DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and RLP48

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_193124.2	Gene:	RLP48 / 827022	AraportID:	AT4G13880	Length:	725	Species:	Arabidopsis thaliana

Alignment Length:	666	Identity:	154/666 - (23%)
Similarity:	257/666 - (38%)	Gaps:	175/666 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 CSWSYNGTSSVHC---ALRLIERQPGLDLQGADGSSQLTIQCSELYLFESTLPVAVFARLQTLEA 138
            |||     :.|.|   ..:::|    |||..:..:..|....|   ||          |||.|::
plant    74 CSW-----NRVSCDPKTGKVVE----LDLMSSCLNGPLRSNSS---LF----------RLQHLQS 116

  Fly   139 LRLDSCKLLQLPNNAFEGLATLKSLRLSTHNSEWGPTRTLELF---PDSLGGLKQLTDLDLGDNN 200
            |.|.|..:..:..::...|..|:||..          ||..||   |.|||.|..||.|||..|:
plant   117 LELSSNNISGILPDSIGNLKYLRSLSF----------RTCHLFGKIPSSLGSLSYLTHLDLSYND 171

  Fly   201 LRQ--LPSGFLCPVGNLQVLNLTRNRIRTAEQMGFADMNCGAGSGSAGSELQV---------LDA 254
            ...  ..||     |||..|...:..:.....:.:.|:......|....:..:         ||.
plant   172 FTSEGPDSG-----GNLNRLTDLQLVLLNLSSVTWIDLGSNQLKGRGIVDFSIFLHLKSLCSLDL 231

  Fly   255 SHNELRSISESWGISRLRRLQHLNLAYNNL---SELSGEALAG---LASLRIV------------ 301
            |:...||:.:....|.|..|..|:|:..||   |.||..:..|   |||..||
plant   232 SYLNTRSMVDLSFFSHLMSLDELDLSGINLKISSTLSFPSATGTLILASCNIVEFPKFLENQTSL 296

  Fly   302 ---NLSNNHLE-TLPEGLFAGSKELREIHLQQN----ELYELPKGLFHRLEQLLVVDLSGNQLTS 358
               ::|.||:| .:||.|:. ...|..:::.||    ||..||..::..:       .|.||. |
plant   297 FYLDISANHIEGQVPEWLWR-LPTLSFVNIAQNSFSGELPMLPNSIYSFI-------ASDNQF-S 352

  Fly   359 NHVDNTTFAGLIRLIVLNLAHNALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTL 423
            ..:..|. ..|:.|..|.|::|..:....|.|:....:.||:|||||:..:.....:.
plant   353 GEIPRTV-CELVSLNTLVLSNNKFSGSIPRCFENFKTISILHLRNNSLSGVFPKEIIS------- 409

  Fly   424 NLAENRLHTLDDKLFNGLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNE-VPRALQD 487
                              ..|:.|.:.:|.:|...|.....|:||:.|::..|::|: .|..|:.
plant   410 ------------------ETLTSLDVGHNWLSGQLPKSLIKCTDLEFLNVEDNRINDKFPFWLRS 456

  Fly   488 LAMLRTLDLGENQ-----IRTFDNQSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKN 547
            |:.|:.|.|..|:     ....|:.||                           |:|.:.::::|
plant   457 LSNLQILVLRSNEFYGPIFSLEDSLSF---------------------------PKLRIFDISEN 494

  Fly   548 RIQSIERGSFDKNFELEAIRLDRNFLADINGVFATLVSLLWLNLSENHLVWFDYAFIPSNLKWLD 612
            ....:....:...:         :.::.:..:|.|...:..|.:.:.   ::..:.:.:|
plant   495 HFTGVLPSDYFAGW---------SAMSSVVDIFDTTPQVHILGVFQG---YYHNSVVLTN----- 542

  Fly   613 IHGNYIEALGNYYKLQEEIRVKTLDASHNRITEIGPMSIPNTIELLFI---NNNLIGNVQPNAFV 674
             .|..:|.:|:.:.:     .||:|.|.||:....|.||....||:.:   ||...|::.| :..
plant   543 -KGLNMELVGSGFTI-----YKTIDVSGNRLEGDIPESIGILKELIVLNMSNNAFTGHIPP-SLS 600

  Fly   675 DKANLARVDLYANQLS 690
            :.:||..:||..|:||
plant   601 NLSNLQSLDLSQNRLS 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	23/68 (34%)
		leucine-rich repeat	136..159	CDD:275380	5/22 (23%)
		leucine-rich repeat	160..190	CDD:275380	12/32 (38%)
		LRR_8	189..259	CDD:290566	17/80 (21%)
		leucine-rich repeat	191..214	CDD:275380	8/24 (33%)
		leucine-rich repeat	215..248	CDD:275380	4/32 (13%)
		LRR_RI	247..501	CDD:238064	72/294 (24%)
		LRR_8	247..308	CDD:290566	23/90 (26%)
		leucine-rich repeat	249..273	CDD:275380	7/32 (22%)
		leucine-rich repeat	274..297	CDD:275380	10/28 (36%)
		LRR_8	297..356	CDD:290566	19/78 (24%)
		leucine-rich repeat	298..321	CDD:275380	9/38 (24%)
		leucine-rich repeat	322..345	CDD:275380	7/26 (27%)
		LRR_8	345..406	CDD:290566	18/60 (30%)
		leucine-rich repeat	346..371	CDD:275380	6/24 (25%)
		leucine-rich repeat	372..395	CDD:275380	6/22 (27%)
		leucine-rich repeat	396..419	CDD:275380	7/22 (32%)
		LRR_8	419..478	CDD:290566	10/58 (17%)
		leucine-rich repeat	420..443	CDD:275380	0/22 (0%)
		leucine-rich repeat	444..467	CDD:275380	6/22 (27%)
		LRR_RI	466..622	CDD:238064	24/161 (15%)
		leucine-rich repeat	468..488	CDD:275380	6/20 (30%)
		LRR_8	491..549	CDD:290566	10/62 (16%)
		leucine-rich repeat	491..514	CDD:275380	7/27 (26%)
		leucine-rich repeat	515..536	CDD:275380	0/20 (0%)
		leucine-rich repeat	539..562	CDD:275380	2/22 (9%)
		leucine-rich repeat	563..585	CDD:275380	2/21 (10%)
		leucine-rich repeat	586..626	CDD:275380	5/39 (13%)
		leucine-rich repeat	627..653	CDD:275380	9/25 (36%)
		LRRCT	716..772	CDD:214507
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
RLP48	NP_193124.2	LRRNT_2	35..82	CDD:285463	4/12 (33%)
		LRR_RI	108..334	CDD:238064	67/251 (27%)
		leucine-rich repeat	114..137	CDD:275380	5/22 (23%)
		leucine-rich repeat	138..161	CDD:275380	12/32 (38%)
		leucine-rich repeat	162..185	CDD:275380	11/27 (41%)
		leucine-rich repeat	199..225	CDD:275380	2/25 (8%)
		LRR	214..>503	CDD:227223	78/350 (22%)
		leucine-rich repeat	226..250	CDD:275380	7/23 (30%)
		leucine-rich repeat	251..272	CDD:275380	8/20 (40%)
		leucine-rich repeat	273..295	CDD:275380	6/21 (29%)
		leucine-rich repeat	296..317	CDD:275380	7/21 (33%)
		leucine-rich repeat	320..364	CDD:275380	13/52 (25%)
		LRR_RI	347..>470	CDD:238064	37/149 (25%)
		leucine-rich repeat	365..388	CDD:275380	6/22 (27%)
		leucine-rich repeat	389..415	CDD:275380	8/50 (16%)
		leucine-rich repeat	416..435	CDD:275380	4/18 (22%)
		leucine-rich repeat	436..459	CDD:275380	7/22 (32%)
		leucine-rich repeat	460..485	CDD:275380	7/51 (14%)
		leucine-rich repeat	486..542	CDD:275380	5/67 (7%)
		leucine-rich repeat	549..580	CDD:275380	10/35 (29%)
		LRR_8	558..615	CDD:290566	20/57 (35%)
		leucine-rich repeat	581..604	CDD:275380	5/23 (22%)
		leucine-rich repeat	605..628	CDD:275380	6/12 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000