine-rich repeat	322..345	CDD:275380	8/23 (35%)
		LRR_8	345..406	CDD:290566	17/66 (26%)
		leucine-rich repeat	346..371	CDD:275380	8/24 (33%)
		leucine-rich repeat	372..395	CDD:275380	5/22 (23%)
		leucine-rich repeat	396..419	CDD:275380	6/28 (21%)
		LRR_8	419..478	CDD:290566	21/59 (36%)
		leucine-rich repeat	420..443	CDD:275380	6/23 (26%)
		leucine-rich repeat	444..467	CDD:275380	9/22 (41%)
		LRR_RI	466..622	CDD:238064	42/199 (21%)
		leucine-rich repeat	468..488	CDD:275380	8/20 (40%)
		LRR_8	491..549	CDD:290566	13/57 (23%)
		leucine-rich repeat	491..514	CDD:275380	6/22 (27%)
		leucine-rich repeat	515..536	CDD:275380	0/20 (0%)
		leucine-rich repeat	539..562	CDD:275380	6/22 (27%)
		leucine-rich repeat	563..585	CDD:275380	6/38 (16%)
		leucine-rich repeat	586..626	CDD:275380	12/65 (18%)
		leucine-rich repeat	627..653	CDD:275380	7/29 (24%)
		LRRCT	716..772	CDD:214507
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
RLP6	NP_175139.1	LRRNT_2	37..93	CDD:311940
		PLN00113	<81..>174	CDD:331614	5/14 (36%)
		leucine-rich repeat	125..149	CDD:275380
		leucine-rich repeat	150..200	CDD:275380	10/43 (23%)
		leucine-rich repeat	208..231	CDD:275380	7/23 (30%)
		leucine-rich repeat	232..255	CDD:275380	5/23 (22%)
		PLN00113	234..>915	CDD:331614	176/719 (24%)
		leucine-rich repeat	256..279	CDD:275380	4/22 (18%)
		leucine-rich repeat	280..303	CDD:275380	4/22 (18%)
		leucine-rich repeat	304..351	CDD:275380	11/46 (24%)
		leucine-rich repeat	352..375	CDD:275380	10/23 (43%)
		leucine-rich repeat	376..399	CDD:275380	4/22 (18%)
		leucine-rich repeat	400..423	CDD:275380	1/22 (5%)
		leucine-rich repeat	475..487	CDD:275378	5/12 (42%)
		leucine-rich repeat	500..522	CDD:275380	5/22 (23%)
		leucine-rich repeat	523..546	CDD:275380	8/23 (35%)
		leucine-rich repeat	547..571	CDD:275380	8/24 (33%)
		leucine-rich repeat	572..592	CDD:275380	6/27 (22%)
		leucine-rich repeat	593..616	CDD:275380	6/23 (26%)
		leucine-rich repeat	617..641	CDD:275380	6/23 (26%)
		leucine-rich repeat	642..665	CDD:275380	9/22 (41%)
		leucine-rich repeat	666..689	CDD:275380	8/22 (36%)
		leucine-rich repeat	690..713	CDD:275380	7/46 (15%)
		leucine-rich repeat	741..805	CDD:275380	10/63 (16%)
		leucine-rich repeat	806..829	CDD:275380	6/27 (22%)
		leucine-rich repeat	830..853	CDD:275380	7/22 (32%)
		leucine-rich repeat	854..877	CDD:275380	7/22 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000