DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and RLP50

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_567412.1	Gene:	RLP50 / 827026	AraportID:	AT4G13920	Length:	891	Species:	Arabidopsis thaliana

Alignment Length:	797	Identity:	182/797 - (22%)
Similarity:	274/797 - (34%)	Gaps:	272/797 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 CSW--------------------SYNGTSSVHCALRLIERQPGLDLQGADGSSQLTIQCSELYLF 121
            |||                    ..||....:.:|..::....|||...|      :.|
plant    67 CSWGGISCDPKTGVVVELDLGNSDLNGRLRSNSSLFRLQHLQSLDLSYND------LSC------ 119

  Fly   122 ESTLPVAVFARLQTLEALRLDSCKLL-QLPNNAFEGLATLKSLRLSTHNSEWGP----------T 175
              |||.: ....:.|..|.|..|.|. ::| .:...|:.|..|.||.::...|.          .
plant   120 --TLPDS-SGNFKYLRVLNLLGCNLFGEIP-TSLRSLSYLTDLDLSYNDDLTGEILDSMGNLKHL 180

  Fly   176 RTLEL--------FPDSLGGLKQLTDLDLGDNNLR-QLPSGFLCPVGN---LQVLNLTRNRIRTA 228
            |.|.|        .|.|||.|..||||||..|... :||..    :||   |:||||.|...
plant   181 RVLSLTSCKFTGKIPSSLGNLTYLTDLDLSWNYFTGELPDS----MGNLKSLRVLNLHRCNF--- 238

  Fly   229 EQMGFADMNCGAGSGSAGSELQVLDASHNELRSISESWGISRLRRLQHLNLAYNNLSELSG---- 289
                |..:....||   .|.|..||.|.||..|.... .:|.|.||....|...|||.|:.
plant   239 ----FGKIPTSLGS---LSNLTDLDISKNEFTSEGPD-SMSSLNRLTDFQLMLLNLSSLTNVDLS 295

  Fly   290 ---------EALAGLASLRIVNLSNNHLE-TLPEGLF------------------------AGSK 320
                     ..::.|:.|...::|.|... |:|..||                        :...
plant   296 SNQFKAMLPSNMSSLSKLEAFDISGNSFSGTIPSSLFMLPSLIKLDLGTNDFSGPLKIGNISSPS 360

  Fly   321 ELREIHLQQNELY-ELPK------------------------GLFHRLEQLLVVDLSG---NQLT 357
            .|:|:::.:|.:. .:|:                        .:|.:|:.|..:||||   |..:
plant   361 NLQELYIGENNINGPIPRSILKLVGLSALSLSFWDTGGIVDFSIFLQLKSLRSLDLSGINLNISS 425

  Fly   358 SNHVDNTTFAGLIRLIVLNLAHNALTRIDYRTFKE-------LYFLQILNLRNNSIGHIEDNAFL 415
            |:|:.:            ::.|..|:..:...|.:       ||.|.|      |...||.....
plant   426 SHHLPS------------HMMHLILSSCNISQFPKFLENQTSLYHLDI------SANQIEGQVPE 472

  Fly   416 PLYNLHTL---NLAEN----RLHTLDDKLFN-------------------GLYVLSKLTLNNNLI 454
            .|:.|.||   |:|:|    .|..|.:.:::                   |..|||    |||..
plant   473 WLWRLPTLRYVNIAQNAFSGELTMLPNPIYSFIASDNKFSGEIPRAVCEIGTLVLS----NNNFS 533

  Fly   455 SVVEPAVFKNCSDLKELDLSSNQLNEVPRALQDLAMLRTLDLGENQIRTFDNQSFKNLHQLTGLR 519
            ..:.|....:...|..|.|.:|.|:.|.........||:||:|.|::.....:|..|...|..|.
plant   534 GSIPPCFEISNKTLSILHLRNNSLSGVIPEESLHGYLRSLDVGSNRLSGQFPKSLINCSYLQFLN 598

  Fly   520 LIDNQIGNITVGMFQDLPRLSVLNLAKNRIQS--IERG---SFDKNFELEAIRLDRNFLADINGV 579
            :.:|:|.:......:.||.|.:|.|..|....  ...|   ||.|
plant   599 VEENRINDTFPSWLKSLPNLQLLVLRSNEFHGPIFSPGDSLSFSK-------------------- 643

  Fly   580 FATLVSLLWLNLSENHLVWFDYAFIPSN--LKW-------------------------------L 611
                  |.:.::|||..    ...:||:  :.|                               |
plant   644 ------LRFFDISENRF----SGVLPSDYFVGWSVMSSFVDIIDNTPGFTVVGDDQESFHKSVVL 698

  Fly   612 DIHGNYIEALGNYYKLQEEIRVKTLDASHNRITEIGPMSIPNTIELLFI---NNNLIGNVQPNAF 673
            .|.|..:|.:|:.:::     .||:|.|.||:....|.||....||:.:   ||...|::.| :.
plant   699 TIKGLNMELVGSGFEI-----YKTIDVSGNRLEGDIPESIGILKELIVLNMSNNAFTGHIPP-SL 757

  Fly   674 VDKANLARVDLYANQLS 690
            .:.:||..:||..|:||
plant   758 SNLSNLQSLDLSQNRLS 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	27/84 (32%)
		leucine-rich repeat	136..159	CDD:275380	7/23 (30%)
		leucine-rich repeat	160..190	CDD:275380	13/47 (28%)
		LRR_8	189..259	CDD:290566	26/73 (36%)
		leucine-rich repeat	191..214	CDD:275380	9/23 (39%)
		leucine-rich repeat	215..248	CDD:275380	9/32 (28%)
		LRR_RI	247..501	CDD:238064	78/352 (22%)
		LRR_8	247..308	CDD:290566	21/73 (29%)
		leucine-rich repeat	249..273	CDD:275380	9/23 (39%)
		leucine-rich repeat	274..297	CDD:275380	7/35 (20%)
		LRR_8	297..356	CDD:290566	19/111 (17%)
		leucine-rich repeat	298..321	CDD:275380	7/47 (15%)
		leucine-rich repeat	322..345	CDD:275380	6/47 (13%)
		LRR_8	345..406	CDD:290566	15/70 (21%)
		leucine-rich repeat	346..371	CDD:275380	8/27 (30%)
		leucine-rich repeat	372..395	CDD:275380	4/29 (14%)
		leucine-rich repeat	396..419	CDD:275380	6/22 (27%)
		LRR_8	419..478	CDD:290566	20/84 (24%)
		leucine-rich repeat	420..443	CDD:275380	9/48 (19%)
		leucine-rich repeat	444..467	CDD:275380	6/22 (27%)
		LRR_RI	466..622	CDD:238064	39/193 (20%)
		leucine-rich repeat	468..488	CDD:275380	6/19 (32%)
		LRR_8	491..549	CDD:290566	18/57 (32%)
		leucine-rich repeat	491..514	CDD:275380	8/22 (36%)
		leucine-rich repeat	515..536	CDD:275380	4/20 (20%)
		leucine-rich repeat	539..562	CDD:275380	8/27 (30%)
		leucine-rich repeat	563..585	CDD:275380	0/21 (0%)
		leucine-rich repeat	586..626	CDD:275380	12/72 (17%)
		leucine-rich repeat	627..653	CDD:275380	9/25 (36%)
		LRRCT	716..772	CDD:214507
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
RLP50	NP_567412.1	leucine-rich repeat	494..517	CDD:275380	2/22 (9%)
		leucine-rich repeat	524..546	CDD:275380	7/25 (28%)
		leucine-rich repeat	547..569	CDD:275380	6/21 (29%)
		leucine-rich repeat	570..593	CDD:275380	8/22 (36%)
		leucine-rich repeat	594..617	CDD:275380	5/22 (23%)
		leucine-rich repeat	618..643	CDD:275380	7/24 (29%)
		leucine-rich repeat	644..705	CDD:275380	10/64 (16%)
		leucine-rich repeat	707..738	CDD:275380	10/35 (29%)
		leucine-rich repeat	739..762	CDD:275380	5/23 (22%)
		leucine-rich repeat	763..786	CDD:275380	6/12 (50%)
		PLN00113	1..>823	CDD:331614	182/797 (23%)
		leucine-rich repeat	81..94	CDD:275381	1/12 (8%)
		leucine-rich repeat	107..130	CDD:275380	8/37 (22%)
		leucine-rich repeat	131..154	CDD:275380	7/23 (30%)
		leucine-rich repeat	155..179	CDD:275380	5/23 (22%)
		leucine-rich repeat	180..203	CDD:275380	8/22 (36%)
		leucine-rich repeat	204..227	CDD:275380	11/26 (42%)
		leucine-rich repeat	228..251	CDD:275380	9/32 (28%)
		leucine-rich repeat	252..288	CDD:275380	14/36 (39%)
		leucine-rich repeat	289..312	CDD:275380	2/22 (9%)
		leucine-rich repeat	313..336	CDD:275380	7/22 (32%)
		PLN00113	<355..>418	CDD:331614	9/62 (15%)
		leucine-rich repeat	362..385	CDD:275380	4/22 (18%)
		leucine-rich repeat	386..410	CDD:275380	2/23 (9%)
		leucine-rich repeat	433..455	CDD:275380	3/21 (14%)
		leucine-rich repeat	456..479	CDD:275380	9/28 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000