DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and RLP53

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_001332753.1	Gene:	RLP53 / 832764	AraportID:	AT5G27060	Length:	958	Species:	Arabidopsis thaliana

Alignment Length:	920	Identity:	215/920 - (23%)
Similarity:	339/920 - (36%)	Gaps:	241/920 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 CSWSYNGTSSVHCALRLIERQPGLDLQGADGSSQLTIQCSEL-YLFESTLPVAVFARLQTLEAL- 139
            || |.:|....:.::|.:.....|||...|...|:|.....| :|....|....|:. |.|.::
plant   105 CS-SLHGRFHSNSSIRNLHFLTTLDLSFNDFKGQITSSIENLSHLTYLDLSSNHFSG-QILNSIG 167

  Fly   140 RLDSCKLLQLPNNAFEGLATLKSLRLS-------THNSEWGPTRTLELFPDSLGGLKQLTDLDLG 197
            .|.....|.|.:|.|.|.|......||       ::|..:|.      ||.|:|||..||.|.|.
plant   168 NLSRLTYLNLFDNQFSGQAPSSICNLSHLTFLDLSYNRFFGQ------FPSSIGGLSHLTTLSLF 226

  Fly   198 DNNLR-QLPSGFLCPVGNLQVLNLTRNR--------IRTAEQMGFADMNCGAGSGSAGSELQVLD 253
            .|... |:||. :..:.||..|:|:.|.        |....|:.|..:
plant   227 SNKFSGQIPSS-IGNLSNLTTLDLSNNNFSGQIPSFIGNLSQLTFLGL----------------- 273

  Fly   254 ASHNELRSISESWGISRLRRLQHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLE-TLPEGLFA 317
            .|:|.:..|..|:|  .|.:|..|.:..|.||......|..|..|.:::||||... |||..:.:
plant   274 FSNNFVGEIPSSFG--NLNQLTRLYVDDNKLSGNFPNVLLNLTGLSLLSLSNNKFTGTLPPNITS 336

  Fly   318 GSKELREIHLQQNELY-ELPKGLFHRLEQLLVVDLSGNQL-----------TSN----HVDNTTF 366
            .| .|.:.....|... ..|..|| .:..|..:.|:||||           .||    .:.|..|
plant   337 LS-NLMDFDASDNAFTGTFPSFLF-TIPSLTYIRLNGNQLKGTLEFGNISSPSNLYELDIGNNNF 399

  Fly   367 AG--------LIRLIVLNLAH-NALTRIDYRTFKELYFLQILNLRN-NSIGHIEDNAFLPLYNLH 421
            .|        |::|..|:::| |....:|:..|..|..|..||:.: |:...|:.|.||..:
plant   400 IGPIPSSISKLVKLFRLDISHLNTQGPVDFSIFSHLKSLLDLNISHLNTTTRIDLNYFLSYF--- 461

  Fly   422 TLNLAENRLHTLDDKLFNGLYVLSKLTLNNNLISVVEPAVFKNCSDL-KELDLSSNQLNEVPRAL 485
                  .||..||   .:|.:|.:     .|..||.:|.     |.| :.|.||...:.|.|..:
plant   462 ------KRLLLLD---LSGNHVSA-----TNKSSVSDPP-----SQLIQSLYLSGCGITEFPEFV 507

  Fly   486 QDLAMLRTLDLGENQIRTFDNQSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQ 550
            :....|..||:..|:|:                       |.:...::: ||.|..:||:.|.:.
plant   508 RTQHELGFLDISNNKIK-----------------------GQVPDWLWR-LPILYYVNLSNNTLI 548

  Fly   551 SIERGSFDKNFELEAIRLDRNFLADINGVFATLVSLLWLNLSENHLVWFD------YAFIPSNLK 609
            ..:|.|..:...|..:..:.||:..|......|.||..|:||:|:   |:      ...:.|.|.
plant   549 GFQRPSKPEPSLLYLLGSNNNFIGKIPSFICGLRSLNTLDLSDNN---FNGSIPRCMGHLKSTLS 610

  Fly   610 WLDIHGNYIEALGNYYKLQEEIRVKTLDASHNRITEIGPMSIP--NTIELLFINNNLIGNVQPNA 672
            .|::..|::.  |...|...|| :::||..||::....|.|:.  :|:|:|.:.:|.|.:..|
plant   611 VLNLRQNHLS--GGLPKQIFEI-LRSLDVGHNQLVGKLPRSLSFFSTLEVLNVESNRINDTFP-- 670

  Fly   673 FVDKANLARVDLYANQLSKLQLQQLRVAPVVAP---KPLPEFYLGGNPFECDCTMDWLQRINNLT 734
                       .:.:.|.|||:..||......|   ...||.
plant   671 -----------FWLSSLPKLQVLVLRSNAFHGPIHEATFPEL----------------------- 701

  Fly   735 TRQHPRVMDMANIECVMPHARGAAVRPLSGLRPQDFLCRYESHCFALCHCCDFDACDCEMTCPSN 799
                 |::|::       |.|      .:|..|.::..::.    |:......:....|....|.
plant   702 -----RIIDIS-------HNR------FNGTLPTEYFVKWS----AMSSLGKNEDQSNEKYMGSG 744

  Fly   800 CTCYHDQIWSTN---------------VVDCGGQQ-TTELPRRVPMDSSVVYLDGNNFPVLKNHA 848
             ..|.|.:...|               .||..|.: ..|:|:.:.:...::.|.      |.|:|
plant   745 -LYYQDSMVLMNKGVAMELVRILTIYTAVDFSGNRFEGEIPKSIGLLKELLVLS------LSNNA 802

  Fly   849 FIGRKNLRALYVNGSQVAAIQNRTFASLASLQLLHLADNKLRTLHGYEFEQLSALRELYLQNNQL 913
            |.|.                ...:..:|.:|:.|.::.|||......|...||.|..:...:|||
plant   803 FSGH----------------MPSSMGNLTALESLDVSKNKLTGEIPQELGDLSFLAYMNFSHNQL 851

  Fly   914 TTIENATLAP 923
                 |.|.|
plant   852 -----AGLVP 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	23/73 (32%)
		leucine-rich repeat	136..159	CDD:275380	7/23 (30%)
		leucine-rich repeat	160..190	CDD:275380	10/36 (28%)
		LRR_8	189..259	CDD:290566	18/78 (23%)
		leucine-rich repeat	191..214	CDD:275380	8/23 (35%)
		leucine-rich repeat	215..248	CDD:275380	7/40 (18%)
		LRR_RI	247..501	CDD:238064	75/281 (27%)
		LRR_8	247..308	CDD:290566	18/60 (30%)
		leucine-rich repeat	249..273	CDD:275380	6/23 (26%)
		leucine-rich repeat	274..297	CDD:275380	7/22 (32%)
		LRR_8	297..356	CDD:290566	18/60 (30%)
		leucine-rich repeat	298..321	CDD:275380	9/23 (39%)
		leucine-rich repeat	322..345	CDD:275380	5/23 (22%)
		LRR_8	345..406	CDD:290566	23/85 (27%)
		leucine-rich repeat	346..371	CDD:275380	12/47 (26%)
		leucine-rich repeat	372..395	CDD:275380	7/23 (30%)
		leucine-rich repeat	396..419	CDD:275380	8/23 (35%)
		LRR_8	419..478	CDD:290566	15/59 (25%)
		leucine-rich repeat	420..443	CDD:275380	5/22 (23%)
		leucine-rich repeat	444..467	CDD:275380	4/22 (18%)
		LRR_RI	466..622	CDD:238064	37/162 (23%)
		leucine-rich repeat	468..488	CDD:275380	6/20 (30%)
		LRR_8	491..549	CDD:290566	12/57 (21%)
		leucine-rich repeat	491..514	CDD:275380	5/22 (23%)
		leucine-rich repeat	515..536	CDD:275380	1/20 (5%)
		leucine-rich repeat	539..562	CDD:275380	6/22 (27%)
		leucine-rich repeat	563..585	CDD:275380	5/21 (24%)
		leucine-rich repeat	586..626	CDD:275380	11/45 (24%)
		leucine-rich repeat	627..653	CDD:275380	8/27 (30%)
		LRRCT	716..772	CDD:214507	6/55 (11%)
		LRRNT	796..830	CDD:214470	9/49 (18%)
		leucine-rich repeat	812..829	CDD:275380	5/17 (29%)
		leucine-rich repeat	833..854	CDD:275380	6/20 (30%)
		LRR_8	853..913	CDD:290566	11/59 (19%)
		leucine-rich repeat	855..878	CDD:275380	1/22 (5%)
		LRR_4	878..918	CDD:289563	12/39 (31%)
		leucine-rich repeat	879..902	CDD:275380	7/22 (32%)
		leucine-rich repeat	903..926	CDD:275380	7/21 (33%)
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
RLP53	NP_001332753.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000